-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
 MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen
 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 TJZlRRA59h+isNEyx7bOiZv6C/ExLMEQNbUl27ttni12fB4/QxfcGOp3z+PWYDTD
 0/0r7i63wcSzLWF8sZJn8w==

<SEC-DOCUMENT>0001276933-04-000001.txt : 20040623
<SEC-HEADER>0001276933-04-000001.hdr.sgml : 20040623
<ACCEPTANCE-DATETIME>20040623162919
ACCESSION NUMBER:		0001276933-04-000001
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20040622
FILED AS OF DATE:		20040623

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			ROTH DUANE J
		CENTRAL INDEX KEY:			0001276933

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-12950
		FILM NUMBER:		04877597

	BUSINESS ADDRESS:	
		STREET 1:		ALLIANCE PHARMACEUTICAL CORP
		STREET 2:		6175 LUSK BLVD
		CITY:			SAN DIEGO
		STATE:			CA
		ZIP:			921221
		BUSINESS PHONE:		8584105326

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			ALLIANCE PHARMACEUTICAL CORP
		CENTRAL INDEX KEY:			0000736994
		STANDARD INDUSTRIAL CLASSIFICATION:	IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES [2835]
		IRS NUMBER:				141644018
		STATE OF INCORPORATION:			NY
		FISCAL YEAR END:			0630

	BUSINESS ADDRESS:	
		STREET 1:		6175 LUSK BLVD
		CITY:			SAN DIEGO
		STATE:			CA
		ZIP:			92121
		BUSINESS PHONE:		8584105200

	MAIL ADDRESS:	
		STREET 1:		617 LUSK BLVD
		CITY:			SAN DIEGO
		STATE:			CA
		ZIP:			92121

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	OTISVILLE BIOPHARM INC
		DATE OF NAME CHANGE:	19890310

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	OTISVILLE BIOTECH INC
		DATE OF NAME CHANGE:	19861216
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>primary_doc.xml
<DESCRIPTION>PRIMARY DOCUMENT
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2004-06-22</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0000736994</issuerCik>
        <issuerName>ALLIANCE PHARMACEUTICAL CORP</issuerName>
        <issuerTradingSymbol>ALLP.OB</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001276933</rptOwnerCik>
            <rptOwnerName>ROTH DUANE J</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1></rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity></rptOwnerCity>
            <rptOwnerState></rptOwnerState>
            <rptOwnerZipCode></rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>CHAIRMAN AND CEO</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <derivativeTable>
        <derivativeTransaction>
            <securityTitle>
                <value>NON-QUALIFIED STOCK OPTION</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>0.41</value>
            </conversionOrExercisePrice>
            <transactionDate>
                <value>2004-06-22</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>5</transactionFormType>
                <transactionCode>A</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionTimeliness>
                <value>E</value>
            </transactionTimeliness>
            <transactionAmounts>
                <transactionShares>
                    <value>180000</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0.41</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <exerciseDate>
                <value>2004-06-22</value>
            </exerciseDate>
            <expirationDate>
                <value>2014-06-22</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>COMMON STOCK</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>180000</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>180000</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeTransaction>
    </derivativeTable>

    <ownerSignature>
        <signatureName>DUANE J ROTH</signatureName>
        <signatureDate>2004-06-23</signatureDate>
    </ownerSignature>
</ownershipDocument>

</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----