EXHIBIT 32.2


                    CERTIFICATION OF CHIEF FINANCIAL OFFICER
            PURSUANT TO SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

         Solely for the purpose of complying with 18 U.S.C. ss. 1350, as adopted
pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, I, the undersigned
Chief Financial Officer of Alliance Pharmaceutical Corp. (the "Company"), hereby
certify, based on my knowledge, that the Quarterly Report on Form 10-Q of the
Company for the six months ended December 31, 2008 (the "Report") fully complies
with the requirements of Section 13(a) or 15(d) of the Securities and Exchange
Act of 1934 and that information contained in the Report fairly presents, in all
material respects, the financial condition and results of operations of the
Company.

Date:  February 16, 2009





By:   /s/ JACK DEFRANCO
      --------------------------
          Jack DeFranco
          Chief Financial Officer