EXHIBIT 32.1

                    CERTIFICATION OF CHIEF EXECUTIVE OFFICER
            PURSUANT TO SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

         Solely for the purpose of complying with 18 U.S.C. ss. 1350, as adopted
pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, I, the undersigned
Chief Executive Officer of Alliance Pharmaceutical Corp. (the "Company"), hereby
certify, based on my knowledge, that the Quarterly Report on Form 10-Q of the
Company for the three months ended September 30, 2008 (the "Report") fully
complies with the requirements of Section 13(a) or 15(d) of the Securities and
Exchange Act of 1934 and that information contained in the Report fairly
presents, in all material respects, the financial condition and results of
operations of the Company.

Date:  November 14, 2008





BY: /s/ Duane J. Roth
    ---------------------
         Duane J. Roth
         Chief Executive Officer