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GENZYME CORPORATION AND SUBSIDIARIES FORM 10-Q, MARCH 31, 2003 TABLE OF CONTENTS

UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

FORM 10-Q

ý	QUARTERLY REPORT UNDER SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
For the quarterly period ended March 31, 2003
or
o	TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934
For the transition period from to

Commission file number 0-14680

GENZYME CORPORATION
(Exact name of registrant as specified in its charter)

Massachusetts (State or other jurisdiction of incorporation or organization)		06-1047163 (I.R.S. Employer Identification No.)
One Kendall Square, Cambridge, Massachusetts (Address of principal executive offices)		02139 (zip code)
(617) 252-7500 (Registrant's telephone number, including area code)

Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days. Yes ý No o

Indicate by check mark whether the Registrant is an accelerated filer (as defined by Rule 12b-2 of the Exchange Act). Yes ý No o

The number of shares outstanding of each of the issuer's series of common stock as of April 30, 2003:

Genzyme General Division Common Stock		215,788,807
Genzyme Biosurgery Division Common Stock		40,686,433
Genzyme Molecular Oncology Division Common Stock		16,982,963

NOTE REGARDING FORWARD-LOOKING STATEMENTS

This Form 10-Q contains forward-looking statements, including statements regarding our:

•: projected timetables for the preclinical and clinical development of, regulatory submissions and approvals for, and market introduction of, our products and services;
•: the entry into new collaborations and licensing agreements;
•: estimates of the potential markets for our products and services, including the anticipated drivers for future growth;
•: sales and marketing plans;
•: assessments of competitors and potential competitors and the anticipated impact of potentially competitive products on our revenues;
•: estimates of the capacity of, and the projected timetable of approvals for, manufacturing and other facilities to support our products and services;
•: expected future revenues, operations and expenditures;
•: allocations of revenue, expenses, liabilities and income tax benefits;
•: maintenance of financial covenants contained in our revolving credit facility and our intention to refinance this facility in 2003;
•: assessment of the outcome of litigation and other governmental proceedings;
•: expectations concerning future dividends and stock option awards; and
•: projected cash needs.

These statements are subject to risks and uncertainties, and our actual results may differ significantly from those that are described in this report. These risks and uncertainties include:

•: our ability to successfully complete preclinical and clinical development of our products and services;
•: our ability to manufacture sufficient amounts of our products for development and commercialization activities and to do so in a timely and cost-effective manner;
•: our ability to obtain and maintain adequate patent and other proprietary rights protection of our products and services and successfully enforce our proprietary rights;
•: the scope, validity and enforceability of patents and other proprietary rights held by third parties and their impact on our ability to commercialize our products and services;
•: the accuracy of our estimates of the size and characteristics of the markets to be addressed by our products and services, including growth projections;
•: market acceptance of our products and services;
•: our ability to identify new patients for our products and services;
•: our ability to identify new collaborators and licensees and to negotiate mutually satisfactory agreements with them;
•: the accuracy of our information regarding the products and resources of our competitors and potential competitors;
•: the content and timing of submissions to and decisions made by the Food and Drug Administration, commonly referred to as the FDA, and other regulatory agencies;

•: decisions made by the U.S. Federal Trade Commission, commonly referred to as the FTC, the United States District Court, the United Kingdom Competition Appeal Tribunal and other judicial bodies;
•: approval of the manufacturing facilities for Fabrazyme® and Aldurazyme® enzymes and Renagel® phosphate binder;
•: the availability of reimbursement for our products and services from third-party payors, and the extent of such coverage;
•: our ability to expand manufacturing capacity for Renagel phosphate binder and Myozyme™ enzyme;
•: our ability to optimize dosing and improve patient compliance with Renagel phosphate binder;
•: our ability to effectively manage wholesaler inventories of Renagel phosphate binder and the levels of compliance with our inventory management programs;
•: our ability to establish and maintain strategic license, collaboration and distribution arrangements;
•: the continued funding and operation of our joint ventures by our partners;
•: our ability to successfully increase market penetration for Synvisc® viscosupplementation product as a treatment for osteoarthritis of the knee and to expand its use in other joints;
•: our ability to increase market penetration in Europe for our Fabrazyme enzyme, Thyrogen® hormone and Renagel phosphate binder;
•: decisions made by our board of directors with respect to dividends, stock option awards and other matters under our charter and management and accounting policies; and
•: the possible disruption of our operations due to terrorist activities and armed conflict, including as a result of the disruption of operations of regulatory authorities, our subsidiaries, our manufacturing facilities and our customers, suppliers, distributors, couriers, collaborative partners, licensees and clinical trial sites.

We have included more detailed descriptions of these risks and uncertainties in Exhibit 99.2, "Factors Affecting Future Operating Results," to our Annual Report on Form 10-K for the fiscal year ended December 31, 2002. We encourage you to read those descriptions carefully. We caution investors not to place undue reliance on the forward-looking statements contained in this report. These statements, like all statements in this report, speak only as of the date of this report (unless another date is indicated) and we undertake no obligation to update or revise the statements. Holders of Genzyme General Stock, Biosurgery Stock and Molecular Oncology Stock are stockholders of Genzyme Corporation and are subject to all of the risks and uncertainties of Genzyme Corporation described in Exhibit 99.2 to our 2002 Form 10-K.

NOTE REGARDING REFERENCES TO GENZYME DIVISIONS AND SERIES OF STOCK

Throughout this Form 10-Q, the words "we," "us," "our" and "Genzyme" refer to Genzyme Corporation and all of its operating divisions taken as a whole, and "our board of directors" refers to the board of directors of Genzyme Corporation. In addition, we refer to our three operating divisions as follows:

•: Genzyme General Division = "Genzyme General;"
•: Genzyme Biosurgery Division = "Genzyme Biosurgery;" and
•: Genzyme Molecular Oncology Division = "Genzyme Molecular Oncology."

We currently have three designated series of common stock. Each of these series is intended to reflect the value and track the performance of one of our divisions. We refer to each series of common stock as follows:

•: Genzyme General Division Common Stock = "Genzyme General Stock;"
•: Genzyme Biosurgery Division Common Stock = "Biosurgery Stock;" and
•: Genzyme Molecular Oncology Division Common Stock = "Molecular Oncology Stock."

NOTE REGARDING INCORPORATION BY REFERENCE

The Securities and Exchange Commission allows us to disclose important information to you by referring you to other documents we have filed with the SEC. The information that we refer you to is "incorporated by reference" into this Form 10-Q. Please read that information.

NOTE REGARDING TRADEMARKS

Genzyme®, Cerezyme®, Fabrazyme®, Thyrogen®, Renagel®, Seprafilm®, Carticel®, Epicel®, Synvisc®, Hylaform® and Snowden-Pencer® are registered trademarks of Genzyme. Myozyme™, SAGE™ and Sepra™ are trademarks of Genzyme. Focal® and FocalSeal® are registered trademarks of Focal, Inc. Aldurazyme® is a registered trademark of BioMarin/Genzyme LLC. WelChol® is a registered trademark of Sankyo Pharma, Inc. NeuroCell™ is a trademark of Diacrin, Inc. Zavesca® is a registered trademark of Oxford GlycoSciences plc. All rights reserved.

GENZYME CORPORATION AND SUBSIDIARIES
FORM 10-Q, MARCH 31, 2003
TABLE OF CONTENTS


PART I.		FINANCIAL INFORMATION
ITEM 1.		Financial Statements
GENZYME CORPORATION AND SUBSIDIARIES
	Unaudited, Consolidated Statements of Operations for the Three Months Ended March 31, 2003 and 2002
	Unaudited, Consolidated Balance Sheets as of March 31, 2003 and December 31, 2002
	Unaudited, Consolidated Statements of Cash Flows for the Three Months Ended March 31, 2003 and 2002
	Notes to Unaudited, Consolidated Financial Statements
GENZYME GENERAL
	Unaudited, Combined Statements of Operations for the Three Months Ended March 31, 2003 and 2002
	Unaudited, Combined Balance Sheets as of March 31, 2003 and December 31, 2002
	Unaudited, Combined Statements of Cash Flows for the Three Months Ended March 31, 2003 and 2002
	Notes to Unaudited, Combined Financial Statements
GENZYME BIOSURGERY
	Unaudited, Combined Statements of Operations for the Three Months Ended March 31, 2003 and 2002
	Unaudited, Combined Balance Sheets as of March 31, 2003 and December 31, 2002
	Unaudited, Combined Statements of Cash Flows for the Three Months Ended March 31, 2003 and 2002
	Notes to Unaudited, Combined Financial Statements
GENZYME MOLECULAR ONCOLOGY
	Unaudited, Combined Statements of Operations for the Three Months Ended March 31, 2003 and 2002
	Unaudited, Combined Balance Sheets as of March 31, 2003 and December 31, 2002
	Unaudited, Combined Statements of Cash Flows for the Three Months Ended March 31, 2003 and 2002
	Notes to Unaudited, Combined Financial Statements
ITEM 2.		Management's Discussion and Analysis of Financial Condition and Results of Operations
ITEM 3.		Quantitative and Qualitative Disclosures About Market Risk
ITEM 4.		Controls and Procedures
PART II.		OTHER INFORMATION
ITEM 2.		Changes in Securities
ITEM 6.		Exhibits and Reports on Form 8-K
Signatures

PART 1. Financial Information

ITEM 1. Financial Statements

GENZYME CORPORATION AND SUBSIDIARIES

Consolidated Statements of Operations

(Unaudited, amounts in thousands)

				Three Months Ended March 31,
				2003			2002
Revenues:
	Net product sales			$	346,489		$	266,626
	Net service sales				31,498			26,683
	Revenues from research and development contracts:
		Related parties			438			612
		Other			3,434			4,019

			Total revenues		381,859			297,940

Operating costs and expenses:
	Cost of products sold				94,834			72,154
	Cost of services sold				16,978			15,018
	Selling, general and administrative				114,224			102,958
	Research and development (including research and development related to contracts)				75,631			82,141
	Amortization of intangibles				17,505			17,597

			Total operating costs and expenses		319,172			289,868

Operating income					62,687			8,072

Other income (expenses):
	Equity in net loss of unconsolidated affiliates				(4,194	)		(4,094	)
	Gain on investments in equity securities				—			166
	Other				750			(864	)
	Investment income				11,614			13,437
	Interest expense				(6,490	)		(6,806	)

			Total other income		1,680			1,839

Income before income taxes					64,367			9,911
Provision for income taxes					(18,998	)		(3,138	)

Net income before cumulative effect of change in accounting for goodwill					45,369			6,773
Cumulative effect of change in accounting for goodwill					—			(98,270	)

Net income (loss)				$	45,369		$	(91,497	)

Comprehensive income (loss), net of tax:
	Net income (loss)			$	45,369		$	(91,497	)

	Other comprehensive income (loss), net of tax:
		Foreign currency translation adjustments			14,774			(9,200	)
		Gain on affiliate sale of stock, net of tax			2,856			—
		Unrealized gains (losses) on securities, net of tax			3,999			(23,957	)
		Other			69			378

	Other comprehensive income (loss)				21,698			(32,779	)

Comprehensive income (loss)				$	67,067		$	(124,276	)

The accompanying notes are an integral part of these unaudited, consolidated financial statements.

			Three Months Ended March 31,
			2003			2002
Net income (loss) per share:
Allocated to Genzyme General Stock:
	Genzyme General division net income		$	57,793		$	24,309
	Tax benefit allocated from Genzyme Biosurgery			2,322			4,299
	Tax benefit allocated from Genzyme Molecular Oncology			1,763			2,130

	Net income allocated to Genzyme General Stock		$	61,878		$	30,738

	Net income per share of Genzyme General Stock:
		Basic	$	0.29		$	0.14

		Diluted	$	0.28		$	0.14

	Weighted average shares outstanding:
		Basic		215,091			213,332

		Diluted		220,432			221,064

Allocated to Biosurgery Stock:
	Genzyme Biosurgery net loss before cumulative effect of change in accounting for goodwill		$	(14,102	)	$	(20,382	)
	Cumulative effect of change in accounting for goodwill			—			(98,270	)

	Genzyme Biosurgery division net loss			(14,102	)		(118,652	)
	Allocated tax benefit			2,408			2,448

	Net loss allocated to Biosurgery Stock		$	(11,694	)	$	(116,204	)

	Net loss per share of Biosurgery Stock—basic and diluted:
		Net loss per share before cumulative effect of change in accounting for goodwill	$	(0.29	)	$	(0.46	)
		Per share cumulative effect of change in accounting for goodwill		—			(2.48	)

	Net loss per share of Biosurgery Stock—basic and diluted		$	(0.29	)	$	(2.94	)

	Weighted average shares outstanding			40,578			39,564

Allocated to Molecular Oncology Stock:
	Net loss		$	(4,815	)	$	(6,031	)

	Net loss per share of Molecular Oncology Stock—basic and diluted		$	(0.28	)	$	(0.36	)

	Weighted average shares outstanding			16,939			16,763

The accompanying notes are an integral part of these unaudited, consolidated financial statements.

GENZYME CORPORATION AND SUBSIDIARIES

Consolidated Balance Sheets

(Unaudited, amounts in thousands, except par value amounts)

			March 31, 2003			December 31, 2002
ASSETS
Current assets:
	Cash and cash equivalents		$	400,302		$	406,811
	Short-term investments			114,889			105,992
	Accounts receivable, net			310,035			287,141
	Inventories			226,478			238,809
	Prepaid expenses and other current assets			45,982			45,187
	Deferred tax assets			106,167			105,094

		Total current assets		1,203,853			1,189,034
Property, plant and equipment, net				831,040			802,448
Long-term investments				719,127			682,201
Notes receivable—related parties				12,021			11,918
Goodwill, net				592,089			592,075
Other intangible assets, net				716,960			734,478
Investments in equity securities				54,496			42,945
Other noncurrent assets				34,655			27,950

		Total assets	$	4,164,241		$	4,083,049

LIABILITIES AND STOCKHOLDERS' EQUITY
Current liabilities:
	Accounts payable		$	41,933		$	44,458
	Accrued expenses			175,908			190,754
	Income taxes payable			78,203			61,964
	Deferred revenue			20,746			15,887
	Current portion of long-term debt, convertible note and capital lease obligations			294,549			294,737

		Total current liabilities		611,339			607,800
Long-term debt and capital lease obligations				25,026			25,038
Convertible debentures				575,000			575,000
Deferred revenue—noncurrent				3,611			1,771
Deferred tax liabilities				156,242			159,747
Other noncurrent liabilities				16,099			15,846

		Total liabilities		1,387,317			1,385,202

Commitments and contingencies (Note 10)
Stockholders' equity:
	Preferred stock, $0.01 par value			—			—
	Common stock:
		Genzyme General Stock, $0.01 par value		2,155			2,148
		Biosurgery Stock, $0.01 par value		406			405
		Molecular Oncology Stock, $0.01 par value		169			169
	Additional paid-in capital—Genzyme General Stock			1,822,608			1,810,963
	Additional paid-in capital—Biosurgery Stock			823,566			823,364
	Additional paid-in capital—Molecular Oncology Stock			148,864			148,799
	Deferred compensation			(364	)		(605	)
	Notes receivable from stockholders			(12,857	)		(12,706	)
	Accumulated deficit			(85,599	)		(130,968	)
	Accumulated other comprehensive income			77,976			56,278

		Total stockholders' equity		2,776,924			2,697,847

		Total liabilities and stockholders' equity	$	4,164,241		$	4,083,049

The accompanying notes are an integral part of these unaudited, consolidated financial statements.

GENZYME CORPORATION AND SUBSIDIARIES

Consolidated Statements of Cash Flows

(Unaudited, amounts in thousands)

					Three Months Ended March 31,
					2003			2002
Cash Flows from Operating Activities:
	Net income (loss)				$	45,369		$	(91,497	)
	Reconciliation of net income (loss) to net cash provided by operating activities:
		Depreciation and amortization				35,614			31,547
		Non-cash compensation expense				242			392
		Provision for bad debts				1,119			2,163
		Equity in net loss of unconsolidated affiliates				4,194			4,094
		Gain on investments in equity securities				—			(166	)
		Deferred income tax benefit				(4,964	)		(3,802	)
		Other				618			1,820
		Cumulative effect of change in accounting for goodwill				—			98,270
		Increase (decrease) in cash from working capital changes:
			Accounts receivable			(21,057	)		3,695
			Inventories			13,353			(3,659	)
			Prepaid expenses and other current assets			(504	)		(7,621	)
			Accounts payable, accrued expenses and deferred revenue			(13,980	)		(18,481	)
			Income taxes payable and tax benefits from stock options			16,386			5,961

				Cash flows from operating activities		76,390			22,716

Cash Flows from Investing Activities:
	Purchases of investments					(167,469	)		(118,015	)
	Sales and maturities of investments					119,850			172,878
	Purchases of equity securities					(1,400	)		(1,610	)
	Purchases of property, plant and equipment					(45,752	)		(43,541	)
	Investments in unconsolidated affiliates					(4,112	)		(8,151	)
	Other					(602	)		2,697

				Cash flows from investing activities		(99,485	)		4,258

Cash Flows from Financing Activities:
	Proceeds from issuance of common stock					9,011			11,736
	Proceeds from draw on credit facility					—			35,000
	Payments of debt and capital lease obligations					(202	)		(693	)
	Bank overdraft					2,289			(2,000	)
	Payments of notes receivable from stockholders					—			136
	Other					249			(714	)

				Cash flows from financing activities		11,347			43,465

Effect of exchange rate changes on cash						5,239			(1,916	)

Increase (decrease) in cash and cash equivalents						(6,509	)		68,523
Cash and cash equivalents at beginning of period						406,811			247,011

Cash and cash equivalents at end of period					$	400,302		$	315,534

The accompanying notes are an integral part of these unaudited, consolidated financial statements.

GENZYME CORPORATION AND SUBSIDIARIES

Notes To Unaudited, Consolidated Financial Statements

1. Description of Business

We are a biotechnology and human healthcare company that develops innovative products and provides services for significant unmet medical needs. We have three operating divisions:

•

Genzyme General, which develops and markets:

•: therapeutic products, with an expanding focus on products to treat patients suffering from genetic diseases and other chronic debilitating diseases, including a family of diseases known as lysosomal storage disorders, or LSDs, and other specialty therapeutics;
•: renal products, with a focus on products that treat patients suffering from renal diseases, including chronic renal failure;
•: diagnostic products, with a focus on in vitro diagnostics; and
•: other products and services, such as genetic testing services and pharmaceutical drug materials.

•

Genzyme Biosurgery, which develops and markets biotherapeutic and biomaterial products, with an emphasis on products that meet medical needs in the orthopaedics, cardiovascular and broader surgical areas; and

•

Genzyme Molecular Oncology, which is developing a new generation of cancer products focused on cancer vaccines and angiogenesis inhibitors through the integration of its genomics, gene and cell therapy, small molecule drug discovery and protein therapeutic capabilities.

2. Basis of Presentation and Significant Accounting Policies

Basis of Presentation

Our unaudited, consolidated financial statements for each period include the statements of operations, balance sheets and statements of cash flows of each of our divisions, and for our corporate operations taken as a whole. We eliminate all significant intracompany items and transactions in consolidation. We prepared our unaudited, consolidated financial statements following the requirements of the SEC for interim reporting. As permitted under these rules, we condense or omit certain footnotes and other financial information that are normally required by accounting principles generally accepted in the U.S. We have reclassified certain 2002 data to conform to our 2003 presentation.

These financial statements include all normal and recurring adjustments that we consider necessary for the fair presentation of our financial position and operating results. Since these are interim financial statements, you should also read our consolidated financial statements and notes included in our 2002 Form 10-K. Revenues, expenses, assets and liabilities can vary from quarter to quarter. Therefore, the results and trends in these interim financial statements may not be indicative of results for future periods.

Net Income (Loss) Per Share

We calculate earnings per share for each series of stock using the two-class method. To calculate basic earnings per share for each series of stock, we divide the earnings allocated to each series of stock by the weighted average number of outstanding shares of that series of stock during the applicable period. When we calculate diluted earnings per share, we also include in the denominator all potentially dilutive securities outstanding during the applicable period. We allocate our earnings to each

series of our common stock based on the earnings attributable to that series of stock. The earnings attributable to Genzyme General Stock, as defined in our charter, is equal to the net income or loss of Genzyme General determined in accordance with accounting principles generally accepted in the U.S., and as adjusted for tax benefits allocated to or from Genzyme General in accordance with our management and accounting policies. Earnings attributable to Biosurgery Stock and Molecular Oncology Stock are defined similarly and, as such, are based on the net income or loss of the corresponding division as adjusted for the allocation of tax benefits.

We calculate the income tax provision of each division as if such division were a separate taxpayer, which includes assessing realizability of deferred tax assets at the division level. Our management and accounting policies provide that if, as of the end of any fiscal quarter, a division cannot use any projected annual tax benefit attributable to it to offset or reduce its current or deferred income tax expense, we may allocate the tax benefit to other divisions in proportion to their taxable income without compensating payment or allocation to the division generating the benefit. The tax benefits allocated to Genzyme General, which are included in earnings attributable to Genzyme General Stock, were (amounts in thousands):

			Three Months Ended March 31,
			2003		2002
Tax benefits allocated from:
	Genzyme Biosurgery		$	2,322	$	4,299
	Genzyme Molecular Oncology			1,763		2,130

		Total	$	4,085	$	6,429

In future periods, Genzyme Biosurgery and Genzyme Molecular Oncology may recognize deferred tax assets in the calculation of their respective tax provisions determined on a separate division basis in accordance with accounting principles generally accepted in the U.S. However, to the extent the benefit of those deferred tax assets has been previously allocated to Genzyme General in accordance with our management and accounting policies, the benefit will be reflected as a reduction of net income in determining net income (loss) attributable to Biosurgery Stock or Molecular Oncology Stock. As of March 31, 2003, the total tax benefits previously allocated to Genzyme General from Genzyme Biosurgery and Genzyme Molecular Oncology were (amounts in thousands):

Genzyme Biosurgery		$	214,142
Genzyme Molecular Oncology			47,478

Accounting for Stock-Based Compensation

In accounting for stock-based compensation, we do not recognize compensation expense for options granted under the provisions of our stock-based compensation plans with fixed terms and an exercise price greater than or equal to the fair market value of the underlying series of our common stock on the date of grant. All stock-based awards to non-employees are accounted for at their fair value in accordance with Statement of Financial Accounting Standards, or SFAS, No. 123, as amended, and Emerging Issues Task Force, or EITF, Issue No. 96-18, "Accounting for Equity Instruments that are Issued to Other than Employees for Acquiring, or in Conjunction with Selling, Goods or Services."

In accordance with the disclosure requirements of SFAS No. 148, the following table sets forth our net income (loss) data as if compensation expense for our stock-based compensation plans was determined in accordance with SFAS No. 123, as amended, based on the fair value at the grant dates of the awards. The resulting compensation expense would be allocated to each division in accordance with our allocation policies (amounts in thousands, except per share amounts):

			Three Months Ended March 31,
			2003			2002
Net income (loss):
	As reported		$	45,369		$	(91,497	)
	Add: stock-based compensation included in as reported, net of tax			153			247
	Deduct: pro forma stock-based compensation expense, net of tax			(13,384	)		(17,432	)

	Pro forma		$	32,138		$	(108,682	)

Net income per share allocated to Genzyme General Stock:
	Basic:
		As reported	$	0.29		$	0.14
		Add: stock-based compensation, net of tax, included in net income per share allocated to Genzyme General Stock—as reported		0.00			0.00
		Deduct: pro forma stock-based compensation expense per share, net of tax		(0.05	)		(0.06	)

		Pro forma	$	0.24		$	0.08

	Diluted:
		As reported	$	0.28		$	0.14
		Add: stock-based compensation, net of tax, included in net income per share allocated to Genzyme General Stock—as reported		0.00			0.00
		Deduct: pro forma stock-based compensation expense per share, net of tax		(0.05	)		(0.07	)

		Pro forma	$	0.23		$	0.07

Net loss per share allocated to Biosurgery Stock—basic and diluted:
	As reported		$	(0.29	)	$	(2.94	)
	Deduct: pro forma stock-based compensation expense per share, net of tax			(0.03	)		(0.04	)

	Pro forma		$	(0.32	)	$	(2.98	)

Net loss per share allocated to Molecular Oncology Stock—basic and diluted:
	As reported		$	(0.28	)	$	(0.36	)
	Deduct: pro forma stock-based compensation expense per share, net of tax			(0.05	)		(0.05	)

	Pro forma		$	(0.33	)	$	(0.41	)

The effects of applying SFAS No. 123 are not likely to be representative of the effects on reported net income (loss) in future years. Additional awards in future years are anticipated.

New Accounting Pronouncements

In November 2002, the EITF published Issue No. 00-21, "Accounting for Revenue Arrangements with Multiple Deliverables," or EITF Issue No. 00-21, which addresses how to determine whether a revenue arrangement involving multiple deliverables contains more than one unit of accounting for the purposes of revenue recognition and how the revenue arrangement consideration should be measured and allocated to the separate units of accounting. EITF Issue No. 00-21 applies to all revenue arrangements that we enter into after June 30, 2003. We do not expect the adoption of EITF Issue No. 00-21 to have a material impact on our financial condition or results of operations.

In January 2003, the Financial Accounting Standards Board, or FASB, issued FASB Interpretation No., or FIN, 46, "Consolidation of Variable Interest Entities, an interpretation of Accounting Research Bulletin, or ARB, No. 51." FIN 46 requires existing unconsolidated variable interest entities to be consolidated by their primary beneficiaries if the entities do not effectively disperse risks among parties involved. Variable interest entities that effectively disperse risk will not be consolidated unless a single party holds an interest or combination of interests that effectively recombines risks that were previously dispersed. FIN 46 also requires enhanced disclosure requirements related to variable interest entities. FIN 46 applies immediately to variable interest entities created after January 31, 2003, and to variable interest entities in which an enterprise obtains an interest after that date. It applies in the first fiscal year or interim period beginning after June 15, 2003 to variable interest entities in which an enterprise holds a variable interest that it acquired before February 1, 2003.

3. Net Income (Loss) Per Share

Genzyme General Stock:

The following table sets forth our computation of basic and diluted net income per share allocated to Genzyme General Stock (amounts in thousands, except per share amounts):

				Three Months Ended March 31,
				2003		2002
Genzyme General division net income				$	57,793	$	24,309
Tax benefit allocated from Genzyme Biosurgery					2,322		4,299
Tax benefit allocated from Genzyme Molecular Oncology					1,763		2,130

Net income allocated to Genzyme General Stock—basic and diluted				$	61,878	$	30,738

Shares used in computing net income per common share—basic					215,091		213,332
	Effect of dilutive securities:
		Stock options (1)			5,332		7,712
		Warrants and stock purchase rights			9		20

			Dilutive potential common shares (2)		5,341		7,732

Shares used in computing net income per share—diluted (1,2)					220,432		221,064

Net income per share of Genzyme General Stock:
	Basic			$	0.29	$	0.14

	Diluted			$	0.28	$	0.14

(1): We did not include the securities described in the following table in the computation of Genzyme General's diluted earnings per share for each period because these securities had an exercise price greater than the average market price of Genzyme General Stock (amounts in thousands):

	Three Months Ended March 31,
	2003	2002
Shares of Genzyme General Stock issuable for options	13,739	7,096

(2): We did not include the potentially dilutive effect of the assumed conversion of the $575.0 million in principal of 3% convertible subordinated debentures allocated to Genzyme General in the computation of Genzyme General's dilutive earnings per share for the three months ended March 31, 2003 and 2002, because the conditions for conversion had not been met. The debentures are contingently convertible into approximately 8.2 million shares of Genzyme General Stock at an initial conversion price of $70.30 per share.

Biosurgery Stock:

For all periods presented, basic and diluted net loss per share of Biosurgery Stock are the same. We did not include the securities described in the following table in the computation of Biosurgery Stock diluted net loss per share for each period because these securities would have an anti-dilutive effect due to the net loss allocated to Biosurgery Stock (amounts in thousands):

	Three Months Ended March 31,
	2003	2002
Shares of Biosurgery Stock issuable for options	7,864	6,694
Warrants to purchase shares of Biosurgery Stock	7	8
Biosurgery designated shares (1)	3,119	3,107
Biosurgery designated shares reserved for options (1)	74	89
Shares issuable upon conversion of the 6.9% convertible subordinated note allocated to Genzyme Biosurgery (2)	358	358

Total shares excluded from the calculation of diluted net loss per share of Biosurgery Stock	11,422	10,256

(1): Biosurgery designated shares are authorized shares of Biosurgery Stock that are not issued and outstanding, but which our board of directors may issue, sell or distribute without allocating the proceeds or benefits to Genzyme Biosurgery. As of March 31, 2003, there were approximately 3.2 million Biosurgery designated shares.
(2): These shares are issuable upon the conversion of the 6.9% convertible subordinated note we assumed in connection with the acquisition of Biomatrix, Inc. in 2000. This note is due May 14, 2003.

Molecular Oncology Stock:

For all periods presented, basic and diluted net loss per share of Molecular Oncology Stock are the same. We did not include the securities described in the following table in the computation of Molecular Oncology Stock diluted net loss per share for each period because these securities would have an anti-dilutive effect due to the net loss allocated to Molecular Oncology Stock (amounts in thousands):

	Three Months Ended March 31,
	2003	2002
Shares of Molecular Oncology Stock issuable for options	3,501	1,534
Molecular Oncology designated shares (1)	1,651	1,651

Total shares excluded from the calculation of diluted net loss per share of Molecular Oncology Stock	5,152	3,185

(1): Molecular Oncology designated shares are authorized shares of Molecular Oncology Stock that are not issued and outstanding, but which our board of directors may issue, sell, or distribute without allocating the proceeds or benefits to Genzyme Molecular Oncology. As of March 31, 2003, there were approximately 1.7 million Molecular Oncology designated shares.

4. Inventories (amounts in thousands)

		March 31, 2003		December 31, 2002
Raw materials		$	53,783	$	45,751
Work-in-process			86,396		77,274
Finished products			86,299		115,784

	Total	$	226,478	$	238,809

We capitalize inventory produced for commercial sale, which may result in the capitalization of inventory that has not yet been approved for sale. If a product is not approved for sale, it would likely result in the write-off of the inventory and a charge to earnings. At March 31, 2003, our total inventories include $8.6 million of inventory for products that have not yet been approved for sale.

We own a 50% interest in our joint venture with BioMarin Pharmaceutical, Inc., or BioMarin, for the development and commercialization of Aldurazyme® enzyme as an enzyme replacement therapy for people with an LSD known as mucopolysaccharidosis I, or MPS I. At March 31, 2003, our joint venture had $23.1 million of Aldurazyme enzyme inventory that had not yet been approved for sale, of which $11.5 million represents our portion of the unapproved inventory of the joint venture. On April 30, 2003, the FDA granted U.S. marketing approval for Aldurazyme enzyme.

5. Goodwill and Other Intangible Assets

Effective January 1, 2002, we adopted SFAS No. 142, "Goodwill and Other Intangible Assets," which requires that ratable amortization of goodwill and certain intangible assets be replaced with periodic tests of goodwill's impairment and that other intangible assets be amortized over their useful lives unless these lives are determined to be indefinite. We are required to perform impairment tests under SFAS No. 142 annually, which we perform in the third quarter, and whenever events or changes in circumstance suggest that the carrying value of an asset may not be recoverable. During the three months ended March 31, 2003, there were no events or circumstances that would have caused an impairment review.

Goodwill

In November 2001, we sold our Snowden-Pencer® line of surgical instruments and recorded a loss of $25.0 million, which we allocated to Genzyme Biosurgery. Our subsequent test of the remaining long-lived assets related to the remaining products of our surgical instruments and medical devices business line, which make up the majority of Genzyme Biosurgery's cardiothoracic reporting unit, under SFAS No. 121, "Accounting for the Impairment of Long-Lived Assets and Long-Lived Assets to be Disposed Of," did not indicate an impairment based on the undiscounted cash flows of the business. However, the impairment analysis indicated that the goodwill allocated to Genzyme Biosurgery's cardiothoracic reporting unit would be impaired if the analysis was done using discounted cash flows, as required by SFAS No. 142. Therefore, upon adoption of SFAS No. 142, we tested the goodwill of Genzyme Biosurgery's cardiothoracic reporting unit in accordance with the transitional provisions of that standard, using the present value of expected future cash flows to estimate the fair value of this reporting unit. We recorded an impairment charge of $98.3 million, which we reflected as a cumulative effect of a change in accounting for goodwill in our consolidated statements of operations and the

combined statements of operations for Genzyme Biosurgery for the three months ended March 31, 2002.

Effective January 1, 2002, in accordance with the provisions of SFAS No. 142, we ceased amortizing goodwill. The following table provides information on the changes in our net goodwill during the three months ended March 31, 2003 (amounts in thousands):

				As of December 31, 2002			Adjustments		As of March 31, 2003
Goodwill:
	Genzyme General:
		Therapeutics		$	380,854		$	—	$	380,854
		Renal			82,477			—		82,477
		Diagnostic Products (1)			33,216			2		33,218
		Other (1)			56,633			12		56,645

			Total		553,180			14		553,194
	Genzyme Biosurgery				122,271			—		122,271
	Genzyme Molecular Oncology				—			—		—

			Total		675,451			14		675,465
Accumulated amortization					(83,376	)		—		(83,376	)

Goodwill, net				$	592,075		$	14	$	592,089

(1): The adjustments to goodwill for the three months ended March 31, 2003 relate to foreign currency adjustments on goodwill denominated in foreign currencies.

Other Intangible Assets

The following table contains information on our other intangible assets for the periods presented (amounts in thousands):

		As of March 31, 2003							As of December 31, 2002
		Gross Other Intangible Assets		Accumulated Amortization			Net Other Intangible Assets		Gross Other Intangible Assets		Accumulated Amortization			Net Other Intangible Assets
Technology		$	551,846	$	(99,212	)	$	452,634	$	551,836	$	(88,222	)	$	463,614
Patents			196,997		(40,801	)		156,196		196,997		(37,014	)		159,983
Trademarks			91,754		(17,441	)		74,313		91,754		(15,945	)		75,809
License fees			26,862		(7,742	)		19,120		26,862		(7,261	)		19,601
Distribution agreements			13,950		(3,987	)		9,963		13,950		(3,550	)		10,400
Customer lists			8,324		(4,239	)		4,085		8,324		(4,031	)		4,293
Other			11,602		(10,953	)		649		12,242		(11,464	)		778

	Total	$	901,335	$	(184,375	)	$	716,960	$	901,965	$	(167,487	)	$	734,478

All of our other intangible assets are amortized over their estimated useful lives, which range between 1.5 years to 40 years. Total amortization expense for our other intangible assets was:

•: $17.5 million for the three months ended March 31, 2003; and
•: $17.9 million for the three months ended March 31, 2002.

Amortization expense for the three months ended March 31, 2002 includes $0.3 million related to the amortization of a non-compete agreement that was charged to cost of products sold. This agreement concluded and the related intangible asset was fully amortized as of December 31, 2002.

The estimated future amortization expense for other intangible assets as of March 31, 2003 for the remainder of fiscal year 2003 and the five succeeding fiscal years is as follows (amounts in thousands):

Year Ended December 31,	Estimated Amortization Expense
2003 (remaining nine months)	$	52,638
2004		69,725
2005		69,205
2006		66,703
2007		66,633
2008		65,817

6. Sale of GTC Common Stock

On April 4, 2002, GTC Biotherapeutics, Inc., formerly known as Genzyme Transgenics Corporation and which we refer to as GTC, purchased approximately 2.8 million shares of GTC common stock held by us and allocated to Genzyme General for an aggregate consideration of $9.6 million. We received $4.8 million in cash and a promissory note for the remaining amount. The shares of GTC common stock sold were valued at $3.385 per share in this transaction, using the simple average of the high and low transaction prices quoted on the Nasdaq National Market on April 1, 2002. We have committed to a 24-month lock-up provision on the remaining 4.9 million shares of GTC common stock held by us and allocated to Genzyme General, which is approximately 18% of the shares of GTC common stock outstanding as of March 31, 2003. We accounted for our investment in GTC under the equity method of accounting until May 2002, at which point our ownership interest and board representation was reduced below 20% and we did not have any other factors of significant influence. Accordingly, we ceased to have significant influence over GTC and we began accounting for our investment in GTC under the cost method of accounting in June 2002. Equity in net loss of unconsolidated affiliates in our consolidated statements of operations and the combined statements of operations of Genzyme General for the three months ended March 31, 2002 includes charges of $1.1 million representing our portion of the losses of GTC.

7. Investments in Equity Securities

of Genzyme General at cost, subject to review for impairment. Based on the market price of GTC common stock at March 31, 2003, our remaining investment would have an unrealized gain of $1.7 million. Effective April 4, 2003, we will begin the last 12 months of the 24-month lock-up provision and, as a result, the remaining shares of GTC common stock that we hold will qualify as marketable securities under SFAS No. 115 and be carried on our consolidated balance sheets and the combined balance sheets of Genzyme General at fair value.

At March 31, 2003, our stockholders' equity includes $6.3 million of unrealized gains and $8.0 million of unrealized losses related to our other investments in equity securities, all of which are allocated to Genzyme General. We believe the losses related to our other investments in equity securities are temporary. We will record impairment charges related to these investments if the stocks do not recover within the next three to six months, all of which will be allocated to Genzyme General.

8. Investment in Peptimmune, Inc.

In January 2002, we formed Peptimmune, Inc., or Peptimmune, as our wholly-owned subsidiary, by contributing $5.0 million of cash and $0.3 million of other assets allocated to Genzyme General to Peptimmune in exchange for 5.5 million shares of Peptimmune's Series A voting preferred stock and 100 shares of Peptimmune common stock. We allocated our investment in Peptimmune to Genzyme General. We consolidated the results of Peptimmune through February 2003 because during that period we owned 100% of the outstanding stock of Peptimmune. In March 2003, our investment in Peptimmune decreased to approximately 12% as a result of the sale by Peptimmune of shares of its Series B voting preferred stock to third party investors. In accordance with our policy pertaining to affiliate sales of stock, we recorded a $2.9 million net gain ($4.5 million pre-tax) due to the issuance by Peptimmune of shares of its Series B voting preferred stock, which was recorded as an increase to our investment in Peptimmune in other noncurrent assets and an increase to other comprehensive income in stockholders' equity in our consolidated balance sheet as of March 31, 2003. Although our ownership interest in Peptimmune has declined below 20%, certain factors exist that cause us to continue to have significant influence over Peptimmune. The chairman, president and chief executive officer of Peptimmune is a member of our board of directors, one of our corporate officers is a consultant to Peptimmune and we have several service agreements with Peptimmune. Accordingly, in March 2003, we began accounting for our investment in Peptimmune under the equity method of accounting.

9. Revolving Credit Facility

We have access to a $350.0 million revolving credit facility, all of which matures in December 2003. At March 31, 2003, $284.0 million was outstanding under this facility, all of which was allocated to Genzyme Biosurgery. Borrowings under this facility bear interest at LIBOR plus an applicable margin, which was, in the aggregate, 2.5% at March 31, 2003. The terms of the revolving credit facility include various covenants, including financial covenants, which require us to meet minimum liquidity and interest coverage ratios and to meet maximum leverage ratios. We currently are in compliance with these covenants. We intend to refinance our revolving credit facility prior to its expiration in December 2003.

10. Other Commitments and Contingencies

In 2001, Genzyme Limited, our wholly-owned subsidiary in the United Kingdom, established a home nursing and infusion service to support patients receiving Cerezyme® enzyme and our other enzyme replacement therapies following the expiration of a contract with a third party service provider. This third party lodged a complaint with the Office of Fair Trading in the United Kingdom. The OFT is a non-governmental organization empowered to enforce certain consumer and competition legislation in the United Kingdom. The OFT commenced an investigation of this service, alleging that it contravened competition laws in the United Kingdom. While we believe that the provision of home healthcare services by our subsidiary and our pricing for Cerezyme enzyme in the United Kingdom fully complies with applicable laws, we cooperated in this investigation. On March 27, 2003, the OFT ruled that this service did, in fact, violate United Kingdom competition law, and as a result fined Genzyme Limited approximately 6.8 million Pounds Sterling and required modifications to our pricing structure for Cerezyme enzyme in the United Kingdom. We have appealed this finding to the United Kingdom Competition Appeal Tribunal, receiving an automatic stay of the fine, and seeking a stay of the order on Cerezyme pricing. Hearings were held on April 16, 2003 and May 1, 2003 regarding the stay of the OFT's decision. On May 6, 2003, the Tribunal issued an order that stays the OFT's decision but which requires Genzyme Limited to provide one supplier a modest discount during the pendancy of the appeal process. We are confident that we will prevail on appeal and believe it probable that we will not have to pay a material fine or permanently modify our Cerezyme pricing structure. We have not accrued any amounts in connection with this contingency.

The staff of the FTC is investigating our acquisition of Novazyme Pharmaceuticals, Inc. The FTC is one of the agencies responsible for enforcing federal antitrust laws. While we do not believe that the acquisition should be deemed to contravene antitrust laws, we have been cooperating with the FTC in its investigation which is currently ongoing.

On April 17, 2002, Snowden Pencer, Inc., or SPI, initiated dispute resolution procedures alleging that we breached representations and warranties and committed fraud and intentional conduct relating to the sale of our Snowden-Pencer line of surgical instruments to SPI in November 2001. On April 7, 2003, SPI filed a notice of arbitration with the American Arbitration Association. An arbitration hearing is anticipated to take place within the next 60-90 days. We believe the claims made by SPI are without merit and intend to vigorously defend the claims. Based on the advice of counsel, management does not believe that it is probable that we will be required to pay a material amount in connection with this claim. We have not accrued any amounts in connection with this contingency.

Pursuant to the terms of our joint venture agreement with BioMarin, we are obligated to pay BioMarin a $12.1 million milestone payment upon receipt of U.S. marketing approval from the FDA for Aldurazyme enzyme. On April 30, 2003, the FDA granted U.S. marketing approval for Aldurazyme enzyme.

Guarantees

In November 2002, the FASB issued FIN 45 "Guarantor's Accounting and Disclosure Requirements for Guarantees, Including Indirect Guarantees of Indebtedness of Others—an

interpretation of FASB Statements No. 5, 57 and 107 and rescission of FASB Interpretation No. 34." FIN 45 clarifies that a guarantor is required to recognize, at the inception of a guarantee, a liability for the fair value of the obligation undertaken in issuing certain guarantees. FIN 45 also requires additional disclosures to be made by a guarantor in its interim and annual financial statements about its obligations under certain guarantees it has issued. The accounting requirements for the initial recognition of guarantees are applicable on a prospective basis for guarantees issued or modified after December 31, 2002. The disclosure requirements are effective for all guarantees outstanding, regardless of when they were issued or modified, beginning with periods ending after December 15, 2002. We applied the disclosure provisions of FIN 45 as of December 31, 2002, as required.

We have agreements whereby we indemnify our officers and directors for certain events or occurrences while the officer or director is, or was serving, at our request in such capacity. The term of the indemnification period is for the officer's or director's lifetime. The maximum potential amount of future payments we could be required to make under these indemnification agreements is unlimited; however, we have a Director and Officer insurance policy that limits our exposure and enables us to recover a portion of any future amounts paid. As a result of our insurance policy coverage, we believe the estimated fair value of these indemnification agreements is minimal. We have no liabilities recorded for these agreements as of March 31, 2003.

We enter into standard indemnification agreements in our ordinary course of business. Pursuant to these agreements, we indemnify, hold harmless, and agree to reimburse the indemnified parties for losses suffered or incurred by the indemnified parties, generally our business partners or customers, in connection with any U.S. patent, or any copyright or other intellectual property infringement claim by any third party with respect to our products. The term of these indemnification agreements is generally perpetual any time after execution of the agreement. The maximum potential amount of future payments we could be required to make under these indemnification agreements is unlimited. We have no liabilities recorded for these agreements as of March 31, 2003.

11. Tax Provision

	Three Months Ended March 31,
	Three Months Ended March 31,						Increase/ (Decrease) % Change
	2003			2002			Increase/ (Decrease) % Change
	(Amounts in thousands, except percentage data)
Provision for income taxes	$	(18,998	)	$	(3,138	)	505	%
Effective tax rate		30	%		32	%

Our tax rates for both periods vary from the U.S. statutory tax rate as a result of our:

•: provision for state income taxes;
•: tax benefits from export sales; and
•: use of tax credits.

12. Common Stock

As required under our charter, on January 1, 2003, the number of votes associated with a share of Biosurgery Stock and a share of Molecular Oncology Stock were adjusted so that for the period from January 1, 2003 through December 31, 2004, each share of Biosurgery Stock will entitle the holder to .08 of a vote, and each share of Molecular Oncology Stock will entitle the holder to .07 of a vote. A share of Genzyme General Stock continues to entitle its holder to 1 vote.

13. Segment Information

In accordance with SFAS No. 131, "Disclosures about Segments of an Enterprise and Related Information," we present segment information in a manner consistent with the method we use to report this information to our management. Applying SFAS No. 131, we have five reportable segments:

•: Therapeutics, which develops, manufactures and distributes human therapeutic products with an expanding focus on products to treat patients suffering from genetic diseases and other chronic debilitating diseases, including a family of diseases known as LSDs, and other specialty therapeutics. The segment derives substantially all of its revenue from sales of Cerezyme enzyme, Fabrazyme® enzyme and Thyrogen® hormone;
•: Renal, which develops products that treat patients suffering from renal diseases, including chronic renal failure. The segment derives substantially all of its revenue from sales of Renagel® phosphate binder;
•: Diagnostic Products, which provides diagnostic products to niche markets focusing on in vitro diagnostics;
•: Genzyme Biosurgery, which develops and markets biotherapeutic and biomaterial products, with an emphasis on products that meet medical needs in the orthopaedics, cardiovascular and broader surgical areas; and
•: Genzyme Molecular Oncology, which is developing a new generation of cancer products focused on cancer vaccines and angiogenesis inhibitors through the integration of its genomics, gene and cell therapy, small molecule drug discovery and protein therapeutic capabilities.

We have provided information concerning the operations in these reportable segments in the following table (amounts in thousands):

				Three Months Ended March 31,
				2003			2002
Revenues:
	Genzyme General:
		Therapeutics		$	197,211		$	161,307
		Renal (1)			58,766			29,532
		Diagnostic Products			23,196			19,838
		Other (2)			34,364			30,787
		Eliminations/Adjustments (3)			508			683

			Total Genzyme General		314,045			242,147
	Genzyme Biosurgery				65,626			53,371
	Genzyme Molecular Oncology				2,188			2,422

			Total	$	381,859		$	297,940

Net income (loss):
	Genzyme General:
		Therapeutics		$	51,132		$	31,842
		Renal (1)			3,795			(5,127	)
		Diagnostic Products			1,962			(1,445	)
		Other (2)			1,345			2,191
		Eliminations/Adjustments (3)			(441	)		(3,152	)

			Net income for Genzyme General		57,793			24,309

	Genzyme Biosurgery:
		Net loss for Genzyme Biosurgery before cumulative effect of change in accounting for goodwill			(14,102	)		(20,382	)
		Cumulative effect of change in accounting for goodwill (4)			—			(98,270	)

			Net loss for Genzyme Biosurgery		(14,102	)		(118,652	)

	Genzyme Molecular Oncology				(4,815	)		(6,031	)

	Eliminations/Adjustments (5)				6,493			8,877

			Total	$	45,369		$	(91,497	)

(1): In September 2002, we created our Renal reporting segment consisting primarily of amounts attributable to the manufacture and sale of Renagel phosphate binder and amounts attributable to our research and development programs focused on renal diseases. Previously, amounts attributable to the manufacture and sale of Renagel phosphate binder had been included as a component of our Therapeutics reporting

segment and amounts attributable to our renal research and development programs had been included in Eliminations/Adjustments for Genzyme General. We have reclassified our segment disclosures for the three months ended March 31, 2002 to conform to the presentation for the three months ended March 31, 2003.

(2): Other includes amounts attributable to our genetic testing and pharmaceutical businesses, both of which operate within Genzyme General.
(3): Eliminations/Adjustments consist primarily of amounts related to Genzyme General's research and development and administrative activities, including investment income and interest expense, that we do not specifically allocate to a particular segment of Genzyme General.
(4): In connection with the adoption of SFAS No. 142 on January 1, 2002, we tested the goodwill of Genzyme Biosurgery's cardiothoracic reporting unit for impairment and, as a result, reduced goodwill by recording a cumulative effect impairment charge of $98.3 million in our consolidated statements of operations and the combined statements of operations of Genzyme Biosurgery for the three months ended March 31, 2002.
(5): Includes income tax benefits that have not been recognized in the tax provisions of the divisions.

Segment Assets

We provide information concerning the assets of our reportable segments in the following table (amounts in thousands):

				March 31, 2003			December 31, 2002
Segment Assets:
	Genzyme General (1):
		Therapeutics		$	1,103,664		$	1,127,493
		Renal			474,859			467,164
		Diagnostic Products			103,395			103,636
		Other (2)			88,620			89,705
		Eliminations/Adjustments (3)			1,884,371			1,767,803

			Total Genzyme General		3,654,909			3,555,801
	Genzyme Biosurgery				541,563			560,792
	Genzyme Molecular Oncology				7,428			13,981
	Eliminations/Adjustments (4)				(39,659	)		(47,525	)

			Total	$	4,164,241		$	4,083,049

(1): Segment assets for Genzyme General include primarily cash, cash equivalents, investments, accounts receivable, inventory and certain fixed and intangible assets.
(2): Other includes amounts attributable to our genetic testing and pharmaceutical businesses, both of which operate within Genzyme General.

(3): Eliminations/Adjustments for Genzyme General consists primarily of cash, cash equivalents, short-and long- term investments, equity investments, net property, plant and equipment and deferred tax assets that we do not allocate to a particular segment of Genzyme General.
(4): Represents primarily the elimination of inter-divisional balances.

GENZYME GENERAL

A Division of Genzyme Corporation

Combined Statements of Operations

(Unaudited, amounts in thousands)

				Three Months Ended March 31,
				2003			2002
Revenues:
	Net product sales			$	289,039		$	218,463
	Net service sales				24,455			21,175
	Revenues from research and development contracts:
		Related parties			438			612
		Other			113			1,897

			Total revenues		314,045			242,147

Operating costs and expenses:
	Cost of products sold				69,576			47,599
	Cost of services sold				13,464			11,866
	Selling, general and administrative				85,246			76,390
	Research and development (including research and development related to contracts)				56,329			63,836
	Amortization of intangibles				9,736			9,718

			Total operating costs and expenses		234,351			209,409

Operating income					79,694			32,738

Other income (expenses):
	Equity in net loss of unconsolidated affiliates				(4,194	)		(4,094	)
	Gain on investments in equity securities				—			166
	Other				780			(897	)
	Investment income				11,281			12,952
	Interest expense				(4,277	)		(4,541	)

			Total other income		3,590			3,586

Income before income taxes					83,284			36,324
Provision for income taxes					(25,491	)		(12,015	)

Division net income				$	57,793		$	24,309

Comprehensive income (loss) net of tax:
	Division net income			$	57,793		$	24,309

	Other comprehensive income (loss), net of tax:
		Foreign currency translation adjustments			13,404			(5,363	)
		Gain on affiliate sale of stock, net of tax			2,856			—
		Unrealized gains (losses) on securities, net of tax			4,046			(23,865	)
		Other			69			378

	Other comprehensive income (loss)				20,375			(28,850	)

Comprehensive income (loss)				$	78,168		$	(4,541	)

The accompanying notes are an integral part of these unaudited, combined financial statements.

GENZYME GENERAL

A Division of Genzyme Corporation

Combined Balance Sheets

(Unaudited, amounts in thousands)

			March 31, 2003		December 31, 2002
ASSETS
Current assets:
	Cash and cash equivalents		$	378,111	$	372,605
	Short-term investments			108,333		94,339
	Accounts receivable, net			274,632		251,318
	Inventories			184,932		196,396
	Prepaid expenses and other current assets			43,184		42,558
	Due from Genzyme Biosurgery			27,350		32,641
	Due from Genzyme Molecular Oncology			5,033		5,494
	Deferred tax assets			104,622		105,094

		Total current assets		1,126,197		1,100,445
Property, plant and equipment, net				779,199		749,840
Long-term investments				719,127		682,201
Notes receivable—related parties				12,021		11,918
Goodwill, net				481,713		481,699
Other intangible assets, net				441,927		451,661
Investments in equity securities				52,246		42,945
Due from Genzyme Biosurgery—noncurrent				8,821		9,390
Other noncurrent assets				33,658		25,702

		Total assets	$	3,654,909	$	3,555,801

LIABILITIES AND DIVISION EQUITY
Current liabilities:
	Accounts payable		$	32,622	$	35,978
	Accrued expenses			152,919		170,186
	Income taxes payable			76,079		58,107
	Deferred revenue			15,530		10,588
	Current portion of long-term debt and capital lease obligations			18		13

		Total current liabilities		277,168		274,872
Long-term debt and capital lease obligations				25,026		25,038
Convertible debentures				575,000		575,000
Deferred revenue—noncurrent				3,611		—
Deferred tax liability				80,836		81,933
Other noncurrent liabilities				13,238		13,074

		Total liabilities		974,879		969,917
Commitments and contingencies (Note 9)
Division equity				2,680,030		2,585,884

		Total liabilities and division equity	$	3,654,909	$	3,555,801

The accompanying notes are an integral part of these unaudited, combined financial statements.

GENZYME GENERAL

A Division of Genzyme Corporation

Combined Statements of Cash Flows

(Unaudited, amounts in thousands)

					Three Months Ended March 31,
					2003			2002
Cash Flows from Operating Activities:
	Division net income				$	57,793		$	24,309
	Reconciliation of division net income to net cash from operating activities:
		Depreciation and amortization				26,256			21,981
		Non-cash compensation expense				242			392
		Provision for bad debts				949			1,968
		Equity in net loss of unconsolidated affiliates				4,194			4,094
		Gain on investments in equity securities				—			(166	)
		Deferred income tax benefit				(2,556	)		(3,802	)
		Other				757			2,068
		Increase (decrease) in cash from working capital changes:
			Accounts receivable			(21,521	)		2,890
			Inventories			12,268			(6,493	)
			Prepaid expenses and other current assets			(361	)		(7,680	)
			Due from Genzyme Biosurgery			5,860			6,270
			Due from Genzyme Molecular Oncology			461			1,194
			Accounts payable, accrued expenses and deferred revenue			(11,602	)		(7,433	)
			Income taxes payable and tax benefits from stock options			22,204			7,792

				Cash flows from operating activities		94,944			47,384

Cash Flows from Investing Activities:
	Purchases of investments					(167,469	)		(105,356	)
	Sales and maturities of investments					114,814			172,867
	Purchases of equity securities					(1,025	)		(1,610	)
	Purchases of property, plant and equipment					(44,952	)		(42,689	)
	Investments in unconsolidated affiliates					(4,112	)		(8,151	)
	Other					(620	)		2,645

				Cash flows from investing activities		(103,364	)		17,706

Cash Flows from Financing Activities:
	Allocated proceeds from issuance of Genzyme General Stock					8,744			11,625
	Payments of debt and capital lease obligations					(9	)		(443	)
	Receipt of NeuroCell joint venture refund from Genzyme Biosurgery					—			27,063
	Bank overdraft					(348	)		(1,664	)
	Other					238			(2,855	)

				Cash flows from financing activities		8,625			33,726

Effect of exchange rate changes on cash						5,301			(1,406	)

Increase in cash and cash equivalents						5,506			97,410
Cash and cash equivalents at beginning of period						372,605			167,253

Cash and cash equivalents at end of period					$	378,111		$	264,663

The accompanying notes are an integral part of these unaudited, combined financial statements

GENZYME GENERAL

A Division of Genzyme Corporation

Notes To Unaudited, Combined Financial Statements

1. Description of Business

Genzyme General is our operating division that develops and markets:

•: therapeutic products, with an expanding focus on products to treat patients suffering from genetic diseases and other chronic debilitatiting diseases, including a family of diseases known as LSDs and other specialty therapeutics;
•: renal products, with a focus on products that treat patients suffering from renal diseases, including chronic renal failure;
•: diagnostic products, with a focus on in vitro diagnostics; and
•: other products and services, such as genetic testing services and pharmaceutical drug materials.

2. Basis of Presentation and Significant Accounting Policies

Basis of Presentation

The unaudited, combined financial statements of Genzyme General for each period include the statements of operations, balance sheets and statements of cash flows of the businesses we allocate to Genzyme General. We also allocate a portion of our corporate operations to Genzyme General using methods described in our allocation policy included in Note A., "Summary of Significant Accounting Policies—Allocation Policy," to Genzyme General's combined financial statements included in Exhibit 13.2 to our 2002 Form 10-K. These unaudited, combined financial statements are prepared using amounts included in our unaudited, consolidated financial statements included in this Form 10-Q. We prepared these unaudited, combined financial statements for Genzyme General following the requirements of the SEC for interim reporting. As permitted under these rules, we condense or omit certain footnotes and other financial information that are normally required by accounting principles generally accepted in the U.S. We have reclassified certain 2002 data to conform to our 2003 presentation.

These financial statements include all normal and recurring adjustments that we consider necessary for the fair presentation of Genzyme General's financial position and operating results. Since these are interim financial statements, you should also read the combined financial statements and notes for Genzyme General included in our 2002 Form 10-K. Revenues, expenses, assets and liabilities can vary from quarter to quarter. Therefore, the results and trends in these interim financial statements may not be indicative of results for future periods.

Accounting for Stock-Based Compensation

In accounting for stock-based compensation, we do not recognize compensation expense for options granted under the provisions of our stock-based compensation plans with fixed terms and an exercise price greater than or equal to the fair market value of the underlying series of our common stock on the date of grant. All stock-based awards to non-employees are accounted for at their fair value in accordance with SFAS No. 123, as amended, and EITF Issue No. 96-18, "Accounting for Equity Instruments that are Issued to Other than Employees for Acquiring, or in Conjunction with Selling, Goods or Services."

In accordance with the disclosure requirements of SFAS No. 148, the following table sets forth Genzyme General's division net income data as if compensation expense for our stock-based compensation plans was determined in accordance with SFAS No. 123, as amended, based on the fair value at the grant dates of the awards (amounts in thousands):

		Three Months Ended March 31,
		2003			2002
Division net income:
	As reported	$	57,793		$	24,309
	Add: stock-based compensation included in as reported, net of tax		153			247
	Deduct: pro forma stock-based compensation expense, net of tax		(12,121	)		(15,773	)

	Pro forma	$	45,825		$	8,783

The effects of applying SFAS No. 123 are not likely to be representative of the effects on reported division net income (loss) in future years. Additional awards in future years are anticipated.

New Accounting Pronouncements

We have included the impact that recently issued accounting standards will have on our financial statements in Note 2., "Basis of Presentation and Significant Accounting Policies—New Accounting Pronouncements," to our consolidated financial statements, which we incorporate by reference into this note.

3. Net Income Per Share

Note 3., "Net Income (Loss) Per Share," to our consolidated financial statements contains information regarding the calculation of earnings per share for each series of our stock using the two-class method. We present earnings per share data only in our consolidated financial statements because Genzyme Corporation is the issuer of the securities. Our divisions do not and cannot issue securities because they are not companies or legal entities.

4. Inventories (amounts in thousands)

		March 31, 2003		December 31, 2002
Raw materials		$	41,514	$	33,934
Work-in-process			77,475		68,441
Finished products			65,943		94,021

	Total	$	184,932	$	196,396

Genzyme General capitalizes inventory produced for commercial sale, which may result in the capitalization of inventory that has not yet been approved for sale. If a product is not approved for

sale, it would likely result in the write-off of the inventory and a charge to earnings. At March 31, 2003, Genzyme General's total inventories include $8.6 million of inventory for products that have not yet been approved for sale.

We own a 50% interest in our joint venture with BioMarin for the development and commercialization of Aldurazyme enzyme as an enzyme replacement therapy for people with an LSD known as MPS I. At March 31, 2003, our joint venture had $23.1 million of Aldurazyme enzyme inventory that had not yet been approved for sale, of which $11.5 million represents our portion of the unapproved inventory of the joint venture. On April 30, 2003, the FDA granted U.S. marketing approval for Aldurazyme enzyme.

5. Goodwill and Other Intangible Assets

Effective January 1, 2002, Genzyme General adopted SFAS No. 142, "Goodwill and Other Intangible Assets," which requires that ratable amortization of goodwill and certain intangible assets be replaced with periodic tests of goodwill's impairment and that other intangible assets be amortized over their useful lives unless these lives are determined to be indefinite. We are required to perform impairment tests under SFAS No. 142 annually, which we perform in the third quarter, and whenever events or changes in circumstances suggest that the carrying value of an asset may not be recoverable. During the three months ended March 31, 2003, there were no events or changes in circumstances that would have caused an impairment review.

Goodwill

Effective January 1, 2002, in accordance with the provisions of SFAS No. 142, Genzyme General ceased amortizing goodwill. The following table provides information on the changes in net goodwill attributable to Genzyme General's reporting segments during the three months ended March 31, 2003 (amounts in thousands):

				As of December 31, 2002			Adjustments		As of March 31, 2003
Goodwill:
	Genzyme General:
		Therapeutics		$	380,854		$	—	$	380,854
		Renal			82,477			—		82,477
		Diagnostic Products (1)			33,216			2		33,218
		Other (1)			56,633			12		56,645

			Total		553,180			14		553,194
Accumulated amortization					(71,481	)		—		(71,481	)

Goodwill, net				$	481,699		$	14	$	481,713

(1): The adjustments to goodwill during the three months ended March 31, 2003 relate to foreign currency adjustments on goodwill denominated in foreign currencies.

Other Intangible Assets

The following table contains information on Genzyme General's other intangible assets for the periods presented (amounts in thousands):

		As of March 31, 2003							As of December 31, 2002
		Gross Other Intangible Assets		Accumulated Amortization			Net Other Intangible Assets		Gross Other Intangible Assets		Accumulated Amortization			Net Other Intangible Assets
Technology		$	378,467	$	(63,333	)	$	315,134	$	378,457	$	(56,294	)	$	322,163
Patents			117,574		(18,814	)		98,760		117,574		(16,863	)		100,711
Trademarks			6,526		(999	)		5,527		6,526		(890	)		5,636
License fees			25,972		(7,551	)		18,421		25,972		(7,114	)		18,858
Customer lists			8,324		(4,239	)		4,085		8,324		(4,031	)		4,293
Other			10,045		(10,045	)		—		10,045		(10,045	)		—

	Total	$	546,908	$	(104,981	)	$	441,927	$	546,898	$	(95,237	)	$	451,661

All of Genzyme General's other intangible assets are amortized over their estimated useful lives, which range between 1.5 years to 40 years. Total amortization expense for Genzyme General's other intangible assets was:

•: $9.7 million for the three months ended March 31, 2003; and
•: $10.0 million for the three months ended March 31, 2002.

The estimated future amortization expense for Genzyme General's other intangible assets as of March 31, 2003 for the remainder of fiscal year 2003 and the five succeeding fiscal years is as follows (amounts in thousands):

Year Ended December 31,	Estimated Amortization Expense
2003 (remaining nine months)	$	29,270
2004		38,937
2005		38,844
2006		36,478
2007		36,475
2008		35,764

6. Sale of GTC Common Stock

On April 4, 2002, GTC purchased approximately 2.8 million shares of GTC common stock held by us and allocated to Genzyme General for an aggregate consideration of $9.6 million. We received

$4.8 million in cash and a promissory note for the remaining amount. The shares of GTC common stock sold were valued at $3.385 per share in this transaction, using the simple average of the high and low transaction prices quoted on the Nasdaq National Market on April 1, 2002. We have committed to a 24-month lock-up provision on the remaining 4.9 million shares of GTC common stock held by us and allocated to Genzyme General, which is approximately 18% of the shares of GTC common stock outstanding as of March 31, 2003. We accounted for our investment in GTC under the equity method of accounting until May 2002, at which point our ownership interest and board representation was reduced below 20% and we did not have any other factors of significant influence. Accordingly, we ceased to have significant influence over GTC and we began accounting for our investment in GTC under the cost method of accounting in June 2002. Equity in net loss of unconsolidated affiliates in our consolidated statements of operations and the combined statements of operations of Genzyme General for the three months ended March 31, 2002 includes charges of $1.1 million representing our portion of the losses of GTC.

7. Investments in Equity Securities

Because we are within the first 12 months of the 24-month lock-up provision described above, the remaining 4.9 million shares of GTC common stock held by us do not qualify as marketable securities under SFAS No. 115, "Accounting for Certain Investments in Debt and Equity Securities." As a result, we carry our investment in GTC on our consolidated balance sheets and the combined balance sheets of Genzyme General at cost, subject to review for impairment. Based on the market price of GTC common stock at March 31, 2003, our remaining investment would have an unrealized gain of $1.7 million. Effective April 4, 2003, we will begin the last 12 months of the 24-month lock-up provision and, as a result, the remaining shares of GTC common stock that we hold will qualify as marketable securities under SFAS No. 115 and be carried on our consolidated balance sheets and the combined balance sheets of Genzyme General at fair value.

At March 31, 2003, Genzyme General's division equity includes $6.3 million of unrealized gains and $8.0 million of unrealized losses related to our other investments in equity securities, all of which are allocated to Genzyme General. We believe the losses related to our other investments in equity securities are temporary. Genzyme General will record impairment charges related to these investments if the stocks do not recover within the next three to six months, all of which will be allocated to Genzyme General.

8. Investment in Peptimmune

In January 2002, we formed Peptimmune, as our wholly-owned subsidiary, by contributing $5.0 million of cash and $0.3 million of other assets allocated to Genzyme General to Peptimmune in exchange for 5.5 million shares of Peptimmune's Series A voting preferred stock and 100 shares of Peptimmune common stock. We allocated our investment in Peptimmune to Genzyme General, which consolidated the results of Peptimmune through February 2003 because during that period we owned 100% of the outstanding stock of Peptimmune. In March 2003, our investment in Peptimmune decreased to approximately 12% as a result of the sale by Peptimmune of shares of its Series B voting preferred stock to third party investors. In accordance with our policy pertaining to affiliate sales of stock, we recorded a $2.9 million net gain ($4.5 million pre-tax) due to the issuance by Peptimmune of shares of its Series B voting preferred stock, which was recorded as an increase to Genzyme General's

investment in Peptimmune in other noncurrent assets and an increase to other comprehensive income in division equity in Genzyme General's combined balance sheet as of March 31, 2003. Although our ownership interest in Peptimmune has declined below 20%, certain factors exist that cause us to continue to have significant influence over Peptimmune. The chairman, president and chief executive officer of Peptimmune is a member of our board of directors, one of our corporate officers is a consultant to Peptimmune and we have several service agreements with Peptimmune. Accordingly, in March 2003, Genzyme General began accounting for our investment in Peptimmune under the equity method of accounting.

9. Other Commitments and Contingencies

We periodically become subject to legal proceedings and claims arising in connection with our business. We do not believe that there were any asserted claims against us as of March 31, 2003 which, if adversely decided, would have a material adverse effect on Genzyme General's results of operations, financial condition or liquidity. For more information regarding legal proceedings and claims, we suggest that you read Note 10., "Other Commitments and Contingencies," to our consolidated financial statements. We incorporate that information into this note by reference.

Guarantees

In November 2002, the FASB issued FIN 45, "Guarantor's Accounting and Disclosure Requirements for Guarantees, Including Indirect Guarantees of Indebtedness of Others—an interpretation of FASB Statements No. 5, 57 and 107 and rescission of FASB Interpretation No. 34." Genzyme General applied the disclosure provisions of FIN 45 as of December 31, 2002. For more information, we suggest that you read Note 10., "Other Commitments and Contingencies—Guarantees," to our consolidated financial statements. We incorporate that information into this note by reference.

10. Tax Provision

	Three Months Ended March 31,
	Three Months Ended March 31,						Increase/ (Decrease) % Change
	2003			2002			Increase/ (Decrease) % Change
	(Amounts in thousands, except percentage data)
Provision for income taxes	$	(25,491	)	$	(12,015	)	112	%
Effective tax rate		31	%		33	%

Genzyme General's tax rates for all periods vary from the U.S. statutory tax rate as a result of its:

•: provision for state income taxes;
•: tax benefits from export sales; and
•: use of tax credits.

11. Segment Information

In accordance with SFAS No. 131,"Disclosures about Segments of an Enterprise and Related Information", we present segment information for Genzyme General in a manner consistent with the method we use to report this information to our management. Applying SFAS No. 131, Genzyme General has three reportable segments:

•: Therapeutics, which develops, manufactures and distributes human therapeutic products with an expanding focus on products to treat patients suffering from genetic diseases and other chronic debilitating diseases, including a family of diseases known as LSDs, and other specialty therapeutics. The business derives substantially all of its revenue from sales of Cerezyme enzyme, Fabrazyme enzyme and Thyrogen hormone;
•: Renal, which develops products that treat patients suffering from renal diseases, including chronic renal failure. The segment derives substantially all of its revenue from sales of Renagel phosphate binder; and
•: Diagnostic Products, which provides diagnostic products to niche markets focusing on in vitro diagnostics.

We have provided information concerning the operations in these reportable segments in the following table (amounts in thousands):

			Three Months Ended March 31,
			2003			2002
Revenues:
	Therapeutics		$	197,211		$	161,307
	Renal (1)			58,766			29,532
	Diagnostic Products			23,196			19,838
	Other (2)			34,364			30,787
	Eliminations/Adjustments (3)			508			683

		Total	$	314,045		$	242,147

Division net income:
	Therapeutics		$	51,132		$	31,842
	Renal (1)			3,795			(5,127	)
	Diagnostic Products			1,962			(1,445	)
	Other (2)			1,345			2,191
	Eliminations/Adjustments (3)			(441	)		(3,152	)

		Division net income	$	57,793		$	24,309

(1): In September 2002, we created our Renal reporting segment consisting primarily of amounts attributable to the manufacture and sale of Renagel phosphate binder and amounts attributable to our research and development programs focused on renal diseases. Previously, amounts attributable to the manufacture and sale of Renagel phosphate binder had been included as a component of our Therapeutics reporting segment and amounts attributable to our renal research and development programs had

been included in Eliminations/Adjustments for Genzyme General. We have reclassified Genzyme General's segment disclosures for the three months ended March 31, 2002 to conform to the presentation for the three months ended March 31, 2003.

(2): Other includes amounts attributable to our genetic testing and pharmaceutical businesses, both of which operate within Genzyme General.
(3): Eliminations/Adjustments consist primarily of amounts related to Genzyme General's research and development and administrative activities, including investment income and interest expense, that we do not specifically allocate to a particular segment of Genzyme General.

Segment Assets

We provide information concerning the assets of Genzyme General's reportable segments in the following table (amounts in thousands):

			March 31, 2003		December 31, 2002
Segment Assets (1):
	Therapeutics		$	1,103,664	$	1,127,493
	Renal			474,859		467,164
	Diagnostic Products			103,395		103,636
	Other (2)			88,620		89,705
	Eliminations/Adjustments (3)			1,884,371		1,767,803

		Total	$	3,654,909	$	3,555,801

(1): Segment assets for Genzyme General include primarily cash, cash equivalents, investments, accounts receivable, inventory and certain fixed and intangible assets.
(2): Other includes amounts attributable to our genetic testing and pharmaceutical businesses, both of which operate within Genzyme General.
(3): Eliminations/Adjustments for Genzyme General consist primarily of cash, cash equivalents, short-and long-term investments, equity investments, net property, plant and equipment and deferred tax assets that we do not allocate to a particular segment of Genzyme General.

GENZYME BIOSURGERY

A Division of Genzyme Corporation

Combined Statements of Operations

(Unaudited, amounts in thousands)

			Three Months Ended March 31,
			2003			2002
Revenues:
	Net product sales		$	57,450		$	48,163
	Net service sales			7,043			5,208
	Revenues from research and development contracts			1,133			—

		Total revenues		65,626			53,371

Operating costs and expenses:
	Cost of products sold			25,258			24,555
	Cost of services sold			3,514			3,033
	Selling, general and administrative			27,244			24,499
	Research and development (including research and development related to contracts)			13,939			11,872
	Amortization of intangibles			7,769			7,879

		Total operating costs and expenses		77,724			71,838

Operating loss				(12,098	)		(18,467	)

Other income (expenses):
	Other			(30	)		33
	Investment income			219			297
	Interest expense			(2,193	)		(2,245	)

		Total other expenses		(2,004	)		(1,915	)

Division net loss before cumulative effect of change in accounting for goodwill				(14,102	)		(20,382	)
Cumulative effect of change in accounting for goodwill				—			(98,270	)

Division net loss			$	(14,102	)	$	(118,652	)

Comprehensive loss, net of tax:
	Division net loss		$	(14,102	)	$	(118,652	)
	Other comprehensive income (loss), net of tax:
		Foreign currency translation adjustments		1,369			(3,838	)

Comprehensive loss			$	(12,733	)	$	(122,490	)

The accompanying notes are an integral part of these unaudited, combined financial statements.

GENZYME BIOSURGERY

A Division of Genzyme Corporation

Combined Balance Sheets

(Unaudited, amounts in thousands)

			March 31, 2003		December 31, 2002
ASSETS
Current assets:
	Cash and cash equivalents		$	21,996	$	32,747
	Accounts receivable, net			35,352		35,594
	Inventories			41,546		42,413
	Prepaid expenses and other current assets			2,188		2,015

		Total current assets		101,082		112,769
Property, plant and equipment, net				51,825		52,582
Goodwill, net				110,376		110,376
Other intangible assets, net				275,033		282,817
Investment in equity securities				2,250		—
Other noncurrent assets				997		2,248

		Total assets	$	541,563	$	560,792

LIABILITIES AND DIVISION EQUITY
Current liabilities:
	Accounts payable		$	9,311	$	8,480
	Accrued expenses			24,464		23,665
	Due to Genzyme General			27,350		32,641
	Deferred revenue			2,228		1,126
	Current portion of long-term debt, convertible note and capital lease obligations			294,531		294,724

		Total current liabilities		357,884		360,636
Due to Genzyme General—noncurrent				8,821		9,390
Deferred revenue—noncurrent				—		1,771
Other noncurrent liabilities				2,861		2,772

		Total liabilities		369,566		374,569
Commitments and contingencies (Notes 6, 8)
Division equity				171,997		186,223

		Total liabilities and division equity	$	541,563	$	560,792

The accompanying notes are an integral part of these unaudited, combined financial statements.

GENZYME BIOSURGERY

A Division of Genzyme Corporation

Combined Statements of Cash Flows

(Unaudited, amounts in thousands)

					Three Months Ended March 31,
					2003			2002
Cash Flows from Operating Activities:
	Division net loss				$	(14,102	)	$	(118,652	)
	Reconciliation of division net loss to net cash used in operating activities:
		Depreciation and amortization				9,348			9,535
		Provision for bad debts				170			195
		Other				(154	)		(98	)
		Cumulative effect of change in accounting for goodwill				—			98,270
		Increase (decrease) in cash from working capital changes:
			Accounts receivable			286			406
			Inventories			1,085			2,834
			Prepaid expenses and other current assets			(147	)		(44	)
			Accounts payable and accrued expenses			(2,815	)		(2,211	)
			Due to Genzyme General			(5,860	)		(6,270	)

				Cash flows from operating activities		(12,189	)		(16,035	)

Cash Flows from Investing Activities:
	Purchase of equity securities					(375	)		—
	Purchases of property, plant and equipment					(800	)		(852	)
	Other					18			52

				Cash flows from investing activities		(1,157	)		(800	)

Cash Flows from Financing Activities:
	Allocated proceeds from issuance of Biosurgery Stock					203			109
	Proceeds from draw on credit facility					—			35,000
	Payments of debt and capital lease obligations					(193	)		(250	)
	Payment of NeuroCell joint venture refund to Genzyme General					—			(27,063	)
	Bank overdraft					2,637			(336	)
	Payments received for notes receivable from stockholders					—			136
	Other					11			2,141

				Cash flows from financing activities		2,658			9,737

Effect of exchange rate changes on cash						(63	)		(510	)

Decrease in cash and cash equivalents						(10,751	)		(7,608	)
Cash and cash equivalents at beginning of period						32,747			38,623

Cash and cash equivalents at end of period					$	21,996		$	31,015

Supplemental disclosure of non-cash transaction:
	Investment in Excigen, Inc.—Note 6.

The accompanying notes are an integral part of these unaudited, combined financial statements.

GENZYME BIOSURGERY

A Division of Genzyme Corporation

Notes to Unaudited, Combined Financial Statements

1. Description of Business

Genzyme Biosurgery is our operating division that develops and markets biotherapeutic and biomaterial products, with an emphasis on products that meet medical needs in the orthopaedics, cardiovascular and broader surgical areas.

2. Basis of Presentation and Significant Accounting Policies

Basis of Presentation

The unaudited, combined financial statements of Genzyme Biosurgery for each period include the statements of operations, balance sheets and statements of cash flows of the businesses we allocate to Genzyme Biosurgery. We also allocate a portion of our corporate operations to Genzyme Biosurgery using methods described in our allocation policy included in Note A., "Summary of Significant Accounting Policies—Allocation Policy," to Genzyme Biosurgery's combined financial statements included in Exhibit 13.3 to our 2002 Form 10-K. These unaudited, combined financial statements are prepared using amounts included in our unaudited, consolidated financial statements included in this Form 10-Q. We prepared these unaudited, combined financial statements for Genzyme Biosurgery following the requirements of the SEC for interim reporting. As permitted under these rules, we condense or omit certain footnotes and other financial information that are normally required by accounting principles generally accepted in the U.S. We have reclassified certain 2002 data to conform to our 2003 presentation.

These financial statements include all normal and recurring adjustments that we consider necessary for the fair presentation of Genzyme Biosurgery's financial position and operating results. Since these are interim financial statements, you should also read the combined financial statements and notes for Genzyme Biosurgery included in our 2002 Form 10-K. Revenues, expenses, assets and liabilities can vary from quarter to quarter. Therefore, the results and trends in these interim financial statements may not be indicative of results for future periods.

Accounting for Stock-Based Compensation

In accounting for stock-based compensation, we do not recognize compensation expense for options granted under the provisions of our stock-based compensation plans with fixed terms and an exercise price greater than or equal to the fair market value of the underlying series of our common stock on the date of grant. All stock-based awards to non-employees are accounted for at their fair value in accordance with SFAS No. 123, as amended, and EITF Issue No. 96-18, "Accounting for Equity Instruments that are Issued to Other than Employees for Acquiring, or in Conjunction with Selling, Goods or Services."

In accordance with the disclosure requirements of SFAS No. 148, the following table sets forth Genzyme Biosurgery's division net loss data as if compensation expense for our stock-based

compensation plans was determined in accordance with SFAS No. 123, as amended, based on the fair value at the grant dates of the awards (amounts in thousands):

		Three Months Ended March 31,
		2003			2002
Division net loss:
	As reported	$	(14,102	)	$	(118,652	)
	Deduct: pro forma stock-based compensation expense, net of tax		(1,281	)		(1,689	)

	Pro forma	$	(15,383	)	$	(120,341	)

The effects of applying SFAS No. 123 are not likely to be representative of the effects on reported division net income (loss) in future years. Additional awards in future years are anticipated.

New Accounting Pronouncements

We have included the impact that recently issued accounting standards will have on our financial statements in Note 2, "Basis of Presentation and Significant Accounting Policies—New Accounting Pronouncements," to our consolidated financial statements, which we incorporate by reference into this note.

3. Net Income (Loss) Per Share

4. Inventories (amounts in thousands)

		March 31, 2003		December 31, 2002
Raw materials		$	12,269	$	11,817
Work-in-process			8,921		8,833
Finished products			20,356		21,763

	Total	$	41,546	$	42,413

5. Goodwill and Other Intangible Assets

Effective January 1, 2002, Genzyme Biosurgery adopted SFAS No. 142, "Goodwill and Other Intangible Assets," which requires that ratable amortization of goodwill and certain intangible assets be replaced with periodic tests of goodwill's impairment and that other intangible assets be amortized over

their useful lives unless these lives are determined to be indefinite. We are required to perform impairment tests under SFAS No. 142 annually, which we perform in the third quarter, and whenever events or changes in circumstances suggest that the carrying value of an asset may not be recoverable. During the three months ended March 31, 2003, there were no events or changes in circumstances that would have caused an impairment review.

Goodwill

In November 2001, we sold our Snowden-Pencer line of surgical instruments and recorded a loss of $25.0 million, which we allocated to Genzyme Biosurgery. Our subsequent test of the remaining long-lived assets related to the remaining products of our surgical instruments and medical devices business line, which make up the majority of Genzyme Biosurgery's cardiothoracic reporting unit, under SFAS No. 121, "Accounting for the Impairment of Long-Lived Assets and Long-Lived Assets to be Disposed Of," did not indicate an impairment based on the undiscounted cash flows of the business. However, the impairment analysis indicated that goodwill allocated to Genzyme Biosurgery's cardiothoracic reporting unit would be impaired if the analysis was done using discounted cash flows, as required by SFAS No. 142. Therefore, upon adoption of SFAS No. 142, we tested the goodwill of Genzyme Biosurgery's cardiothoracic reporting unit in accordance with the transitional provisions of that standard, using the present value of expected future cash flows to estimate the fair value of this reporting unit. We recorded an impairment charge of $98.3 million, which we reflected as a cumulative effect of a change in accounting for goodwill in our consolidated statements of operations and the combined statements of operations of Genzyme Biosurgery for the three months ended March 31, 2002.

Effective January 1, 2002, in accordance with the provisions of SFAS No. 142, Genzyme Biosurgery ceased amortizing goodwill. There were no changes in net goodwill attributable to Genzyme Biosurgery's reporting segments in the three months ended March 31, 2003. The following table provides information on net goodwill attributable to Genzyme Biosurgery's reporting segments as of March 31, 2003 (amounts in thousands):

			As of March 31, 2003
Goodwill:
	Orthopaedics		$	113,857
	Biosurgical Specialties			8,414

		Total		122,271
Accumulated amortization				(11,895	)

Goodwill, net			$	110,376

Other Intangible Assets

The following table contains information on Genzyme Biosurgery's other intangible assets for the periods presented (amounts in thousands):

		As of March 31, 2003							As of December 31, 2002
		Gross Other Intangible Assets		Accumulated Amortization			Net Other Intangible Assets		Gross Other Intangible Assets		Accumulated Amortization			Net Other Intangible Assets
Technology		$	173,379	$	(35,879	)	$	137,500	$	173,379	$	(31,928	)	$	141,451
Patents			79,423		(21,987	)		57,436		79,423		(20,151	)		59,272
Trademarks			85,228		(16,442	)		68,786		85,228		(15,055	)		70,173
License fees			890		(191	)		699		890		(147	)		743
Distribution agreements			13,950		(3,987	)		9,963		13,950		(3,550	)		10,400
Other			1,557		(908	)		649		2,197		(1,419	)		778

	Total	$	354,427	$	(79,394	)	$	275,033	$	355,067	$	(72,250	)	$	282,817

All of Genzyme Biosurgery's other intangible assets are amortized over their estimated useful lives, which range from 2 years to 40 years. Total amortization expense for Genzyme Biosurgery's other intangible assets was:

•: $7.8 million for the three months ended March 31, 2003; and
•: $7.9 million for the three months ended March 31, 2002.

The estimated future amortization expense for Genzyme Biosurgery's other intangible assets as of March 31, 2003 for the remainder of fiscal year 2003 and the five succeeding fiscal years is as follows (amounts in thousands):

Year Ended December 31,	Estimated Amortization Expense
2003 (remaining nine months)	$	23,368
2004		30,788
2005		30,361
2006		30,225
2007		30,158
2008		30,053

6. Investment in Excigen, Inc.

In March 2003, we entered into a collaboration with Excigen, Inc., a recently created biotechnology company in Baltimore, Maryland focused on developing gene therapies for treating cardiac arrhythmias. In connection with the collaboration, we acquired 1,440,000 shares of the convertible preferred stock of Excigen and a warrant to acquire an additional 865,882 shares of convertible preferred stock, in exchange for our commitment to provide Excigen with up to $2.3 million in funding and $2.3 million

worth of research, clinical, regulatory and manufacturing services, which services are to be provided by Genzyme Biosurgery. We provided the initial $0.4 million of the cash commitment in March 2003, with the balance of $1.9 million to be paid in future installments. We allocate our ownership interest in Excigen to Genzyme Biosurgery. As a result of our ownership interest, we will account for our investment in Excigen under the equity method of accounting.

7. Revolving Credit Facility

Genzyme Biosurgery has access to a $350.0 million revolving credit facility, all of which matures in December 2003. At March 31, 2003, $284.0 million was outstanding under this facility, all of which was allocated to Genzyme Biosurgery. Borrowings under this facility bear interest at LIBOR plus an applicable margin, which was, in aggregate, 2.5% at March 31, 2003. We intend to refinance our revolving credit facility prior to its expiration in December 2003.

8. Other Commitments and Contingencies

We periodically become subject to legal proceedings and claims arising in connection with our business. We do not believe that there were any asserted claims against us as of March 31, 2003 which, if adversely decided, would have a material adverse effect on Genzyme Biosurgery's results of operations, financial condition or liquidity. For more information regarding legal proceedings and claims, we suggest that you read Note 10., "Other Commitments and Contingencies," to our consolidated financial statements. We incorporate that information into this note by reference.

Guarantees

In November 2002, the FASB issued FIN 45, "Guarantor's Accounting and Disclosure Requirements for Guarantees, Including Indirect Guarantees of Indebtedness of Others—an interpretation of FASB Statements No. 5, 57 and 107 and rescission of FASB Interpretation No. 34." Genzyme Biosurgery applied the disclosure provisions of FIN 45 as of December 31, 2002. For more information, we suggest that you read Note 10, "Other Commitments and Contingencies—Guarantees," to our consolidated financial statements. We incorporate that information into this note by reference.

9. Segment Information

In accordance with SFAS No. 131, "Disclosures about Segments of an Enterprise and Related Information," we present segment information for Genzyme Biosurgery in a manner consistent with the method we use to report this information to our management. Applying SFAS No. 131, Genzyme Biosurgery has four reportable segments:

•: Orthopaedics, which includes Synvisc® viscosupplementation product and Carticel® chondrocytes;
•: Biosurgical Specialties, which includes biomaterial products for the general, cosmetic, and cardiovascular surgery markets, including the Sepra™ products and Epicel® skin grafts;
•: Cardiac Science, which includes cell and gene therapies for such diseases as ischemic heart disease and congestive heart failure; and

•: Cardiac Devices, which includes chest drainage systems, lung sealants, and instruments and closures used in coronary artery bypass, valve replacement, lung and other cardiothoracic surgeries.

We have provided information concerning the operations in these reportable segments in the following table (amounts in thousands):

			Three Months Ended March 31,
			2003			2002
Revenues:
	Orthopaedics		$	32,851		$	24,175
	Biosurgical Specialties			13,763			11,021
	Cardiac Science (1)			32			—
	Cardiac Devices (1)			18,980			18,175

		Total	$	65,626		$	53,371

Gross Margin:
	Orthopaedics		$	23,233		$	15,185
	Biosurgical Specialties			6,895			5,471
	Cardiac Science (1,2)			(471	)		—
	Cardiac Devices (1,2)			7,197			5,127

		Total	$	36,854		$	25,783

(1): In January 2003, as a result of a change in how Genzyme Biosurgery reviews its business, the activities of its former Cardiothoracic reporting segment were reallocated into two separate reporting segments called Cardiac Science and Cardiac Devices. Genzyme Biosurgery has reclassified 2002 disclosures to conform to our 2003 presentation.
(2): Revenues from and costs associated with the sale of FocalSeal®-L surgical sealant are primarily allocated to Genzyme Biosurgery's Cardiac Devices reporting segment. For the three months ended March 31, 2003, in accordance with a change in how Genzyme Biosurgery manages its business, $0.5 million of costs associated with the sale of FocalSeal-L surgical sealant were allocated to Genzyme Biosurgery's Cardiac Science reporting segment. No comparable amounts were allocated to its Cardiac Science reporting segment in the same period of 2002.

Segment Assets

Except for intangible assets, we do not allocate assets within Genzyme Biosurgery for purposes of segment information.

GENZYME MOLECULAR ONCOLOGY

A Division of Genzyme Corporation

Combined Statements of Operations

(Unaudited, amounts in thousands)

			Three Months Ended March 31,
			2003			2002
Revenues:
	Service revenue		$	—		$	300
	Revenue from research and development contracts			1,477			1,469
	Licensing revenue			704			653
	Royalty revenue			7			—

		Total revenues		2,188			2,422

Operating costs and expenses:
	Cost of services sold			—			119
	Cost of revenue from research and development contracts, licensing and royalty revenue			1,172			1,135
	Selling, general and administrative			1,734			2,069
	Research and development			4,191			5,298

		Total operating costs and expenses		7,097			8,621

Operating loss				(4,909	)		(6,199	)

Other income (expenses):
	Investment income			114			188
	Interest expense			(20	)		(20	)

		Total other income		94			168

Division net loss			$	(4,815	)	$	(6,031	)

Comprehensive loss, net of tax:
	Division net loss		$	(4,815	)	$	(6,031	)

	Other comprehensive income (loss), net of tax:
		Foreign currency translation adjustments		1			1
		Unrealized losses on securities, net of tax		(47	)		(92	)

	Other comprehensive loss			(46	)		(91	)

Comprehensive loss			$	(4,861	)	$	(6,122	)

The accompanying notes are an integral part of these unaudited, combined financial statements.

GENZYME MOLECULAR ONCOLOGY

A Division of Genzyme Corporation

Combined Balance Sheets

(Unaudited, amounts in thousands)

			March 31, 2003			December 31, 2002
ASSETS
Current assets:
	Cash and cash equivalents		$	195		$	1,459
	Short-term investments			6,556			11,653
	Accounts receivable, net			51			229
	Prepaid expenses and other current assets			610			614

		Total current assets		7,412			13,955
Equipment, net				16			26

		Total assets	$	7,428		$	13,981

LIABILITIES AND DIVISION EQUITY (DEFICIT)
Current liabilities:
	Accrued expenses		$	649		$	760
	Due to Genzyme General			5,033			5,494
	Deferred revenue			2,988			4,173

		Total liabilities		8,670			10,427
Commitments and contingencies (Note 4)
Division equity (deficit)				(1,242	)		3,554

		Total liabilities and division equity (deficit)	$	7,428		$	13,981

The accompanying notes are an integral part of these unaudited, combined financial statements.

GENZYME MOLECULAR ONCOLOGY

A Division of Genzyme Corporation

Combined Statements of Cash Flows

(Unaudited, amounts in thousands)

					Three Months Ended March 31,
					2003			2002
Cash Flows from Operating Activities:
	Division net loss				$	(4,815	)	$	(6,031	)
	Reconciliation of division net loss to net cash used in operating activities:
		Depreciation				10			31
		Other				15			(150	)
		Increase (decrease) in cash from working capital changes:
			Accounts receivable			178			399
			Prepaid expenses and other current assets			4			103
			Accrued expenses and deferred revenue			(1,296	)		(1,791	)
			Due to Genzyme General			(461	)		(1,194	)

				Cash flows from operating activities		(6,365	)		(8,633	)

Cash Flows from Investing Activities:
	Purchases of investments					—			(12,659	)
	Sales and maturities of investments					5,036			11

				Cash flows from investing activities		5,036			(12,648	)

Cash Flows from Financing Activities:
	Allocated proceeds from issuance of Molecular Oncology Stock					64			2

				Cash flows from financing activities		64			2

Effect of exchange rate changes on cash						1			—

Decrease in cash and cash equivalents						(1,264	)		(21,279	)
Cash and cash equivalents at beginning of period						1,459			41,135

Cash and cash equivalents at end of period					$	195		$	19,856

The accompanying notes are an integral part of these unaudited, combined financial statements.

GENZYME MOLECULAR ONCOLOGY

A Division of Genzyme Corporation

Notes To Unaudited, Combined Financial Statements

1. Business Description

Genzyme Molecular Oncology is our operating division that is developing a new generation of cancer products focused on cancer vaccines and angiogenesis inhibitors through the integration of its genomics, gene and cell therapy, small molecule drug discovery and protein therapeutic capabilities.

2. Basis of Presentation and Significant Accounting Policies

Basis of Presentation

The unaudited, combined financial statements of Genzyme Molecular Oncology for each period include the statements of operations, balance sheets and statements of cash flows of the businesses we allocate to Genzyme Molecular Oncology. We also allocate a portion of our corporate operations to Genzyme Molecular Oncology using methods described in our allocation policy included in Note A., "Summary of Significant Accounting Policies—Allocation Policy," to Genzyme Molecular Oncology's combined financial statements included in Exhibit 13.4 to our 2002 Form 10-K. These unaudited, combined financial statements are prepared using amounts included in our unaudited, consolidated financial statements included in this Form 10-Q. We prepared these unaudited, combined financial statements for Genzyme Molecular Oncology following the requirements of the SEC for interim reporting. As permitted under these rules, we condense or omit certain footnotes and other financial information that are normally required by accounting principles generally accepted in the U.S.

These financial statements include all normal and recurring adjustments that we consider necessary for the fair presentation of Genzyme Molecular Oncology's financial position and operating results. Since these are interim financial statements, you should also read the financial statements and notes for Genzyme Molecular Oncology included in our 2002 Form 10-K. Revenues, expenses, assets and liabilities can vary from quarter to quarter. Therefore, the results and trends in these interim financial statements may not be indicative of results for future periods.

Accounting for Stock-Based Compensation

In accounting for stock-based compensation, we do not recognize compensation expense for options granted under the provisions of our stock-based compensation plans with fixed terms and an exercise price greater than or equal to the fair market value of the underlying series of our common stock on the date of grant. All stock-based awards to non-employees are accounted for at their fair value in accordance with SFAS No. 123, as amended, and EITF Issue No. 96-18, "Accounting for Equity Instruments that are Issued to Other than Employees for Acquiring, or in Conjunction with Selling, Goods or Services."

In accordance with the disclosure requirements of SFAS No. 148, the following table sets forth Genzyme Molecular Oncology's division net loss data as if compensation expense for our stock-based

compensation plans was determined in accordance with SFAS No. 123, as amended, based on the fair value at the grant dates of the awards (amounts in thousands):

		Three Months Ended March 31,
		2003			2002
Division net loss:
	As reported	$	(4,815	)	$	(6,031	)
	Deduct: pro forma stock-based compensation expense, net of tax		(718	)		(936	)

	Pro forma	$	(5,533	)	$	(6,967	)

The effects of applying SFAS No. 123 are not likely to be representative of the effects on reported division net income (loss) in future years. Additional awards in future years are anticipated.

New Accounting Pronouncements

3. Net Income (Loss) Per Share

4. Other Commitments and Contingencies

Guarantees

In November 2002, the FASB issued FIN 45, "Guarantor's Accounting and Disclosure Requirements for Guarantees, Including Indirect Guarantees of Indebtedness of Others—an interpretation of FASB Statements No. 5, 57 and 107 and rescission of FASB Interpretation No. 34." Genzyme Molecular Oncology applied the disclosure provisions of FIN 45 as of December 31, 2002. For more information, we suggest that you read Note 10., "Other Commitments and Contingencies—Guarantees," to our consolidated financial statements. We incorporate that information into this note by reference.

ITEM 2. MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS

When reviewing the discussion below, you should keep in mind the substantial risks and uncertainties that characterize our business. In particular, we encourage you to review the risks and uncertainties described under "Factors Affecting Future Operating Results" in Exhibit 99.2 to our 2002 Form 10-K. These risks and uncertainties could cause our actual results to differ materially from those forecast in forward-looking statements or implied by past results and trends. Forward-looking statements are statements that attempt to project or anticipate future developments in our business; we encourage you to review the examples of forward-looking statements under "Note Regarding Forward-Looking Statements." These statements, like all statements in this report, speak only as of the date of this report (unless another date is indicated), and we undertake no obligation to update or revise the statements in light of future developments.

INTRODUCTION

We are a biotechnology and human healthcare company that develops innovative products and provides services for major unmet medical needs. We have three operating divisions:

•

Genzyme General, which develops and markets:

•: therapeutic products, with an expanding focus on products to treat patients suffering from genetic diseases and other chronic debilitating diseases, including a family of diseases known as LSDs and other specialty therapeutics;
•: renal products, with a focus on products that treat patients suffering from renal diseases, including chronic renal failure;
•: diagnostic products, with a focus on in vitro diagnostics; and
•: other products and services, such as genetic testing services and pharmaceutical drug materials.

•

We have three series of common stock—Genzyme General Division common stock, which we refer to as "Genzyme General Stock," Genzyme Biosurgery Division common stock, which we refer to as "Biosurgery Stock," and Genzyme Molecular Oncology Division common stock, which we refer to as "Molecular Oncology Stock." We also refer to our series of stock as "tracking stock." Unlike typical common stock, each of our tracking stocks is designed to track the financial performance of a specific subset of our business operations and its allocated assets, rather than the operations and assets of our entire company. The chief mechanisms intended to cause each tracking stock to "track" the financial performance of each division are provisions in our charter governing dividends and distributions. The provisions governing dividends provide that our board of directors has discretion to decide if and when to declare dividends, subject to certain limitations. To the extent that the following amount does not exceed the funds that would be legally available for dividends under Massachusetts law, the dividend limit for a stock corresponding to a division is the greater of:

•: the amount that would be legally available for dividends under Massachusetts law if the division were a separate corporation; or

•: the amount by which the greater of the fair value of the division's allocated net assets, or its allocated paid-in capital plus allocated earnings, exceeds its corresponding stock's par value, preferred stock preferences and debt obligations.

The provisions in our charter governing dividends and distributions factor the assets and liabilities and income or losses attributable to a division into the determination of the amount available to pay dividends on the associated tracking stock. In addition, our income tax allocation policy provides that if, at the end of any fiscal quarter, a division cannot use any projected annual tax benefit attributable to it to offset or reduce its current or deferred income tax expense, we allocate the tax benefit to other divisions in proportion to their taxable income without any compensating payments or allocation to the division generating the benefit. Genzyme Biosurgery and Genzyme Molecular Oncology have not yet generated taxable income, and thus have not had the ability to use any projected annual tax benefits. Genzyme General has generated taxable income, providing it with the ability to utilize the tax benefits generated by Genzyme Biosurgery and Genzyme Molecular Oncology. Consistent with our policy, we have allocated the tax benefits generated by Genzyme Biosurgery and Genzyme Molecular Oncology to Genzyme General without making any compensating payments or allocations to the division that generated the benefit.

The losses of Genzyme Biosurgery and Genzyme Molecular Oncology may decline in the future. If these losses do decline, and we expect the losses of Genzyme Biosurgery to do so, the tax benefits allocated to Genzyme General will also decline. In addition, if our board of directors decided to change our tax allocation policy, it could reduce the tax benefits allocated to any division that is profitable at the time the change becomes effective, and reduce the earnings allocated to the associated series of tracking stock. Any change in the earnings allocated to a tracking stock also impacts the amount available to pay dividends for that tracking stock. Currently, Genzyme General is our only profitable division.

Deferred tax assets and liabilities can arise from purchase accounting and relate to a division that does not satisfy the realizability criteria of SFAS No. 109, "Accounting for Income Taxes." Such deferred tax assets and liabilities are allocated to the division to which the acquisition was allocated. As a result, the periodic changes in these deferred tax assets and liabilities do not result in a tax expense or benefit to that division. However, the change in these deferred tax assets and liabilities impacts our consolidated tax provision. Such change is added to division net income for purposes of determining net income allocated to a tracking stock. If our board of directors modified the policy for allocating changes in these deferred tax assets and liabilities, the income attributable to each series of tracking stock could be materially different. As a result of any such changes, the amount available to pay dividends for each of our tracking stocks could also be materially different.

Within these parameters, and other general limits under our charter and Massachusetts law, the amount of any dividend payment will be at the board of directors' discretion. To date, we have never paid or declared a cash dividend on shares of any of our series of common stock, nor do we anticipate doing so in the foreseeable future. Unless declared, no dividends accrue on our tracking stocks.

Our charter also requires that distributions be made to holders of Biosurgery Stock or Molecular Oncology Stock if all or substantially all of the assets allocated to that stock's corresponding division are sold to a third party. This mandatory distribution can be in the form of a dividend, a redemption of the division's related tracking stock or an exchange of that tracking stock for Genzyme General Stock, as chosen by our board of directors in its discretion. The distribution, if by dividend or redemption, must equal in value the net after-tax proceeds received from the sale. If our board of directors chooses to make the distribution by issuing Genzyme General Stock in exchange for the selling division's related tracking stock, then the exchange must be effected at a 10% premium to the corresponding tracking stock's average market price calculated over a ten day period beginning on the first business day following the announcement of the sale.

Shares of Biosurgery Stock and Molecular Oncology Stock are subject to certain exchange and redemption provisions as set forth in our charter. One of the exchange provisions allows our board of directors to exchange, at any time, shares of Biosurgery Stock and/or Molecular Oncology Stock for cash, shares of Genzyme General Stock, or a combination of both, valued at a 30% premium to the fair market value (as defined in our charter) of the series of stock being exchanged. We encourage you to read our charter for a more complete discussion of the mandatory and optional exchange and redemption provisions of our common stock.

To determine earnings per share, we allocate our earnings to each series of our common stock based on the earnings attributable to that series of stock. The earnings attributable to each series of stock is defined in our charter as the net income or loss of the corresponding division determined in accordance with accounting principles generally accepted in the U.S. and as adjusted for tax benefits allocated to or from that division in accordance with our management and accounting policies. Our charter also requires that all of our income and expenses be allocated among our divisions in a reasonable and consistent manner. Our board of directors, however, retains considerable discretion in interpreting and changing the methods of allocating earnings to each series of common stock without shareholder approval. As market or competitive conditions warrant, we may create new series of tracking stock, combine existing tracking stock or change our earnings allocation methodology. Because the earnings allocated to each series of stock are based on the income or losses attributable to each corresponding division, we provide financial statements and management's discussion and analysis for the corporation as well as for each of our divisions to aid investors in evaluating our performance and the performance of each of our divisions.

While each tracking stock is designed to reflect a division's performance, each is common stock of Genzyme Corporation and not of a division. Our divisions are not separate companies or legal entities and therefore do not and cannot issue stock. Holders of tracking stock have no specific rights to assets allocated to the corresponding division. We continue to hold title to all of the assets allocated to the corresponding division and are responsible for all of its liabilities, regardless of what we deem for financial statement presentation purposes as allocated to any division. Holders of each tracking stock, as common stockholders are, therefore subject to the risks of investing in the businesses, assets and liabilities of Genzyme as a whole. For instance, the assets allocated to each division are subject to company-wide claims of creditors, product liability plaintiffs and stockholder litigation. Also, in the event of a Genzyme liquidation, insolvency or similar event, holders of each tracking stock would only have the rights of common stockholders in the combined assets of Genzyme.

CRITICAL ACCOUNTING POLICIES AND SIGNIFICANT ESTIMATES

Our critical accounting policies are set forth under the heading "Management's Discussion and Analysis of Genzyme Corporation and Subsidiaries' Financial Condition and Results of Operations—Critical Accounting Policies and Significant Estimates" in Exhibit 13.1 to our 2002 Form 10-K. There have been no changes to these policies and no significant changes to these estimates since December 31, 2002.

A. RESULTS OF OPERATIONS

The following discussion summarizes the key factors our management believes are necessary for an understanding of our consolidated financial statements.

GENZYME CORPORATION

REVENUES

The components of our total revenues are described in the following table:

		Three Months Ended March 31,
		Three Months Ended March 31,				Increase/ (Decrease) % Change
		2003		2002		Increase/ (Decrease) % Change
		(Amounts in thousands, except percentage data)
Product revenue		$	346,489	$	266,626	30	%
Service revenue			31,498		26,683	18	%

	Total product and service revenue		377,987		293,309	29	%
Research and development revenue			3,872		4,631	(16	)%

	Total revenues	$	381,859	$	297,940	28	%

Product Revenue

We derive product revenue from sales by:

•

Genzyme General of:

•: therapeutic products, including Cerezyme and Fabrazyme enzymes, Thyrogen hormone and WelChol® bile acid binder;
•: Renagel phosphate binder;
•: diagnostic products; and
•: other products.

•

Genzyme Biosurgery of:

•: orthopaedic products, including Synvisc viscosupplementation product;
•: biosurgical specialties products, including Seprafilm® bioresorbable membrane;
•: cardiac science product license fees; and
•: cardiac devices products, including FocalSeal-L surgical sealant and fluid management (chest drainage) systems.

The following table sets forth our product revenue on a segment basis:

				Three Months Ended March 31,
				Three Months Ended March 31,				Increase/ (Decrease) % Change
				2003		2002		Increase/ (Decrease) % Change
				(Amounts in thousands, except percentage data)
Genzyme General:
	Therapeutics:
		Cerezyme enzyme		$	167,187	$	148,066	13	%
		Other therapeutic products			30,024		11,445	162	%

			Total Therapeutics		197,211		159,511	24	%
	Renal				58,766		29,532	99	%
	Diagnostic Products				23,196		19,838	17	%
	Other				9,866		9,582	3	%

			Total product revenue—Genzyme General		289,039		218,463	32	%

Genzyme Biosurgery:
	Orthopaedics				26,354		19,998	32	%
	Biosurgical Specialties				12,104		9,990	21	%
	Cardiac Science				12		—	N/A
	Cardiac Devices				18,980		18,175	4	%

			Total product revenue—Genzyme Biosurgery		57,450		48,163	19	%

			Total product revenues	$	346,489	$	266,626	30	%

Genzyme General—Therapeutics

The increase in our Therapeutics product revenue for the three months ended March 31, 2003, as compared to the same period of 2002, was primarily due to continued growth in sales of Cerezyme enzyme for the treatment of Type 1 Gaucher disease and increased sales of other therapeutic products. Other therapeutic products revenue consists primarily of:

•: sales of Thyrogen hormone, which is an adjunctive diagnostic agent used in the follow-up of patients with well-differentiated thyroid cancer;
•: sales of Fabrazyme enzyme, which is a recombinant form of the human enzyme alpha-galactosidase used for the treatment of Fabry disease; and
•: bulk sales of and royalties earned on sales of WelChol bile acid binder, which is an adjunctive therapy for the reduction of elevated LDL cholesterol in patients with primary hypercholesterolemia.

The growth in sales of Cerezyme enzyme for the three months ended March 31, 2003, as compared to the same period of 2002, was attributable to our continued identification of new Gaucher disease patients worldwide, particularly in Europe, resulting from a significant investment in our global sales and marketing infrastructure. The growth in European sales of Cerezyme enzyme for the period was positively impacted by the weakened U.S. Dollar against the Euro. During the three months ended March 31, 2003, as compared to the same period of 2002, the U.S. Dollar weakened against the Euro on average by approximately 22%, which positively impacted sales of Cerezyme enzyme by $10.5 million. Sales of Cerezyme enzyme were approximately 48% of our total product revenue for the three months ended March 31, 2003 as compared to 56% for the same period of 2002.

Our results of operations are highly dependent on sales of Cerezyme enzyme and a reduction in revenue from sales of this product would adversely affect our results of operations. Revenue from Cerezyme enzyme would be impacted negatively if competitors developed alternative treatments for Gaucher disease and the alternative products gained commercial acceptance. Although orphan drug status for Cerezyme enzyme, which provided us with exclusive marketing rights for Cerezyme enzyme in the U.S., expired in May 2001, we continue to have patents protecting our method of manufacturing Cerezyme enzyme until 2010 and the composition of Cerezyme enzyme as made by that process until 2013. The expiration of market exclusivity and orphan drug status will likely subject Cerezyme enzyme to increased competition, which may decrease the amount of revenue we receive from this product or the growth of that revenue.

We are aware of companies that have initiated efforts to develop competitive products, and other companies may do so in the future. For example, Oxford Glycosciences plc, which we refer to as OGS, is developing Zavesca®, a small molecule drug candidate for the treatment of Type 1 Gaucher disease. Zavesca has been granted orphan drug status in the U.S. for treatment of Type 1 Gaucher and Fabry diseases, and has been designated as an orphan medicinal product in the European Union for the treatment of Type 1 Gaucher disease. In July 2002, the FDA issued a "non approvable" letter to OGS in response to its New Drug Application (NDA) for Zavesca; in November 2002, however, the agency agreed to examine additional data in support of that NDA. OGS filed an amendment to its NDA for Zavesca with additional data in March 2003. Also in November 2002, the European Commission approved OGS's Marketing Authorisation Application (MAA) for Zavesca as an oral therapy for use in patients with mild to moderate Type 1 Gaucher disease for whom enzyme replacement therapy is unsuitable. OGS will be required to submit follow-up safety data on the product as a condition of such approval. In January 2003, a licensee of OGS submitted an application for approval of Zavesca with the Israeli Ministry of Health. To date, virtually all Gaucher disease patients who have received enzyme therapy have experienced strong clinical benefit with few side effects so we do not expect the competition from Zavesca to have a significant impact on our sales of Cerezyme enzyme.

Other therapeutic products revenue consists primarily of sales of Thyrogen hormone, Fabrazyme enzyme and bulk sales of and royalties earned on sales of WelChol bile acid binder. The increase in other therapeutic products revenue for the three months ended March 31, 2003 as compared to the same period of 2002 is attributable to:

•: a 61% increase in sales of Thyrogen hormone to $9.7 million primarily due to increased market penetration, particularly in Europe, where sales increased 126% to $4.1 million;
•: a 193% increase in sales of Fabrazyme enzyme in Europe to $11.6 million partially due to our introduction of the product in several new markets in Europe and our continued program to educate European physicians about Fabry disease and Fabrazyme enzyme; and
•: a 462% increase in royalties earned on sales of WelChol bile acid binder to $8.1 million for the three months ended March 31, 2003 as compared to the same period of 2002. These increases were the result of sales to our U.S. marketing partner, Sankyo Pharma, Inc., which experienced continued market growth of the product in the U.S. during the first quarter of 2003. In October 2002, Merck/Schering-Plough Pharmaceuticals received marketing approval in Germany and FDA approval in the U.S. for its competitive product, ezetimibe, for use alone and with marketed statins for the treatment of elevated cholesterol levels as a second-line therapy. The introduction of this product in the U.S. may adversely affect the future growth of bulk sales of and royalties earned on sales of our Welchol bile acid binder.

Genzyme General—Renal

In September 2002, we created the Renal reporting segment consisting primarily of amounts attributable to the manufacture and sale of Renagel phosphate binder. Previously, amounts attributable

to the manufacture and sale of Renagel phosphate binder had been included as a component of Genzyme General's Therapeutics reporting segment. We have reclassified our 2002 disclosures to conform to our 2003 presentation. We expect sales of Renagel phosphate binder to increase, driven primarily by the continued adoption of the product by nephrologists worldwide. The increase in sales of Renagel phosphate binder will be dependent on several factors, including:

•: acceptance by the medical community of Renagel phosphate binder as the preferred treatment for elevated serum phosphorus levels in end-stage renal disease patients on hemodialysis;
•: our ability to effectively manage wholesaler inventories and the levels of compliance with the inventory management programs we implemented with our wholesalers in 2002;
•: our ability to optimize dosing and improve patient compliance with dosing of Renagel phosphate binder;
•: the availability of reimbursement from third party payors and the extent of coverage;
•: our ability to manufacture sufficient quantities of product to meet demand and to do so at a reasonable price;
•: the results of additional clinical trials for additional indications and expanded labeling;
•: the availability of competing treatments;
•: the efficiencies of our sales force; and
•: the content and timing of our submissions to and decisions by regulatory authorities.

Sales of Renagel phosphate binder increased 99% for the three months ended March 31, 2003, as compared to the same period of 2002, primarily due to increased sales in both the U.S. and Europe. In the first three months of 2003, U.S. sales of Renagel phosphate binder increased 98% to $41.8 million as compared to the same period in 2002, primarily due to:

•: continued strong end-user demand for the product;
•: reductions in domestic wholesaler inventories during 2002 that negatively impacted revenues during that year; and
•: approximately $3 million in sales of bulk sevelamer, the raw material used to formulate Renagel phosphate binder, to Chugai Pharmaceutical Co. Ltd., or Chugai, for which there were no comparable amounts in 2002. Chugai, together with its partner, Kirin Pharmaceutical Co. Ltd., has the right to develop and market Renagel phosphate binder in Japan, China and other Pacific Rim countries, and Chugai plans to launch commercial sales in Japan in the second quarter of 2003. We will continue supplying bulk sevelamer to Chugai and will receive royalties on net sales of the finished product.

The price increase for Renagel phosphate binder, effective in February 2003, did not have a significant impact on sales of the product for the three months ended March 31, 2003. In Europe, sales of Renagel phosphate binder increased 100% for the three months ended March 31, 2003, as compared to the same period of 2002, primarily due to:

•: the expansion of the worldwide Renagel phosphate binder sales force;
•: favorable promotion of published clinical data that has increased international adoption of the product, particularly in Europe, where units sales increased 69%; and
•: a 22% increase in the average exchange rate of the Euro, which positively impacted sales of Renagel phosphate binder by $2.2 million.

During the three months ended March 31, 2003, we obtained reimbursement approval for the 800 mg tablet formulation of Renagel phosphate binder in France, the last major European market where this form of the product had previously been unavailable. In addition, in March 2003, we began shipping Renagel phosphate binder tablets to the European market from our new Current Good Manufacturing Practices, or cGMP, manufacturing facility in Waterford, Ireland, upon receiving approval from the European Agency for the Evaluation of Medicinal Products, or EMEA, to commence production of Renagel phosphate binder at the plant. We anticipate that the FDA will approve production of Renagel phosphate binder at the plant during 2003. Sales of Renagel phosphate binder were approximately 17% of our total product revenue for the three months ended March 31, 2003 as compared to 11% for the same period of 2002.

Diagnostic Products

Diagnostic Products product revenue increased 17% for the three months ended March 31, 2003 as compared to the same period of 2002. The increase was primarily attributable to:

•: an 11% increase in the combined sales of infectious disease testing products, HDL and LDL cholesterol testing products and royalties on product sales by Techne Corporation's biotechnology group to $15.9 million; and
•: a 32% increase in sales of point of care rapid diagnostic tests for pregnancy and infectious diseases to $7.3 million.

Other Product Revenue

Other product revenue increased 3% to $9.9 million for the three months ended March 31, 2003 as compared to the same period of 2002. The increase was primarily attributable to a 4% increase in the combined sales of liquid crystals, lipids, peptides and amino acid derivatives to $7.0 million, offset by a 1% decrease in the sales of hyaluronan-based products to $2.8 million.

Genzyme Biosurgery—Orthopaedics

Orthopaedics product revenue increased 32% to $26.4 million for the three months ended March 31, 2003, as compared to the same period of 2002, primarily due to an increase in sales of Synvisc viscosupplementation product. Synvisc viscosupplementation product sales increased primarily due to increased utilization of the product within the existing customer base as well as the creation of new accounts. We believe that a potentially significant competitor is currently seeking FDA approval for a viscosupplementation product for possible U.S. launch during the second half of 2003 that could have an adverse affect on future sales of Synvisc viscosupplementation product.

Genzyme Biosurgery—Biosurgical Specialties

In January 2003, Genzyme Biosurgery reallocated two suture product lines from its Biosurgical Specialties reporting segment to its Cardiac Devices reporting segment, so that all suture product lines are reflected as components of its Cardiac Devices reporting segment. In addition, Genzyme Biosurgery reallocated its cardiovascular Sepra products from its Cardiac Devices reporting segment to its Biosurgical Specialties reporting segment. We have reclassified Genzyme Biosurgery's 2002 disclosures to conform to its 2003 presentation.

Biosurgical Specialties product revenue increased 21% to $12.1 million for the three months ended March 31, 2003, as compared to the same period of 2002, primarily due to a 23% increase in the sales of Sepra products to $10.4 million primarily due to increased market penetration.

Genzyme Biosurgery—Cardiac Devices

Cardiac Devices product revenue increased 4% to $19.0 million for the three months ended March 31, 2003, as compared to the same period of 2002, primarily due to an 8% increase in the sales of instruments for minimally-invasive and off-pump cardiac surgery to $3.3 million as a result of increased market penetration. Additionally, there was a 21% increase in the combined sales of surgical closures for cardiac surgery and surgical closures sold to original equipment manufacturers to $6.3 million for the three months ended March 31, 2003, as compared to the same period of 2002.

Service Revenue

We derive service revenues from four principal sources:

•: genetic testing services performed by Genzyme General, which is included in its Other reporting segment;
•: Genzyme Biosurgery's Carticel chondrocytes for the treatment of cartilage damage, which are included in its Orthopaedics reporting segment, and Epicel skin grafts, which are included in its Biosurgical Specialties reporting segment; and
•: Genzyme Molecular Oncology's agreement with a pharmaceutical company around an improvement to the SAGE™ technology.

The following table sets forth our service revenues on a segment basis:

			Three Months Ended March 31,
			Three Months Ended March 31,				Increase/ (Decrease) % Change
			2003		2002		Increase/ (Decrease) % Change
			(Amounts in thousands, except percentage data)
Genzyme General—Other			$	24,455	$	21,175	15	%

Genzyme Biosurgery:
	Orthopaedics			6,067		4,177	45	%
	Biosurgical Specialties			973		1,031	(6	)%
	Cardiac Science			3		—	N/A

		Total service revenue—Genzyme Biosurgery		7,043		5,208	35	%

Genzyme Molecular Oncology				—		300	(100	)%

		Total service revenues	$	31,498	$	26,683	18	%

The 15% increase in Genzyme General's other service revenue for the three months ended March 31, 2003, as compared to the same period of 2002, is primarily attributable to:

•: increased sales of molecular genetics (DNA) testing services, primarily due to growth in the cystic fibrosis screening and diagnosis market;
•: increased sales of cancer testing services; and
•: continued growth in the prenatal screening market.

Genzyme Biosurgery's Orthopaedics service revenue increased 45% to $6.1 million for the three months ended March 31, 2003, as compared to the same period of 2002, primarily due to a change in the classification of $1.5 million of reimbursed expenses from partners as service revenue.

The 6% decrease in Genzyme Biosurgery's Biosurgical Specialties service revenue to $1.0 million for the three months ended March 31, 2003 as compared to same period of 2002 is attributable to decreased sales of Epicel skin grafts, which are used to treat victims of severe burns. Sales of Epicel skin grafts are variable based upon a number of unpredictable factors, including the number of severe burn patients and their survival rate prior to treatment with Epicel skin grafts.

Genzyme Molecular Oncology's service revenue for the three months ended March 31, 2002 consists of revenues from the provision of services related to the SAGE genomics technology for which there are no comparable amounts in the same period of 2003. Genzyme Molecular Oncology provides these services sporadically as customers request them. The focus of its SAGE business remains directed to granting licenses to the technology.

International Product and Service Revenue

A substantial portion of our revenue was generated outside of the U.S. Most of these revenues were attributable to sales of Cerezyme enzyme. The following table provides information regarding the change in international product and service revenue as a percentage of total product and service revenue during the periods presented:

	Three Months Ended March 31,
	Three Months Ended March 31,						Increase/ (Decrease) % Change
	2003			2002			Increase/ (Decrease) % Change
	(Amounts in thousands, except percentage data)
International product and service revenue	$	159,420		$	120,221		33	%
% of total product and service revenue		42	%		41	%

International sales of Cerezyme enzyme increased 22% to $94.9 million for the three months ended March 31, 2003, as compared to $77.8 million in the same period of 2002, primarily due to:

•: a 7% increase in international unit sales of Cerezyme enzyme; and
•: a 22% increase in the average exchange rate of the Euro, which positively impacted sales of Cerezyme enzyme by $10.5 million.

International sales of Renagel phosphate binder increased 103% to $16.9 million for the three months ended March 31, 2003, as compared to $8.4 million for the same period of 2002, primarily due to:

•: the expansion of the worldwide Renagel phosphate binder sales force;
•: the introduction of Renagel phosphate binder into several new international markets in 2002;
•: favorable promotion of published clinical data that has increased international adoption of the product, particularly in Europe, where units sales increased 69%; and
•: a 22% increase in the average exchange rate of the Euro, which positively impacted sales of Renagel phosphate binder by $2.2 million.

International sales of Fabrazyme enzyme increased 198% to $11.8 million for the three months ended March 31, 2003, as compared to $4.0 million for the same period of 2002, primarily due to:

•: the introduction of Fabrazyme enzyme into several new markets in Europe in 2002;

•: our continued program to educate European physicians about Fabry disease and Fabrazyme enzyme; and
•: a 22% increase in the average exchange rate of the Euro, which positively impacted sales of Fabrazyme enzyme by $1.8 million.

International product and service revenue as a percent of total product and service revenue increased for the three months ended March 31, 2003, as compared to the same period of 2002, primarily due to the overall increase in international product and service sales and a $15.1 million positive impact on sales resulting from a 22% increase in the average exchange rate of the Euro.

Research and Development Revenue

We derive research and development revenue primarily from:

•: research and development services performed by Genzyme General under collaboration agreements allocated to Genzyme General;
•: research and development services Genzyme General performs on behalf of GTC;
•: research and development services performed by Genzyme Biosurgery under collaboration agreements allocated to Genzyme Biosurgery; and
•: license fees and funded research related to Genzyme Molecular Oncology's programs.

The following table sets forth our research and development revenue on a segment basis:

			Three Months Ended March 31,
			Three Months Ended March 31,				Increase/ (Decrease) % Change
			2003		2002		Increase/ (Decrease) % Change
			(Amounts in thousands, except percentage data)
Genzyme General:
	Therapeutics		$	—	$	1,796	(100	)%
	Other			43		31	39	%
	Eliminations/Adjustments			508		682	(26	)%

		Total research and development revenue—Genzyme General		551		2,509	(78	)%

Genzyme Biosurgery:
	Orthopaedics			430		—	N/A
	Biosurgical Specialties			686		—	N/A
	Cardiac Science			17		—	N/A

		Total research and development revenue—Genzyme Biosurgery		1,133		—	N/A

Genzyme Molecular Oncology				2,188		2,122	3	%

Total research and development revenues			$	3,872	$	4,631	(16	)%

Research and development revenue allocated to Genzyme General is related primarily to research and development activities performed under collaboration agreements. Eliminations/Adjustments includes research and development efforts Genzyme General conducted on behalf of GTC and amounts related to Genzyme General's research and development activities that we do not specifically allocate to a particular segment of Genzyme General.

Research and development revenue for Genzyme Biosurgery's Orthopaedics reporting segment is primarily due to reimbursements received from a partner for development projects associated with Synvisc supplementation product. Research and development revenue for Genzyme Biosurgery's

Biosurgical Specialties reporting segment is primarily due to a milestone payment received for Hylaform® biomaterial product.

Research and development revenue allocated to Genzyme Molecular Oncology is derived from the following sources:

•: technology access fees received from Purdue Pharma, L.P. and Kirin Brewery Company, Ltd., which are recognized over the course of the associated research programs; and
•: research performed by Genzyme Molecular Oncology on behalf of Purdue and Kirin.

The slight increase in research and development revenue allocated to Genzyme Molecular Oncology for the three months ended March 31, 2003, as compared to the same period of 2002, is primarily due to a planned increase in the amount of research performed on behalf of Purdue.

MARGINS

		Three Months Ended March 31,
		Three Months Ended March 31,						Increase/ (Decrease) % Change
		2003			2002			Increase/ (Decrease) % Change
		(Amounts in thousands, except percentage data)
Product margin:
	Genzyme General	$	219,463		$	170,864		28	%
	% of total product revenue		63	%		64	%
	Genzyme Biosurgery	$	32,192		$	23,608		36	%
	% of total product revenue		9	%		9	%
	Total product margin	$	251,655		$	194,472		29	%
	% of total product revenue		73	%		73	%
Service margin:
	Genzyme General	$	10,991		$	9,309		18	%
	% of total service revenue		35	%		35	%
	Genzyme Biosurgery	$	3,529		$	2,175		62	%
	% of total service revenue		11	%		8	%
	Genzyme Molecular Oncology	$	—		$	181		(100	)%
	% of total service revenue		—			1	%
	Total service margin	$	14,520		$	11,665		24	%
	% of total service revenue		46	%		44	%
Total product and service gross margin		$	266,175		$	206,137		29	%
% of total product and service revenue			70	%		70	%

Product Margin

Genzyme General

Genzyme General provides a broad range of healthcare products and services. As a result, Genzyme General's gross margin may vary significantly based on the category of product or service. Sales of therapeutic products, including Cerezyme enzyme, typically result in higher margins than diagnostic products.

The 28% increase in Genzyme General's overall product margin for the three months ended March 31, 2003, as compared to same period of 2002, was primarily attributable to a 32% increase in product revenue. The increase in product margin was primarily attributable to an increase in sales of Therapeutics products, in addition to increased sales of Renal and Diagnostic Products for the three months ended March 31, 2003, as compared to same period of 2002.

Product margin for Genzyme General's Therapeutics reporting segment increased 20% for the three months ended March 31, 2003, as compared to the same period of 2002. This was due to a 24% increase in sales of Therapeutics products primarily attributable to increased sales of Cerezyme enzyme, Thyrogen hormone and Fabrazyme enzyme for the three months ended March 31, 2003, as compared to the same period of 2002. The increase in product margin was offset, in part, by the write off of $2.3 million of Cerezyme enzyme finished goods due to production issues, for which there is no similar write off in the same period of 2002.

Product margin for Genzyme General's Renal reporting segment increased 94% for the three months ended March 31, 2003, as compared to the same period of 2002. This was primarily due to an increase in sales of Renagel phosphate binder for the three months ended March 31, 2003, as compared to the same period in 2002, offset by an increase in the rebate reserve for the product corresponding to an increase in our estimates of the percentage of patients being reimbursed by government programs. In addition, product margin for the Renal reporting segment is impacted by sales of bulk sevelamer, a lower margin product, to our Asian marketing partners.

Product margin for Genzyme General's Diagnostic Products increased 103% for the three months ended March 31, 2003, as compared to the same period of 2002. This was primarily due to a 17% increase in sales of Diagnostic Products for the three months ended March 31, 2003, as compared to the same period of 2002, and a 13% decrease in the cost of products sold for the three months ended March 31, 2003, as compared to the same period of 2002. The decrease in the cost of products sold is partially attributable to a charge of $2.9 million recorded in the three months ended March 31, 2002, for the closure of a Diagnostic Products manufacturing facility in San Carlos, California for which there is no comparable amount in the three months ended March 31, 2003.

We expect that in the future Genzyme General's product margin as a percentage of product revenue will trend slightly lower, primarily due to lower margins normally attributable to Renagel phosphate binder and a product mix shift as sales of Diagnostic Products continue to increase.

Genzyme Biosurgery

Genzyme Biosurgery sells or provides a broad range of healthcare products and services. As a result, Genzyme Biosurgery's gross margins may vary significantly depending on the market conditions of each product or service.

The 36% increase in product margin for the three months ended March 31, 2003 as compared to the same period of 2002 was primarily attributable to a $9.3 million increase in product revenue. The increase in product revenue was primarily due to an increase in sales of Synvisc viscosupplementation product due to increased utilization of the product within the existing customer base as well as the creation of new accounts, and an increase in sales of Sepra products due to increased market penetration.

Service Margin

Genzyme General

The 18% increase in Genzyme General's service margin for the three months ended March 31, 2003, as compared to the same period of 2002, was primarily due to:

•: increased sales of molecular genetics (DNA) testing services, primarily due to growth in the cystic fibrosis screening and diagnosis market;
•: increased sales of cancer testing services; and
•: continued growth in the prenatal screening market.

Service margin as a percentage of service revenue was consistent for the three month period ending March 31, 2003, as compared to the same period of 2002. This was primarily attributable to a 15% increase in service revenue for the three months ended March 31, 2003, which was partially offset by a 13% increase in the cost of services sold for the same period.

Genzyme Biosurgery

Service margin for services allocated to Genzyme Biosurgery increased 62% for the three months ended March 31, 2003, as compared to the same period of 2002, and service margin as a percentage of service revenue increased primarily due to a 45% increase in sales of Orthopaedics services. This increase is a result of the classification of $1.5 million of reimbursed expenses from partners as service revenue.

OPERATING EXPENSES

Selling, General and Administrative Expenses

Selling, general and administrative expenses increased $11.3 million, or 11%, to $114.2 million for the three months ended March 31, 2003, as compared to same period a year ago, primarily due to:

•: a $4.8 million increase in selling and marketing costs for Renagel phosphate binder;
•: a $5.4 million increase in selling, general and administrative costs for Therapeutics products, of which $3.6 million is attributable to an increase in expenditures related to our increased market penetration for Fabrazyme enzyme in Europe; and a net increase of $1.8 million attributable to other therapeutic initiatives;
•: the creation of a sales force and an increase in Genzyme Biosurgery's sales operations in France in 2003 as we began to sell Synvisc viscosupplementation product directly to customers rather than through a distributor effective January 1, 2003; and
•: the classification of $1.5 million of reimbursed expenses from partners as service revenues.

The increases in selling, general and administrative expenses for the three months ended March 31, 2003, as compared to the same period of 2002, were offset by a net decrease of approximately $1.3 million attributable to administrative activities that we do not specifically allocate to a particular segment of Genzyme General and an overall decrease in expenses relating to Genzyme Biosurgery's Cardiac Devices business primarily due to increased operating efficiencies and reductions in staffing in 2002.

Research and Development Expenses

Research and development expenses decreased $6.5 million, or 8%, to $75.6 million for the three months ended March 31, 2003, as compared to the same period of 2002, primarily due to a $9.9 million decrease in spending for Therapeutics research and development programs. This decrease was offset by:

•: a $1.3 million increase in the cost of post-marketing clinical development efforts for Renagel phosphate binder;
•: a $1.3 million increase in spending on Genzyme Biosurgery's Orthopaedics business product development programs, particularly other indications for Synvisc viscosupplementation product; and
•: a $1.1 million increase in the Cardiac Science business product development programs, particularly cardiac cell therapy as a result of clinical trials initiated during the three months ended March 31, 2003.

The $9.9 million decrease in spending for Therapeutics research and development programs resulted from $10.8 million of additional charges that were included in research and development expenses for the three months ended March 31, 2002, for which there were no comparable amounts during the same period of 2003. The $10.8 million consisted of:

•: $8.8 million to reflect bulk product purchases and contract cancellation charges resulting from cancelling our manufacturing contract for the clinical development of the CHO therapy licensed from Synpac; and
•: $2.0 million attributable to reductions in staffing at Genzyme General's facilities in New Jersey and Oklahoma that were acquired in connection with our acquisition of Novazyme.

Amortization of Intangibles

There was no significant change in amortization of intangibles expense for the three months ended March 31, 2003, as compared to the same period in 2002.

Purchase of In-Process Research and Development

Novazyme

In September 2001, in connection with our acquisition of Novazyme, we acquired a technology platform that we believe can be leveraged in the development of treatments for various LSDs. As of the acquisition date, the technology platform had not achieved technological feasibility and would require significant further development to complete. Accordingly, we allocated to IPR&D and charged to expense $86.8 million, representing the portion of the purchase price attributable to the technology platform. Genzyme General recorded this amount as a charge to expense in its combined statements of operations for the year ended December 31, 2001.

The platform technology is specific to LSDs and there is currently no alternative use for the technology in the event that it fails as a platform for enzyme replacement therapy for the treatment of LSDs. As of March 31, 2003, we estimate that it will take approximately six to eight years and an investment of approximately $100 million to $125 million to complete the development of, obtain approval for and commercialize the first product based on this technology platform.

GelTex

March 31, 2003, the technological feasibility of the projects had not yet been reached and no significant departures from the assumptions included in the valuation analysis had occurred.

Below is a brief description of the GelTex IPR&D projects, including an estimation of when management believes we may realize revenues from the sales of these products for their respective indications:

Program	Program Description or Indication		Development Status at March 31, 2003	Value at Acquisition Date		Estimated Cost to Complete at March 31, 2003		Year of Expected Product Launch
				(in millions)
Renagel phosphate binder	Next stage non-absorbed polymer phosphate binder for the treatment of hyperphosphatemia	•	Clinical studies scheduled for completion in 2004 and 2005	$	19.7	$	10.2	2005
Tolevamer toxin binder	C. difficile associated diarrhea	•	Phase 2 trial expected to be completed in 2003		37.4		48.0	2007
GT56-252 oral iron chelator	Iron overload disease	•	Phase 1 trial ongoing		15.7		34.7	2007
GT316-235 fat absorption inhibitor	Anti-obesity	•	Expected to file an IND in 2004		17.8		59.3	2010
Polymer	Oral mucositis	•	Expected to file an IND in 2004		17.8		37.7	2008
DENSPM	Psoriasis	•	Program cancelled during 2001; no further development planned		3.4		N/A	N/A
GT102-279	Second generation lipid-lowering compound	•	Program cancelled during 2001; no further development planned		6.2		N/A	N/A

				$	118.0	$	189.9

Substantial additional research and development will be required prior to any of our acquired IPR&D programs and technology platforms reaching technological feasibility. In addition, once research is completed, each product will need to complete a series of clinical trials and receive FDA or other regulatory approvals prior to commercialization. Our current estimates of the time and investment required to develop these products and technologies may change depending on the different applications that we may choose to pursue. We cannot give you assurances that these programs will ever reach feasibility or develop into products that can be marketed profitably. In addition, we cannot guarantee that we will be able to develop and commercialize products before our competitors develop and commercialize products for the same indications. If products based on our acquired IPR&D programs and technology platforms do not become commercially viable, our results of operations could be materially affected.

Biomatrix

In connection with our acquisition of Biomatrix, we allocated approximately $82.1 million to IPR&D, which Genzyme Biosurgery recorded as a charge to expense in its combined statements of operations for the year ended December 31, 2000. As of March 31, 2003, the technological feasibility of the Biomatrix IPR&D projects had not yet been reached and no significant departures from the assumptions included in the valuation analysis had occurred.

Below is a brief description of the Biomatrix IPR&D projects, including an estimation of when management believes we may realize revenues from the sales of these products in the respective application:

Program	Program Description or Indication		Development Status at March 31, 2003	Value at Acquisition Date		Estimated Cost to Complete at March 31, 2003		Year of Expected Product Launch
				(in millions)
Viscosupplementation	Use of elastoviscous solutions and viscoelastic gels in disease conditions to supplement tissues and body fluids, alleviating pain and restoring normal function	• • • •	Received conditional FDA approval for hip indication clinical trial in U.S. Preclinical activities in U.S. and clinical trial in Europe for knee indications Preclinical for other joints Product launched for hip indication in Europe in September 2002	$	33.8	$	22.3	2002 to 2008
Visco-augmentation and Visco-separation	Use of viscoelastic gels to provide scaffolding for tissue regeneration and to separate tissues and decrease formation of adhesions and excessive scars after surgery	• • •	Preclinical—gynecological and pelvic indications Clinical trials—pivotal safety and efficacy study on-going in U.S. for Hylaform biomaterials Phase 2—spine indications; program cancelled during 2002; no further development planned		48.3 N/A		4.2 N/A	2003 to 2006 N/A

				$	82.1	$	26.5

Except for our viscosupplementation product for the hip launched in Europe in 2002, substantial additional research and development will be required prior to any of our acquired IPR&D programs and technology platforms reaching technological feasibility. In addition, once research is completed, each product will need to complete a series of clinical trials and receive FDA or other regulatory approvals prior to commercialization. Our current estimates of the time and investment required to develop these products and technologies may change depending on the different applications that we may choose to pursue. We cannot give assurances that these programs will ever reach feasibility or develop into products that can be marketed profitably. In addition, we cannot guarantee that we will be able to develop and commercialize products before our competitors develop and commercialize products for the same indications. If products based on our acquired IPR&D programs and technology platforms do not become commercially viable, our results of operations could be materially affected.

OTHER INCOME AND EXPENSES

		Three Months Ended March 31,
		Three Months Ended March 31,						Increase/ (Decrease) % Change
		2003			2002			Increase/ (Decrease) % Change
		(Amounts in thousands, except percentage data)
Equity in net loss of unconsolidated affiliates		$	(4,194	)	$	(4,094	)	2	%
Gain on investments in equity securities			—			166		(100	)%
Other			750			(864	)	187	%
Investment income			11,614			13,437		(14	)%
Interest expense			(6,490	)		(6,806	)	(5	)%

	Total other income	$	1,680		$	1,839		(9	)%

Equity in Net Loss of Unconsolidated Affiliates

We record the results of the following joint ventures in equity in net loss of unconsolidated affiliates:

Joint Venture		Partner		Effective Date		Product/Indication
BioMarin/ Genzyme LLC		BioMarin Pharmaceutical Inc.		September 1998		Aldurazyme enzyme for the treatment of mucopolysaccharidosis-I
Diacrin/Genzyme LLC (1)		Diacrin, Inc.		October 1996		Products using porcine fetal cells for the treatment of Parkinson's and Huntington's diseases

(1): The joint venture is no longer actively developing these products.

The following table presents our equity in net loss of unconsolidated affiliates by entity for the periods presented:

		Three Months Ended March 31,
Joint Venture/Unconsolidated Affiliate		Three Months Ended March 31,						Increase/ (Decrease) % Change
Joint Venture/Unconsolidated Affiliate		2003			2002			Increase/ (Decrease) % Change
		(Amounts in thousands, except percentage data)
BioMarin/Genzyme LLC		$	(4,051	)	$	(2,842	)	43	%
Diacrin/Genzyme LLC			(143	)		(150	)	(5	)%
GTC			—			(1,102	)	(100	)%

	Total	$	(4,194	)	$	(4,094	)	2	%

We record in equity in net loss of unconsolidated affiliates our portion of the results of our joint ventures with BioMarin and Diacrin and, through May 2002, our portion of the losses of GTC.

Our equity in net loss of unconsolidated affiliates increased 2% to $4.2 million for the three months ended March 31, 2003, as compared to the same period of 2002. The increase was attributable to:

•: a $1.2 million increase in net losses from our joint venture with BioMarin, our partner for the development of Aldurazyme enzyme, primarily due to increased costs associated with the planned shift of efforts towards the manufacture and commercialization of Aldurazyme enzyme. We received U.S. marketing approval from the FDA for Aldurazyme enzyme on April 30, 2003. We expect European Commission action on the marketing application for Aldurazyme enzyme by the end of the second quarter of 2003 following the issuance of a positive opinion by the

Committee for Proprietary Medicinal Products, or CPMP, of the EMEA in February 2003. The opinion, while not binding upon the European Commission, is the final step before formal approval to market Aldurazyme enzyme in the fifteen countries of the European Union can be granted; and

•: a $1.1 million decrease in net losses in our equity position in GTC.

On April 4, 2002, GTC purchased approximately 2.8 million shares of GTC common stock held by us and allocated to Genzyme General for an aggregate consideration of $9.6 million. We received $4.8 million in cash and a promissory note for the remaining amount. The shares of GTC common stock sold were valued at $3.385 per share in this transaction, using the simple average of the high and low transaction prices quoted on the Nasdaq National Market on April 1, 2002. We have committed to a 24-month lock-up provision on the remaining 4.9 million shares of GTC common stock held by us and allocated to Genzyme General, which is approximately 18% of the shares of GTC common stock outstanding as of March 31, 2003. We accounted for our investment in GTC under the equity method of accounting until May 2002, at which point our ownership interest and board representation was reduced below 20% and we did not have any other factors of significant influence. Accordingly, we ceased to have significant influence over GTC and we began accounting for our investment in GTC under the cost method of accounting in June 2002. Equity in net loss of unconsolidated affiliates in our consolidated statements of operations and the combined statements of operations of Genzyme General for the three months ended March 31, 2002 includes charges of $1.1 million representing our portion of the losses of GTC.

In January 2002, we formed Peptimmune as our wholly-owned subsidiary, by contributing $5.0 million of cash and $0.3 million of other assets allocated to Genzyme General to Peptimmune in exchange for 5.5 million shares of Peptimmune's Series A voting preferred stock and 100 shares of Peptimmune common stock. We allocated our investment in Peptimmune to Genzyme General. We consolidated the results of Peptimmune through February 2003 because during that period we owned 100% of the outstanding stock of Peptimmune. In March 2003, our investment in Peptimmune decreased to approximately 12% as a result of the sale by Peptimmune of shares of its Series B voting preferred stock to third party investors. In accordance with our policy pertaining to affiliate sales of stock, we recorded a $2.9 million net gain ($4.5 million pre-tax) due to the issuance by Peptimmune of shares of its Series B voting preferred stock, which was recorded as an increase to our investment in Peptimmune in other noncurrent assets and an increase to other comprehensive income in stockholders' equity in our consolidated balance sheet as of March 31, 2003. Although our ownership interest in Peptimmune has declined below 20%, certain factors exist that cause us to continue to have significant influence over Peptimmune. The chairman, president and chief executive officer of Peptimmune is a member of our board of directors, one of our corporate officers is a consultant to Peptimmune and we have several service agreements with Peptimmune. Accordingly, in March 2003, we began accounting for our investment in Peptimmune under the equity method of accounting.

Gain on Investments in Equity Securities

We did not record any significant realized gains or losses related to our investments in equity securities for the three months ended March 31, 2003 and 2002.

and, as a result, the remaining shares of GTC common stock that we hold will qualify as marketable securities under SFAS No. 115 and be carried on our consolidated balance sheets and the combined balance sheets of Genzyme General at fair value.

At March 31, 2003, our stockholders' equity includes $6.3 million of unrealized gains and $8.0 million of unrealized losses related to our other investments in equity securities, all of which are allocated to Genzyme General. We believe the losses related to our other investments in equity securities are temporary. We will record impairment charges related to the investments for which we have recorded unrealized losses at March 31, 2003 if the stocks do not recover within the next three to six months, all of which will be allocated to Genzyme General.

Other

We periodically enter foreign currency forward contracts, all of which have durations of less than three months. These contracts have not been designated as hedges and, accordingly, unrealized gains or losses on these contracts are reported in current earnings. The notional settlement value of foreign currency forward contracts outstanding as of March 31, 2003 is $50.6 million. At both March 31, 2003 and 2002, these contracts had a fair value of $0.2 million, representing an unrealized loss.

For the three months ended March 31, 2003, we also recorded in other in our consolidated statements of operations and the combined statements of operations of Genzyme General an unrealized gain of $0.1 million to reflect the change in value of our warrants to purchase shares of GTC common stock from January 1, 2003 to March 31, 2003, as compared to an unrealized loss of $(1.2) million for the same period of 2002.

Investment Income

Our investment income decreased 14% for the three months ended March 31, 2003, as compared to the same period of 2002, primarily due to a decrease in interest rates despite higher average cash balances.

Interest Expense

Our interest expense decreased 5% for the three months ended March 31, 2003, as compared to the same period of 2002, primarily due to a slight decline in debt balances outstanding resulting from the repayment, in 2002, of notes payable, aggregating $7.0 million, assumed in connection with our acquisitions of Novazyme in September 2001 and GelTex in December 2000.

Tax Provision

	Three Months Ended March 31,
	Three Months Ended March 31,						Increase/ (Decrease) % Change
	2003			2002			Increase/ (Decrease) % Change
	(Amounts in thousands, except percentage data)
Provision for income taxes	$	(18,998	)	$	(3,138	)	505	%
Effective tax rate		30	%		32	%

Our tax rates for all periods vary from the U.S. statutory tax rate as a result of its:

•: provision for state income taxes;
•: tax benefits from export sales; and
•: use of tax credits.

The decrease in our effective tax rate for the three months ended March 31, 2003, as compared to the same period of 2002 is primarily due to increased benefits from orphan drug credits.

CUMULATIVE EFFECT OF CHANGE IN ACCOUNTING FOR GOODWILL

On January 1, 2002, we adopted SFAS No. 142, which requires that ratable amortization of goodwill and certain intangible assets be replaced with periodic tests of goodwill's impairment and that other intangible assets be amortized over their useful lives unless these lives are determined to be indefinite. SFAS No. 142 requires a transitional impairment test to compare the fair value of a reporting unit with the carrying amount of the goodwill.

In November 2001, we sold our Snowden-Pencer line of surgical instruments. Our subsequent test of the remaining long-lived assets related to the remaining products of our surgical instruments and medical devices business line, which make up the majority of Genzyme Biosurgery's cardiothoracic devices reporting unit, under SFAS No. 121, did not indicate an impairment based on the undiscounted cash flows of the business. However, the impairment analysis indicated that the goodwill allocated to Genzyme Biosurgery's cardiothoracic devices reporting unit would be impaired if the analysis was done using discounted cash flows, as required by SFAS No. 142. Therefore, upon adoption of SFAS No. 142, Genzyme Biosurgery tested the goodwill of the cardiothoracic reporting unit in accordance with the transitional provisions of that standard, using the present value of expected future cash flows to estimate the fair value of this reporting unit. Genzyme Biosurgery recorded an impairment charge of $98.3 million, which was reflected as a cumulative effect of a change in accounting for goodwill in our consolidated statements of operations and the combined statements of operations for Genzyme Biosurgery for the three months ended March 31, 2002.

GENZYME GENERAL
A Division of Genzyme Corporation

The following discussion summarizes the key factors our management believes necessary for an understanding of Genzyme General's financial statements. When reviewing this discussion, you should keep in mind the substantial risks and uncertainties that characterize our business. In particular, we encourage you to review the risks and uncertainties described under "Factors Affecting Future Operating Results" in Exhibit 99.2 to our 2002 Form 10-K. These risks and uncertainties could cause our actual results to differ materially from those forecast in forward-looking statements or implied by past results and trends. Forward-looking statements are statements that attempt to project or anticipate future developments in our business; we encourage you to review the examples of forward-looking statements under "Note Regarding Forward-Looking Statements." These statements, like all statements in this report, speak only as of the date of this report (unless another date is indicated), and we undertake no obligation to update or revise the statements in light of future developments.

CRITICAL ACCOUNTING POLICIES AND SIGNIFICANT ESTIMATES

The critical accounting policies and significant estimates for Genzyme General are set forth under the heading "Management's Discussion and Analysis of Genzyme General's Financial Condition and Results of Operations—Critical Accounting Policies and Significant Estimates" in Exhibit 13.2 to our 2002 Form 10-K. There have been no changes to these policies and no significant changes to these estimates since December 31, 2002.

REVENUES

The components of Genzyme General's total revenues are described in the following table:

		Three Months Ended March 31,
		Three Months Ended March 31,				Increase/ (Decrease) % Change
		2003		2002		Increase/ (Decrease) % Change
		(Amounts in thousands, except percentage data)
Product revenue		$	289,039	$	218,463	32	%
Service revenue			24,455		21,175	15	%

	Total product and service revenue		313,494		239,638	31	%
Research and development revenue			551		2,509	(78	)%

	Total revenues	$	314,045	$	242,147	30	%

Product and Service Revenue

The following table sets forth Genzyme General's product and service revenues on a segment basis:

				Three Months Ended March 31,
				Three Months Ended March 31,				Increase/ (Decrease) % Change
				2003		2002		Increase/ (Decrease) % Change
				(Amounts in thousands, except percentage data)
Product revenue:
	Therapeutics:
		Cerezyme enzyme		$	167,187	$	148,066	13	%
		Other therapeutic products			30,024		11,445	162	%

			Total Therapeutics		197,211		159,511	24	%
	Renal				58,766		29,532	99	%
	Diagnostic Products				23,196		19,838	17	%
	Other				9,866		9,582	3	%

			Total product revenue		289,039		218,463	32	%
Service revenue:
	Other				24,455		21,175	15	%

			Total product and service revenue	$	313,494	$	239,638	31	%

Therapeutics

Genzyme General's increase in Therapeutics product revenue for the three months ended March 31, 2003, as compared to the same period of 2002, was primarily due to continued growth in sales of Cerezyme enzyme for the treatment of Type 1 Gaucher disease and increased sales of other therapeutic products. Other therapeutic products revenue consists primarily of:

•: sales of Thyrogen hormone, which is an adjunctive diagnostic agent used in the follow-up of patients with well-differentiated thyroid cancer;
•: sales of Fabrazyme enzyme, which is a recombinant form of the human enzyme alpha-galactosidase used for the treatment of Fabry disease; and
•: bulk sales of and royalties earned on sales of WelChol bile acid binder, which is an adjunctive therapy for the reduction of elevated LDL cholesterol in patients with primary hypercholesterolemia.

The growth in sales of Cerezyme enzyme for the three months ended March 31, 2003, as compared to the same period of 2002, was attributable to Genzyme General's continued identification of new Gaucher disease patients worldwide, particularly in Europe, resulting from a significant investment in our global sales and marketing infrastructure. The growth in European sales of Cerezyme enzyme for the period was positively impacted by the weakened U.S. Dollar against the Euro. During the three months ended March 31, 2003, as compared to the same period of 2002, the U.S. Dollar weakened against the Euro on average by approximately 22%, which positively impacted sales of Cerezyme enzyme by $10.5 million. Sales of Cerezyme enzyme were approximately 58% of Genzyme General's total product revenue for the three months ended March 31, 2003, as compared to 68% for the same period of 2002.

Genzyme General's results of operations are highly dependent on sales of Cerezyme enzyme and a reduction in revenue from sales of this product would adversely affect its results of operations. Revenue

from Cerezyme enzyme would be impacted negatively if competitors developed alternative treatments for Gaucher disease and the alternative products gained commercial acceptance. Although orphan drug status for Cerezyme enzyme, which provided us with exclusive marketing rights for Cerezyme enzyme in the U.S., expired in May 2001, we continue to have patents protecting our method of manufacturing Cerezyme enzyme until 2010 and the composition of Cerezyme enzyme as made by that process until 2013. The expiration of market exclusivity and orphan drug status will likely subject Cerezyme enzyme to increased competition, which may decrease the amount of revenue we receive from this product or the growth of that revenue.

Genzyme General is aware of companies that have initiated efforts to develop competitive products, and other companies may do so in the future. For example, OGS is developing Zavesca, a small molecule drug candidate for the treatment of Type 1 Gaucher disease. Zavesca has been granted orphan drug status in the U.S. for treatment of Type 1 Gaucher and Fabry diseases, and has been designated as an orphan medicinal product in the European Union for the treatment of Type 1 Gaucher disease. In July 2002, the FDA issued a "non approvable" letter to OGS in response to its NDA for Zavesca; in November 2002, however, the agency agreed to examine additional data in support of that NDA. OGS filed an amendment to its NDA for Zavesca with additional data in March 2003. Also in November 2002, the European Commission approved OGS's MAA for Zavesca as an oral therapy for use in patients with mild to moderate Type 1 Gaucher disease for whom enzyme replacement therapy is unsuitable. OGS will be required to submit follow-up safety data on the product as a condition of such approval. In January 2003, a licensee of OGS submitted an application for approval of Zavesca with the Israeli Ministry of Health. To date, virtually all Gaucher disease patients who have received enzyme therapy have experienced strong clinical benefit with few side effects so we do not expect the competition from Zavesca to have a significant impact on our sales of Cerezyme enzyme.

Other therapeutic products revenue consists primarily of sales of Thyrogen hormone, Fabrazyme enzyme and bulk sales of and royalties earned on sales of WelChol bile acid binder. The increase in other therapeutic products revenue for the three months ended March 31, 2003, as compared to the same period of 2002, is attributable to:

•: a 61% increase in sales of Thyrogen hormone to $9.7 million primarily due to increased market penetration, particularly in Europe, where sales increased 126% to $4.1 million;
•: a 193% increase in sales of Fabrazyme enzyme in Europe to $11.6 million partially due to Genzyme General's introduction of the product in several new markets in Europe and its continued program to educate European physicians about Fabry disease and Fabrazyme enzyme; and
•: a 462% increase in royalties earned on sales of WelChol bile acid binder to $8.1 million for the three months ended March 31, 2003 as compared to the same period of 2002. These increases were the result of sales to our U.S. marketing partner, Sankyo Pharma, Inc., which experienced continued market growth of the product in the U.S. during the first quarter of 2003. In October 2002, Merck/Schering-Plough Pharmaceuticals received marketing approval in Germany and FDA approval in the U.S. for its competitive product, ezetimibe, for use alone and with marketed statins for the treatment of elevated cholesterol levels as a second-line therapy. The introduction of this product in the U.S. may adversely affect the future growth of bulk sales of and royalties earned on sales of our Welchol bile acid binder.

Renal

In September 2002, we created the Renal reporting segment consisting primarily of amounts attributable to the manufacture and sale of Renagel phosphate binder. Previously, amounts attributable to the manufacture and sale of Renagel phosphate binder had been included as a component of

Genzyme General's Therapeutics reporting segment. We have reclassified Genzyme General's 2002 disclosures to conform to its 2003 presentation. Genzyme General expects sales of Renagel phosphate binder to increase, driven primarily by the continued adoption of the product by nephrologists worldwide. The increase in sales of Renagel phosphate binder will be dependent on several factors, including:

•: acceptance by the medical community of Renagel phosphate binder as the preferred treatment for elevated serum phosphorus levels in end-stage renal disease patients on hemodialysis;
•: our ability to effectively manage wholesaler inventories and the levels of compliance with the inventory management programs we implemented with our wholesalers in 2002;
•: our ability to optimize dosing and improve patient compliance with dosing of Renagel phosphate binder;
•: the availability of reimbursement from third party payors and the extent of coverage;
•: our ability to manufacture sufficient quantities of product to meet demand and to do so at a reasonable price;
•: the results of additional clinical trials for additional indications and expanded labeling;
•: the availability of competing treatments;
•: the efficiencies of our sales force; and
•: the content and timing of our submissions to and decisions by regulatory authorities.

•: continued strong end-user demand for the product;
•: reductions in domestic wholesaler inventories during 2002 that negatively impacted revenues during that year; and
•: approximately $3 million in sales of bulk sevelamer, the raw material used to formulate Renagel phosphate binder, to Chugai for which there were no comparable amounts in 2002. Chugai, together with its partner, Kirin Pharmaceutical Co. Ltd., has the right to develop and market Renagel phosphate binder in Japan, China and other Pacific Rim countries, and Chugai plans to launch commercial sales in Japan in the second quarter of 2003. We will continue supplying bulk sevelamer to Chugai and will receive royalties on net sales of the finished product.

•: the expansion of the worldwide Renagel phosphate binder sales force;
•: favorable promotion of published clinical data that has increased international adoption of the product, particularly in Europe, where units sales increased 69%; and
•: a 22% increase in the average exchange rate of the Euro, which positively impacted sales of Renagel phosphate binder by $2.2 million.

During the three months ended March 31, 2003, we obtained reimbursement approval for the 800 mg tablet formulation of Renagel phosphate binder in France, the last major European market where

this form of the product had previously been unavailable. In addition, in March 2003, we began shipping Renagel phosphate binder tablets to the European market from our new cGMP manufacturing facility in Waterford, Ireland, upon receiving approval from the EMEA to commence production of Renagel phosphate binder at the plant. We anticipate that the FDA will approve production of Renagel phosphate binder at the plant during 2003. Sales of Renagel phosphate binder were approximately 20% of Genzyme General's total product revenue for the three months ended March 31, 2003 as compared to 14% for the same period of 2002.

Diagnostic Products

Diagnostic Products product revenue increased 17% for the three months ended March 31, 2003 as compared to the same period of 2002. The increase was primarily attributable to:

•: an 11% increase in the combined sales of infectious disease testing products, HDL and LDL cholesterol testing products and royalties on product sales by Techne's biotechnology group to $15.9 million; and
•: a 32% increase in sales of point of care rapid diagnostic tests for pregnancy and infectious diseases to $7.3 million.

Other Product and Service Revenue

Service revenue increased 15% for the three months ended March 31, 2003 as compared to the same period of 2002. The increase was primarily attributable to:

•: increased sales of molecular genetics (DNA) testing services, primarily due to growth in the cystic fibrosis screening and diagnosis market;
•: increased sales of cancer testing services; and
•: continued growth in the prenatal screening market.

International Product and Service Revenue

A substantial portion of Genzyme General's revenue was generated outside of the U.S. Most of these revenues were attributable to sales of Cerezyme enzyme. The following table provides information regarding the change in international product and service revenue as a percentage of total product and service revenue during the periods presented:

		Three Months Ended March 31,
		Three Months Ended March 31,						Increase/ (Decrease) % Change
		2003			2002			Increase/ (Decrease) % Change
		(Amounts in thousands, except percentage data)
International product and service revenue.		$	140,609		$	103,514		36	%
	% of total product and service revenue		45	%		43	%

International sales of Cerezyme enzyme increased 22% to $94.9 million for the three months ended March 31, 2003, as compared to $77.8 million in the same period of 2002, primarily due to:

•: a 7% increase in international unit sales of Cerezyme enzyme; and

•: a 22% increase in the average exchange rate of the Euro, which positively impacted sales of Cerezyme enzyme by $10.5 million.

International sales of Renagel phosphate binder increased 103% to $16.9 million for the three months ended March 31, 2003, as compared to $8.4 million for the same period of 2002, primarily due to:

•: the expansion of the worldwide Renagel phosphate binder sales force;
•: the introduction of Renagel phosphate binder into several new international markets in 2002;
•: favorable promotion of published clinical data that has increased international adoption of the product, particularly in Europe, where units sales increased 69%; and
•: a 22% increase in the average exchange rate of the Euro, which positively impacted sales of Renagel phosphate binder by $2.2 million.

International sales of Fabrazyme enzyme increased 198% to $11.8 million for the three months ended March 31, 2003, as compared to $4.0 million for the same period of 2002, primarily due to:

•: the introduction of Fabrazyme enzyme into several new markets in Europe in 2002;
•: our continued program to educate European physicians about Fabry disease and Fabrazyme enzyme; and
•: a 22% increase in the average exchange rate of the Euro, which positively impacted sales of Fabrazyme enzyme by $1.8 million.

Research and Development Revenue

The following table sets forth our research and development revenue on a segment basis:

		Three Months Ended March 31,
		Three Months Ended March 31,				Increase/ (Decrease) % Change
		2003		2002		Increase/ (Decrease) % Change
		(Amounts in thousands, except percentage data)
Therapeutics		$	—	$	1,796	(100	)%
Other			43		31	39	%
Eliminations/Adjustments			508		682	(26	)%

	Total research and development revenues	$	551	$	2,509	(78	)%

MARGINS

		Three Months Ended March 31,
		Three Months Ended March 31,						Increase/ (Decrease) % Change
		2003			2002			Increase/ (Decrease) % Change
		(Amounts in thousands, except percentage data)
Product margin		$	219,463		$	170,864		28	%
	% of product revenue		76	%		78	%
Service margin			10,991			9,309		18	%
	% of service revenue		45	%		44	%
Total gross margin		$	230,454		$	180,173		28	%
	% of total product and service revenue		74	%		75	%

Product Margin

Product margin for the Therapeutics reporting segment increased 20% for the three months ended March 31, 2003, as compared to the same period of 2002. This was due to a 24% increase in sales of Therapeutics products primarily attributable to increased sales of Cerezyme enzyme, Thyrogen hormone and Fabrazyme enzyme for the three months ended March 31, 2003, as compared to the same period of 2002. The increase in product margin for the three months ended March 31, 2003 was offset, in part, by the write off of $2.3 million of Cerezyme enzyme finished goods due to production issues, for which there is no similar write off in the same period of 2002.

Product margin for the Renal reporting segment increased 94% for the three months ended March 31, 2003 as compared to the same period of 2002. This was primarily due to an increase in sales of Renagel phosphate binder for the three months ended March 31, 2003, as compared to the same period in 2002, offset by an increase in the rebate reserve for the product corresponding to an increase in our estimates of the percentage of patients being reimbursed by government programs. In addition, product margin for the Renal reporting segment is impacted by sales of bulk sevelamer, a lower margin product, to our Asian marketing partners.

Product margin for Diagnostic Products increased 103% for the three months ended March 31, 2003, as compared to the same period of 2002. This was primarily due to a 17% increase in sales of Diagnostic Products for the three months ended March 31, 2003, as compared to the same period of 2002, and a 13% decrease in the cost of products sold for the three months ended March 31, 2003, as compared to the same period of 2002. The decrease in the cost of products sold is partially attributable to a charge of $2.9 million recorded in the three months ended March 31, 2002, for the closure of a Diagnostic Products manufacturing facility in San Carlos, California for which there is no comparable amount in the three months ended March 31, 2003.

Service Margin

The 18% increase in service margin for the three month period ended March 31, 2003, as compared to the same period of 2002, was primarily due to:

•: increased sales of molecular genetics (DNA) testing services, primarily due to growth in the cystic fibrosis screening and diagnosis market;
•: increased sales of cancer testing services; and
•: continued growth in the prenatal screening market.

Service margin as a percentage of service revenue increased slightly for the three month period ending March 31, 2003 as compared to the same period of 2002. This was primarily attributable to a 15% increase in service revenue for the three months ended March 31, 2003, which was partially offset by a 13% increase in the cost of services sold for the same period.

OPERATING EXPENSES

Selling, General and Administrative Expenses

Selling, general and administrative expenses increased $8.9 million or 12% to $85.2 million for the three months ended March 31, 2003, as compared to the same period of 2002, primarily due to:

•: a $4.8 million increase in selling and marketing costs for Renagel phosphate binder; and
•: a $5.4 million increase in selling, general and administrative costs for Therapeutics products, of which $3.6 million is attributable to an increase in expenditures related to our increased market penetration for Fabrazyme enzyme in Europe and a net increase of $1.8 million which is attributable to other Therapeutics initiatives.

Research and Development Expenses

Research and development expenses decreased $7.5 million or 12% to $56.3 million for the three months ended March 31, 2003, as compared to the same period of 2002, primarily due to a $9.9 million decrease in spending for Therapeutics research and development programs offset by a $1.3 million increase in the cost of post-marketing clinical development efforts for Renagel phosphate binder.

•: $8.8 million to reflect bulk product purchases and contract cancellation charges resulting from cancelling our manufacturing contract for the clinical development of the CHO therapy licensed from Synpac; and
•: $2.0 million attributable to reductions in staffing at Genzyme General's facilities in New Jersey and Oklahoma that were acquired in connection with our acquisition of Novazyme.

Amortization of Intangibles

Amortization of intangibles expense remained constant at $9.7 million for the three months ended March 31, 2003, as compared to the same period of 2002.

Purchase of In-Process Research and Development

Novazyme

The platform technology is specific to LSDs and there is currently no alternative use for the technology in the event that it fails as a platform for enzyme replacement therapy for the treatment of LSDs. As of March 31, 2002, we estimate that it will take approximately six to eight years and an investment of approximately $100 million to $125 million to complete the development of, obtain approval for and commercialize the first product based on this technology platform.

GelTex

In December 2000, in connection with the acquisition of GelTex, we allocated approximately $118.0 million of the purchase price to IPR&D, which Genzyme General recorded as a charge to expense in its combined statement of operations for the year ended December 31, 2000. As of March 31, 2003, the technological feasibility of the projects had not yet been reached and no significant departures from the assumptions included in the valuation analysis had occurred.

Below is a brief description of the GelTex IPR&D projects, including an estimation of when management believes Genzyme General may realize revenues from the sales of these products for their respective indications:

Program	Program Description or Indication		Development Status at March 31, 2003	Value at Acquisition Date		Estimated Cost to Complete at March 31, 2003		Year of Expected Product Launch
				(in millions)
Renagel phosphate binder	Next stage non-absorbed polymer phosphate binder for the treatment of hyperphospatemia	•	Clinical studies scheduled for completion in 2004 and 2005	$	19.7	$	10.2	2005
Tolevamer toxin binder	C. difficile associated diarrhea	•	Phase 2 trial expected to be completed in 2003		37.4		48.0	2007
GT56-252 oral iron chelator	Iron overload disease	•	Phase 1/2 trial ongoing		15.7		34.7	2007
GT316-235 fat absorption inhibitor	Anti-obesity	•	Expected to file an IND in 2004		17.8		59.3	2010
Polymer	Oral mucositis	•	Expected to file an IND in 2004		17.8		37.7	2008
DENSPM	Psoriasis	•	Program cancelled during 2001; no further development planned		3.4		N/A	N/A
GT102-279	Second generation lipid-lowering compound	•	Program cancelled during 2001; no further development planned		6.2		N/A	N/A

				$	118.0	$	189.9

OTHER INCOME AND EXPENSES

		Three Months Ended March 31,
		Three Months Ended March 31,						Increase/ (Decrease) % Change
		2003			2002			Increase/ (Decrease) % Change
		(Amounts in thousands, except percentage data)
Equity in net loss of unconsolidated affiliates		$	(4,194	)	$	(4,094	)	2	%
Gain on investments in equity securities			—			166		(100	)%
Other			780			(897	)	(187	)%
Investment income			11,281			12,952		(13	)%
Interest expense			(4,277	)		(4,541	)	(6	)%

	Total other income (expenses)	$	3,590		$	3,586		0	%

Equity in Net Loss of Unconsolidated Affiliates

The following table presents our equity in net loss of unconsolidated affiliates by entity for the periods presented:

		Three Months Ended March 31,
Joint Venture/Unconsolidated Affiliate		Three Months Ended March 31,						Increase/ (Decrease) % Change
Joint Venture/Unconsolidated Affiliate		2003			2002			Increase/ (Decrease) % Change
		(Amounts in thousands, except percentage data)
BioMarin/Genzyme LLC		$	(4,051	)	$	(2,842	)	43	%
Diacrin/Genzyme LLC			(143	)		(150	)	(5	)%
GTC			—			(1,102	)	(100	)%

	Total	$	(4,194	)	$	(4,094	)	2	%

Genzyme General records in equity in net loss of unconsolidated affiliates its portion of the results of our joint ventures with BioMarin and Diacrin and, through May 2002, our portion of the losses of GTC.

Genzyme General's equity in net loss of unconsolidated affiliates increased 2% to $4.2 million for the three months ended March 31, 2003 as compared to the same period of 2002. The increase was attributable to:

•: a $1.2 million increase in net losses from our joint venture with BioMarin, our partner for the development of Aldurazyme enzyme, primarily due to increased costs associated with the planned shift of efforts towards the manufacture and commercialization of Aldurazyme enzyme. We received U.S. marketing approval from the FDA for Aldurazyme enzyme on April 30, 2003. We expect European Commission action on the marketing application for Aldurazyme enzyme by the end of the second quarter of 2003 following the issuance of a positive opinion by the CPMP of the EMEA in February 2003. The opinion, while not binding upon the European Commission, is the final step before formal approval to market Aldurazyme enzyme in the fifteen countries of the European Union can be granted; and
•: a $1.1 million decrease in net losses in our equity position in GTC.

a 24-month lock-up provision on the remaining 4.9 million shares of GTC common stock held by us and allocated to Genzyme General, which is approximately 18% of the shares of GTC common stock outstanding as of March 31, 2003. We accounted for our investment in GTC under the equity method of accounting until May 2002, at which point our ownership interest and board representation was reduced below 20% and we did not have any other factors of significant influence. Accordingly, we ceased to have significant influence over GTC and we began accounting for our investment in GTC under the cost method of accounting in June 2002. Equity in net loss of unconsolidated affiliates in our consolidated statements of operations and the combined statements of operations of Genzyme General for the three months ended March 31, 2002 includes charges of $1.1 million representing our portion of the losses of GTC.

In January 2002, we formed Peptimmune as our wholly-owned subsidiary, by contributing $5.0 million of cash and $0.3 million of other assets allocated to Genzyme General to Peptimmune in exchange for 5.5 million shares of Peptimmune's Series A voting preferred stock and 100 shares of Peptimmune common stock. We allocated our investment in Peptimmune to Genzyme General, which consolidated the results of Peptimmune through February 2003 because during that period we owned 100% of the outstanding stock of Peptimmune. In March 2003, our investment in Peptimmune decreased to approximately 12% as a result of the sale by Peptimmune of shares of its Series B voting preferred stock to third party investors. In accordance with our policy pertaining to affiliate sales of stock, we recorded a $2.9 million net gain ($4.5 million pre-tax) due to the issuance by Peptimmune of shares of its Series B voting preferred stock, which was recorded as an increase to Genzyme General's investment in Peptimmune in other noncurrent assets and an increase to other comprehensive income in division equity in Genzyme General's combined balance sheet as of March 31, 2003. Although our ownership interest in Peptimmune has declined below 20%, certain factors exist that cause us to continue to have significant influence over Peptimmune. The chairman, president and chief executive officer of Peptimmune is a member of our board of directors, one of our corporate officers is a consultant to Peptimmune and we have several service agreements with Peptimmune. Accordingly, in March 2003, Genzyme General began accounting for our investment in Peptimmune under the equity method of accounting.

Gain on Investment in Equity Securities

Genzyme General did not record any significant realized gains or losses related to its investments in equity securities for the three months ended March 31, 2003 and 2002.

Because we are within the first 12 months of the 24-month lock-up provision described above, the remaining 4.9 million shares of GTC common stock held by us do not qualify as marketable securities under SFAS No. 115, "Accounting for Certain Investments in Debt and Equity Securities." As a result, we carry the investment on our consolidated balance sheets and the combined balance sheets of Genzyme General at cost, subject to review for impairment. Based on the market price of GTC common stock at March 31, 2003, our remaining investment would have an unrealized gain of $1.7 million. Effective April 4, 2003, we will begin the last 12 months of the 24-month lock-up provision and, as a result, the remaining shares of GTC common stock that we hold will qualify as marketable securities under SFAS No. 115 and be carried on our consolidated balance sheets and the combined balance sheets of Genzyme General at fair value.

At March 31, 2003, Genzyme General's division equity includes $6.3 million of unrealized gains and $8.0 million of unrealized losses related to our other investments in equity securities, all of which are allocated to Genzyme General. We believe the losses related to our other investments in equity securities are temporary. Genzyme General will record impairment charges related to the investments for which it has recorded unrealized losses at March 31, 2003 if the stocks do not recover within the next three to six months, all of which will be allocated to Genzyme General.

Other

Genzyme General periodically enters foreign currency forward contracts, all of which have durations of less than three months. These contracts have not been designated as hedges and, accordingly, unrealized gains or losses on these contracts are reported in current earnings. The notional settlement value of foreign currency forward contracts outstanding as of March 31, 2003 is $50.6 million. At both March 31, 2003 and 2002, these contracts had a fair value of $0.2 million, representing an unrealized loss.

For the three months ended March 31, 2003, Genzyme General also recorded in other in our consolidated statements of operations and the combined statements of operations of Genzyme General an unrealized gain of $0.1 million to reflect the change in value of our warrants to purchase shares of GTC common stock from January 1, 2003 to March 31, 2003 as compared to an unrealized loss of $(1.2) million for the same period of 2002.

Investment Income

Genzyme General's investment income decreased 13% for the three months ended March 31, 2003, as compared to the same period of 2002, primarily due to a decrease in interest rates despite higher average cash balances.

Interest Expense

Genzyme General's interest expense decreased 6% for the three months ended March 31, 2003, as compared to the same period of 2002, primarily due to a slight decline in debt balances outstanding resulting from the repayment, in 2002, of notes payable, aggregating $7.0 million, assumed in connection with our acquisitions of Novazyme in September 2001 and GelTex in December 2000.

Tax Provision

	Three Months Ended March 31,
	Three Months Ended March 31,						Increase/ (Decrease) % Change
	2003			2002			Increase/ (Decrease) % Change
	(Amounts in thousands, except percentage data)
Provision for income taxes	$	(25,491	)	$	(12,015	)	112	%
Effective tax rate		31	%		33	%

Genzyme General's tax rates for all periods vary from the U.S. statutory tax rate as a result of its:

•: provision for state income taxes;
•: tax benefits from export sales; and
•: use of tax credits.

The decrease in our effective tax rate for the three months ended March 31, 2003, as compared to the same period of 2002, is primarily due to increased benefits from orphan drug credits.

GENZYME BIOSURGERY
A Division of Genzyme Corporation

The following discussion summarizes the key factors our management believes necessary for an understanding of Genzyme Biosurgery's financial statements. When reviewing this discussion, you should keep in mind the substantial risks and uncertainties that characterize our business. In particular, we encourage you to review the risks and uncertainties described under "Factors Affecting Future Operating Results" in Exhibit 99.2 to our 2002 Form 10-K. These risks and uncertainties could cause our actual results to differ materially from those forecast in forward-looking statements or implied by past results and trends. Forward-looking statements are statements that attempt to project or anticipate future developments in our business; we encourage you to review the examples of forward-looking statements under "Note Regarding Forward-Looking Statements." These statements, like all statements in this report, speak only as of the date of this report (unless another date is indicated), and we undertake no obligation to update or revise the statements in light of future developments.

CRITICAL ACCOUNTING POLICIES AND SIGNIFICANT ESTIMATES

The critical accounting policies and significant estimates for Genzyme Biosurgery are set forth under the heading "Management's Discussion and Analysis of Genzyme Biosurgery's Financial Condition and Results of Operations—Critical Accounting Policies and Significant Estimates" in Exhibit 13.3 to our 2002 Form 10-K. There have been no changes to these policies and no significant changes to these estimates since December 31, 2002.

REVENUES

The components of Genzyme Biosurgery's total revenues are described in the following table:

			Three Months Ended March 31,
			Three Months Ended March 31,				Increase/ (Decrease) % Change
			2003		2002		Increase/ (Decrease) % Change
			(Amounts in thousands, except percentage data)
Product revenue:
	Orthopaedics		$	26,354	$	19,998	32	%
	Biosurgical Specialties			12,104		9,990	21	%
	Cardiac Science			12		—	N/A
	Cardiac Devices			18,980		18,175	4	%

		Total product revenue		57,450		48,163	19	%

Service revenue:
	Orthopaedics			6,067		4,177	45	%
	Biosurgical Specialties			973		1,031	(6	)%
	Cardiac Science			3		—	N/A

		Total service revenue		7,043		5,208	35	%

Research and development revenue:
	Orthopaedics			430		—	N/A
	Biosurgical Specialties			686		—	N/A
	Cardiac Science			17		—	N/A

		Total research and development revenue		1,133		—	N/A

		Total revenues	$	65,626	$	53,371	23	%

Product Revenue

In January 2003, Genzyme Biosurgery reallocated two suture product lines from its Biosurgical Specialties reporting segment to its Cardiac Devices reporting segment, so that all suture product lines are reflected as components of its Cardiac Devices reporting segment. In addition, Genzyme Biosurgery reallocated its cardiovascular Sepra products from its Cardiac Devices reporting segment to its Biosurgical Specialties reporting segment. Genzyme Biosurgery has reclassified its 2002 disclosures to conform to its 2003 presentation.

Orthopaedics product revenue increased 32% to $26.4 million for the three months ended March 31, 2003 as compared to the same period of 2002 primarily due to an increase in sales of Synvisc viscosupplementation product. Synvisc viscosupplementation product sales increased primarily due to increased utilization of the product within the existing customer base as well as the creation of new accounts. We believe that a potentially significant competitor is currently seeking FDA approval for a viscosupplementation product for possible U.S. launch during the second half of 2003 that could have an adverse affect on future sales of Synvisc viscosupplementation product.

In January 2003, as a result of a change in how Genzyme Biosurgery reviews its business, the activities of its former Cardiothoracic reporting segment were reallocated into two separate reporting segments called Cardiac Science and Cardiac Devices. Genzyme Biosurgery has reclassified 2002 disclosures to conform to our 2003 presentation. Cardiac Devices products include fluid management (chest drainage) systems, surgical closures, biomaterials, and instruments for conventional and minimally invasive cardiac surgery. Cardiac Devices product revenue increased 4% to $19.0 million for the three months ended March 31, 2003, as compared to the same period of 2002, primarily due to an 8% increase in the sales of instruments for minimally-invasive and off-pump cardiac surgery to $3.3 million as a result of increased market penetration. Additionally, there was a 21% increase in the combined sales of surgical closures for cardiac surgery and surgical closures sold to original equipment manufacturers to $6.3 million for the three months ended March 31, 2003 as compared to the same period of 2002.

Service Revenue

Orthopaedics service revenue increased 45% to $6.1 million for the three months ended March 31, 2003, as compared to the same period of 2002, primarily due to the classification of $1.5 million of reimbursed expenses from partners as service revenue.

The 6% decrease in Biosurgical Specialties service revenue to $1.0 million for the three months ended March 31, 2003 as compared to same period of 2002 is attributable to decreased sales of Epicel skin grafts, which are used to treat victims of severe burns. Sales of Epicel skin grafts are variable based upon a number of unpredictable factors, including the number of severe burn patients and their survival rate prior to treatment with Epicel skin grafts.

International Revenue

International revenue as a percentage of total sales for the three months ended March 31, 2003 was 29% as compared to 31% in the same period of 2002. The decrease was primarily due to the increase in sales of Synvisc supplementation product in the U.S.

MARGINS

		Three Months Ended March 31,
		Three Months Ended March 31,						Increase/ (Decrease) % Change
		2003			2002			Increase/ (Decrease) % Change
		(Amounts in thousands, except percentage data)
Product margin		$	32,192		$	23,608		36	%
	% of product revenue		56	%		49	%
Service margin		$	3,529		$	2,175		62	%
	% of service revenue		50	%		42	%
Total gross margin		$	35,721		$	25,783		39	%
	% of total product and service revenue		55	%		48	%

Product Margin

The 36% increase in product margin and product margin as a percentage of product revenue for the three months ended March 31, 2003 as compared to the same period of 2002 was primarily attributable to an increase in product revenue of $9.3 million. The increase in product revenue was primarily due to an increase in sales of Synvisc viscosupplementation product due to increased utilization of the product within the existing customer base as well as the creation of new accounts, and an increase in sales of Sepra products due to increased market penetration.

Service Margin

Service margin for services allocated to Genzyme Biosurgery increased 62% for the three months ended March 31, 2003 as compared to the same period of 2002 and service margin as a percentage of service revenue increased primarily due to a 36% increase in sales of Orthopaedics services. This increase is a result of the classification of $1.5 million of reimbursed expenses from partners as service revenue.

OPERATING EXPENSES

Selling, General and Administrative

Selling, general and administrative expenses increased 11% for the three months ended March 31, 2003, as compared to the same period of 2002. The increase was primarily due to the creation of a sales force and an increase in sales operations in France in 2003 as we began to sell Synvisc viscosupplementation product directly to customers rather than through a distributor effective January 1, 2003. Also contributing to this increase was the classification of $1.5 million of reimbursed expenses from partners as service revenue. These increases were partially offset by an overall decrease in expenses relating to the Cardiac Devices business primarily due to increased operating efficiencies and reductions in staffing in 2002.

Research and Development

Research and development expenses increased 17% for the three months ended March 31, 2003, as compared to the same period of 2002. The increase was primarily due to a $1.3 million increase in spending on the Orthopaedics business product development programs, particularly other indications

for Synvisc viscosupplementation product and a $1.1 million increase in the Cardiac Science business product development programs, particularly cardiac cell therapy, as a result of clinical trials initiated during the three months ended March 31, 2003.

Amortization of Intangibles

There was no significant change in amortization of intangibles expense for the three months ended March 31, 2003, as compared to the same period of 2002.

Purchase of In-Process Research And Development

Biomatrix

In connection with our acquisition of Biomatrix, we allocated approximately $82.1 million to IPR&D, which Genzyme Biosurgery recorded as a charge to expense in its combined statement of operations for the year ended December 31, 2000. As of March 31, 2003, the technological feasibility of the Biomatrix IPR&D projects had not yet been reached and no significant departures from the assumptions included in the valuation analysis had occurred.

Below is a brief description of the Biomatrix IPR&D projects, including an estimation of when our management believes we may realize revenues from the sales of these products in the respective application:

Program	Program Description or Indication		Development Status at March 31, 2003	Value at Acquisition Date		Estimated Cost to Complete at March 31, 2003		Year of Expected Product Launch
				(in millions)
Viscosupplementation	Use of elastoviscous solutions and viscoelastic gels in disease conditions to supplement tissues and body fluids, alleviating pain and restoring normal function	• • • •	Received conditional FDA approval for hip indication clinical trial in U.S. Preclinical activities in U.S. and clinical trial in Europe for knee indications Preclinical for other joints Product launched for hip indication in Europe in September 2002	$	33.8	$	22.3	2002 to 2008
Visco-augmentation and Visco-separation (Adhesion prevention)	Use of viscoelastic gels to provide scaffolding for tissue regeneration and to separate tissues and decrease formation of adhesions and excessive scars after surgery	• • •	Preclinical—gynecological and pelvic indications Clinical trials—pivotal safety and efficacy study on-going in U.S. for Hylaform biomaterials. Phase 2—spine indications; program cancelled during 2002; no further development planned		48.3 N/A		4.2 N/A	2003 to 2006 N/A

			Total:	$	82.1	$	26.5

develop into products that can be marketed profitably. In addition, we cannot guarantee that we will be able to develop and commercialize products before our competitors develop and commercialize products for the same indications. If products based on our acquired IPR&D programs and technology platforms do not become commercially viable, our results of operations could be materially affected.

OTHER INCOME AND EXPENSE

		Three Months Ended March 31,
		Three Months Ended March 31,						Increase/ (Decrease) % Change
		2003			2002			Increase/ (Decrease) % Change
		(Amounts in thousands, except percentage data)
Other		$	(30	)	$	33		(191	)%
Investment income			219			297		(26	)%
Interest expense			(2,193	)		(2,245	)	(2	)%

	Total other expenses	$	(2,004	)	$	(1,915	)	5	%

Investment Income

Investment income decreased 26% for the three months ended March 31, 2003, as compared to the same period of 2002, as a result of a decrease in interest rates and decline average cash balances.

Interest Expense

Interest expense decreased in the three months ended March 31, 2003, as compared to the same period a year ago, primarily as a result of a decline in interest rates used to calculate interest on borrowings allocated to Genzyme Biosurgery from our revolving credit facility.

CUMULATIVE EFFECT OF CHANGE IN ACCOUNTING FOR GOODWILL

In November 2001, we sold our Snowden-Pencer line of surgical instruments. Our subsequent test of the remaining long-lived assets related to the remaining products of our surgical instruments and medical devices business line, which make up the majority of Genzyme Biosurgery's cardiothoracic reporting unit, under SFAS No. 121, did not indicate an impairment based on the undiscounted cash flows of the business. However, the impairment analysis indicated that the goodwill allocated to Genzyme Biosurgery's cardiothoracic reporting unit would be impaired if the analysis was done using discounted cash flows, as required by SFAS No. 142. Therefore, upon adoption of SFAS No. 142, Genzyme Biosurgery tested the goodwill of the cardiothoracic reporting unit in accordance with the transitional provisions of that standard, using the present value of expected future cash flows to estimate the fair value of this reporting unit. Genzyme Biosurgery recorded an impairment charge of $98.3 million, which was reflected as a cumulative effect of a change in accounting for goodwill in our consolidated statements of operations and the combined statements of operations for Genzyme Biosurgery for the three months ended March 31, 2002.

GENZYME MOLECULAR ONCOLOGY
A Division of Genzyme Corporation

The following discussion summarizes the key factors our management believes are necessary for an understanding of Genzyme Molecular Oncology's financial statements. When reviewing this discussion, you should keep in mind the substantial risks and uncertainties that characterize our business. In particular, we encourage you to review the risks and uncertainties described under "Factors Affecting Future Operating Results" in Exhibit 99.2 to our 2002 Form 10-K. These risks and uncertainties could cause actual results to differ materially from those forecast in forward-looking statements or implied by past results and trends. Forward-looking statements are statements that attempt to project or anticipate future developments in our business; we encourage you to review the examples of forward-looking statements under "Note Regarding Forward-Looking Statements." These statements, like all statements in this report, speak only as of the date of this report (unless another date is indicated) and we undertake no obligation to update or revise the statements in light of future developments.

CRITICAL ACCOUNTING POLICIES AND SIGNIFICANT ESTIMATES

The critical accounting policies and significant estimates for Genzyme Molecular Oncology are set forth under the heading "Management's Discussion and Analysis of Genzyme Molecular Oncology's Financial Condition and Results of Operations—Critical Accounting Policies and Significant Estimates" in Exhibit 13.4 to our 2002 Form 10-K. There have been no changes to these policies and no significant changes to these estimates since December 31, 2002.

REVENUES

The components of Genzyme Molecular Oncology's total revenues are described in the following table:

		Three Months Ended March 31,
		Three Months Ended March 31,				Increase/ (Decrease) % Change
		2003		2002		Increase/ (Decrease) % Change
		(Amounts in thousands, except percentage data)
Service revenue		$	—	$	300	(100	)%
Research and development revenue			1,477		1,469	1	%
Licensing revenue			704		653	8	%
Royalty revenue			7		—	N/A

	Total revenues	$	2,188	$	2,422	(10	)%

Service revenue for the three months ended March 31, 2002 consists of revenues from the provision of services related to the SAGE genomics technology. Genzyme Molecular Oncology provides these services sporadically as customers request them. The focus of its SAGE business remains directed to the grant of licenses to the technology. No service revenues were recorded for the three months ended March 31, 2003.

Research and development revenue for both the three months ended March 31, 2003 and 2002 consists of $1.5 million of revenue for research performed on behalf of:

•: Purdue under the cancer antigen discovery agreement that was initiated in October 2000; and
•: Kirin under a collaboration agreement related to the tumor endothelial marker (TEM) program that was initiated in November 2001.

Licensing revenue for the three months ended March 31, 2003 and March 31, 2002 consisted primarily of technology access fees Genzyme Molecular Oncology received from Purdue and Kirin

resulting from those collaborations. Genzyme Molecular Oncology is amortizing these fees over the course of the associated research programs. For the three months ended March 31, 2003, Genzyme Molecular Oncology recognized $0.7 million of the technology access fees it received from Purdue and Kirin, consistent with the same period of 2002. Genzyme Molecular Oncology also recognizes licensing revenue from licenses of rights to the SAGE technology.

Royalty revenue consists of royalties received under licenses to the SAGE technology.

COST OF REVENUES

		Three Months Ended March 31,
		Three Months Ended March 31,				Increase/ (Decrease) % Change
		2003		2002		Increase/ (Decrease) % Change
		(Amounts in thousands, except percentage data)
Cost of services sold		$	—	$	119	(100	)%
Cost of revenue from research and development contracts, licensing and royalty revenue			1,172		1,135	3	%

	Total cost of revenues	$	1,172	$	1,254	(7	)%

Genzyme Molecular Oncology's cost of services sold for the three months ended March 31, 2002 includes $0.1 million of costs associated with the performance of services using the SAGE technology.

Genzyme Molecular Oncology's cost of research and development contracts, licensing and royalty revenue for the three months ended March 31, 2003 and 2002 includes:

•: costs associated with work performed under funded research and development agreements, including those with Purdue and Kirin; and
•: royalties payable to third parties, most notably The Johns Hopkins University, for technology that Genzyme Molecular Oncology has licensed from them.

OPERATING EXPENSES

Selling, General and Administrative Expenses

Genzyme Molecular Oncology's selling, general and administrative expenses decreased 16% to $1.7 million for the three months ended March 31, 2003, as compared to the same period of 2002, primarily due to continued efforts within Genzyme Molecular Oncology to manage overall expenses and available cash.

Research and Development Expenses

Genzyme Molecular Oncology's research and development expenses decreased 21% to $4.2 million and total research and development expenses, including collaborator-funded expenses, decreased 17% to $5.4 million for the three months ended March 31, 2003. Both decreases are primarily due to a planned reduction in research and development spending as part of efforts to conserve available cash. Genzyme Molecular Oncology is managing its cash reserves closely by focusing its research and development spending on programs that it believes have the greatest potential for successful commercialization or valuable collaboration.

OTHER INCOME AND EXPENSES

Genzyme Molecular Oncology's other income decreased 44% to $0.1 million for the three months ended March 31, 2003, as compared to $0.2 million in the same period of 2002, primarily due to a decrease in investment income. Investment income decreased as a result of lower average cash balances.

B. LIQUIDITY AND CAPITAL RESOURCES

GENZYME CORPORATION

At March 31, 2003, we had cash, cash equivalents, and short- and long-term investments of $1.2 billion, an increase of $39.3 million from December 31, 2002.

Our operating activities generated $76.4 million of cash for the three months ended March 31, 2003, as compared to $22.7 million for the same period of 2002. Net cash provided by operating activities was primarily the result of our net income of $45.4 million and:

•: $35.6 million of depreciation and amortization, of which $18.1 million resulted from the depreciation of property, plant and equipment and $17.5 million resulted from the amortization of intangible assets; and
•: $4.2 million representing our equity in net losses of unconsolidated affiliates.

These increases were offset, in part, by a $5.8 million net increase in certain working capital accounts.

Our investing activities utilized $99.5 million in cash for the three months ended March 31, 2003, as compared to the $4.3 million of cash provided by our investing activities for the same period of 2002. Net cash utilized by investing activities consisted primarily of:

•: $49.0 million in cash utilized by the net purchases, sales and maturities of investments;
•: $45.8 million in cash used to fund purchases of plant, property and equipment, of which $26.9 million resulted from our manufacturing capacity expansion in Ireland, the United Kingdom and Belgium, $6.6 million resulted from our manufacturing capacity expansion in the U.S. and $12.3 million representing an aggregate of other manufacturing relocations, expansions and rehabilitations world-wide; and
•: $4.1 million in cash to fund our investments in unconsolidated affiliates.

In February 2003, the CPMP of the European Union issued a positive opinion on our MAA for Aldurazyme enzyme. This non-binding opinion has been forwarded to the EMEA for consideration and a final determination is expected later in 2003 regarding the marketing and sale of Aldurazyme enzyme in the European Union as a treatment for the non-neurological manifestations of MPS I in patients with a confirmed diagnosis of the disease. (See "Subsequent Events—Aldurazyme Enzyme" below.)

Our financing activities provided $11.3 million in cash for the three months ended March 31, 2003 as compared to $43.5 million provided for the same period of 2002. Cash provided by financing activities was primarily the result of:

•: $9.0 million of proceeds from the issuance of common stock under our stock plans; and
•: $2.3 million of cash resulting from the net increase in bank overdrafts.

The disclosure of payments we have committed to make under our contractual obligations is set forth under the heading "Management's Discussion and Analysis of Genzyme Corporation and Subsidiaries' Financial Condition and Results of Operations—Liquidity and Capital Resources" in

Exhibit 13.1 to our 2002 Form 10-K. There have been no material changes to our contractual obligations since December 31, 2002.

We believe that our available cash, investments and cash flow from operations will be sufficient to fund our planned operations and capital requirements for the foreseeable future. Although we currently have substantial cash resources and positive cash flow, we intend to use substantial portions of our available cash for:

•: product development and marketing;
•: expanding existing and constructing new facilities;
•: expanding staff;
•: working capital, including satisfaction of our obligations under capital and operating leases; and
•: strategic business initiatives.

Our cash reserves may be further reduced to pay the $10.0 million outstanding principal and accrued interest under our 6.9% convertible subordinated note due May 14, 2003, which may be converted into shares of Biosurgery Stock and to pay principal and interest on the $575.0 million in principal under our 3% convertible subordinated debentures due May 15, 2021, which may be converted into shares of Genzyme General Stock. Holders of the debentures may require us to repurchase all or part of their debentures for cash on May 15, 2006, 2011 or 2016, at a price equal to 100% of the principal amount of the debentures plus accrued interest through the date prior to the date of repurchase. Additionally, if certain fundamental changes occur, each holder may require us to repurchase, for cash, all or a portion of the holder's debentures. On or after May 20, 2004, we may redeem for cash all or part of the debentures that have not previously been converted or repurchased. The redemption price would be 100.75% of the principal amount if redeemed from May 20, 2004 through May 14, 2005, and 100% of the principal amount thereafter.

To satisfy these and other commitments, we may have to obtain additional financing. We cannot guarantee that we will be able to obtain any additional financing, extend any existing financing arrangement, or obtain either on favorable terms.

In 2001, Genzyme Limited, our wholly-owned subsidiary in the United Kingdom, established a home nursing and infusion service to support patients receiving Cerezyme enzyme and our other enzyme replacement therapies following the expiration of a contract with a third party service provider. This third party lodged a complaint with the Office of Fair Trading in the United Kingdom. The OFT is a non-governmental organization empowered to enforce certain consumer and competition legislation in the United Kingdom. The OFT commenced an investigation of this service, alleging that it contravened competition laws in the United Kingdom. While we believe that the provision of home healthcare services by our subsidiary and our pricing for Cerezyme enzyme in the United Kingdom fully complies with applicable laws, we cooperated in this investigation. On March 27, 2003, the OFT ruled that this service did, in fact, violate United Kingdom competition law, and as a result fined Genzyme Limited approximately 6.8 million Pounds Sterling and required modifications to our pricing structure for Cerezyme enzyme in the United Kingdom. We have appealed this finding to the United Kingdom Competition Appeal Tribunal, receiving an automatic stay of the fine, and seeking a stay of the order on Cerezyme pricing. Hearings were held on April 16, 2003 and May 1, 2003 regarding the stay of the OFT's decision. On May 6, 2003, the Tribunal issued an order that stays the OFT's decision but which requires Genzyme Limited to provide one supplier a modest discount during the pendancy of the appeal process. We are confident that we will prevail on appeal and believe it probable that we will not have to pay a material fine or permanently modify our Cerezyme pricing structure. We have not accrued any amounts in connection with this contingency.

The staff of the FTC is investigating our acquisition of Novazyme. The FTC is one of the agencies responsible for enforcing federal antitrust laws. While we do not believe that the acquisition should be deemed to contravene antitrust laws, we have been cooperating with the FTC in its investigation which is currently ongoing.

On April 17, 2002, SPI initiated dispute resolution procedures alleging that we breached representations and warranties and committed fraud and intentional conduct relating to the sale of our Snowden-Pencer line of surgical instruments to SPI in November 2001. On April 7, 2003, SPI filed a notice of arbitration with the American Arbitration Association. An arbitration hearing is anticipated to take place within the next 60-90 days. We believe the claims made by SPI are without merit and intend to vigorously defend the claims. Based on the advice of counsel, management does not believe that it is probable that we will be required to pay a material amount in connection with this claim. We have not accrued any amounts in connection with this contingency.

New Accounting Pronouncements

In January 2003, the FASB issued FIN 46, "Consolidation of Variable Interest Entities, an interpretation of ARB No. 51." FIN 46 requires existing unconsolidated variable interest entities to be consolidated by their primary beneficiaries if the entities do not effectively disperse risks among parties involved. Variable interest entities that effectively disperse risk will not be consolidated unless a single party holds an interest or combination of interests that effectively recombines risks that were previously dispersed. FIN 46 also requires enhanced disclosure requirements related to variable interest entities. FIN 46 applies immediately to variable interest entities created after January 31, 2003, and to variable interest entities in which an enterprise obtains an interest after that date. It applies in the first fiscal year or interim period beginning after June 15, 2003 to variable interest entities in which an enterprise holds a variable interest that it acquired before February 1, 2003.

Subsequent Events

Fabrazyme Enzyme

On April 24, 2003, the FDA granted marketing approval for Fabrazyme enzyme for Fabry disease. Fabrazyme has received Orphan Drug designation, which provides seven years of market exclusivity in the U.S. We have agreed with the FDA on a number of post-marketing commitments, including:

•: completing the ongoing phase 4 study in its placebo-controlled form and taking steps to preserve the integrity of this trial. This study is fully enrolled and currently includes more than 70 patients. The trial is evaluating the effectiveness of Fabrazyme in the time to clinically significant deterioration in any of the following: renal function, cardiac function, CNS disease, or death;
•: after completing the phase 4 verification study, regularly evaluating the creatinine levels of those patients through an open-label extension study;
•: obtaining long-term clinical status information on the Fabry population through the Fabry Registry we established two years ago to track the natural history and clinical outcomes of patients with Fabry disease; and

•: completing our ongoing safety and pharmacodynamic study of Fabrazyme in pediatric patients.

Aldurazyme Enzyme

On April 30, 2003, the FDA granted marketing approval for Aldurazyme enzyme as an enzyme replacement therapy for people with MPS I. Aldurazyme is indicated for patients with the Hurler and Hurler-Scheie forms of MPS I, and for Scheie patients with moderate to severe symptoms. Aldurazyme has been granted Orphan Drug status in the U.S., which provides seven years of market exclusivity. Together with our partner BioMarin, we have agreed with the FDA on post-marketing commitments, including:

•: completing our study that was initiated in December 2002 to evaluate the safety and pharmacokinetics of Aldurazyme in patients less than 5 years of age;
•: conducting an open-label dose optimization study in approximately 32 patients, and continue the phase 3 extension study for a total of 4 years from study initiation; and
•: in a registry setting, obtaining long-term information related to the natural history of MPS I and the safety and efficacy of Aldurazyme.

We will commercialize Aldurazyme in the U.S. Aldurazyme will be manufactured at BioMarin's plant in California and sent to either our manufacturing facility in Allston, Massachusetts or to a third-party facility for the final filing and finish process. Pursuant to the terms of our joint venture agreement with BioMarin, we are obligated to pay BioMarin a $12.1 million milestone payment upon receipt of FDA approval of the Aldurazyme enzyme BLA.

GENZYME GENERAL
A Division of Genzyme Corporation

At March 31, 2003, Genzyme General had cash, cash equivalents, and short- and long-term investments of $1.2 billion, an increase of $56.4 million from December 31, 2002.

Genzyme General's operating activities generated $94.9 million of cash for the three months ended March 31, 2003, as compared to $47.4 million for the same period of 2002. Net cash provided by operating activities was favorably impacted by Genzyme General's division net income of $57.8 million, and:

•: $26.3 million of depreciation and amortization, of which $16.6 million resulted from the depreciation of property, plant and equipment and $9.7 million resulted from the amortization of intangible assets; and
•: $4.2 million in cash provided from the equity in net losses of unconsolidated affiliates.

These favorable impacts were supplemented by a $7.3 million net decrease in certain working capital accounts.

Genzyme General's investing activities utilized $103.4 million of cash for the three months ended March 31, 2003, as compared to providing $17.7 million for the same period of 2002. Net cash utilized by investing activities consisted primarily of:

•: $53.7 million of cash utilized by Genzyme General's net purchases, sales and maturities of investments;
•: $45.0 million to fund purchases of property, plant and equipment, of which $26.9 million resulted from the expansion of our manufacturing facilities in Ireland, the United Kingdom and Belgium, $6.6 million resulted from our manufacturing capacity expansion in the U.S. and $11.5 million representing an aggregate of other manufacturing relocations, expansions and rehabilitations worldwide; and
•: $4.1 million of cash to fund Genzyme General's investments in unconsolidated affiliates.

In February 2003, the CPMP of the European Union issued a positive opinion on the MAA for Aldurazyme enzyme. This non-binding opinion has been forwarded to the EMEA for consideration and a final determination is expected later in 2003 regarding the marketing and sale of Aldurazyme enzyme in the European Union as a treatment for the non-neurological manifestations of MPS I in patients with a confirmed diagnosis of the disease (see "Subsequent Events—Aldurazyme Enzyme" below.)

Genzyme General's financing activities provided $8.6 million of cash for the three months ended March 31, 2003, as compared to $33.7 million provided for the same period of 2002. Cash provided by financing activities was primarily the result of $8.7 million of cash provided from the issuance of common stock partially offset by $0.3 million of cash used to repay bank overdrafts.

Genzyme General has access to our $350.0 million revolving credit facility, all of which matures in December 2003. At March 31, 2003, $284.0 million was outstanding under this facility, all of which was allocated to Genzyme Biosurgery. Borrowings under this facility bear interest at LIBOR plus an applicable margin, which was, in the aggregate, 2.5% at March 31, 2003. We intend to refinance our revolving credit facility prior to its expiration in December 2003.

Our board of directors has made $25.0 million of Genzyme General's cash available to Genzyme Biosurgery. Under this arrangement, Genzyme Biosurgery is able to draw down funds as needed in exchange for Biosurgery designated shares based on the fair market value (as defined in our charter) of Biosurgery Stock at the time of the draw. At March 31, 2003, $3.0 million remained available to Genzyme Biosurgery under this arrangement. Our board of directors has also made $30.0 million of

Genzyme General's cash available to Genzyme Molecular Oncology. Under this arrangement, Genzyme Molecular Oncology is able to draw down funds as needed in exchange for Molecular Oncology designated shares based on the fair market value (as defined in our charter) of Molecular Oncology Stock at the time of the draw. At March 31, 2003, $11.0 million remained available to Genzyme Molecular Oncology under this arrangement.

The disclosure of payments we have committed to make under contractual obligations using cash allocated to Genzyme General is set forth under the heading "Management's Discussion and Analysis of Genzyme General's Financial Condition and Results of Operations—Liquidity and Capital Resources" in Exhibit 13.2 to our 2002 Form 10-K. There have been no material changes to the contractual obligations allocated to Genzyme General since December 31, 2002.

We believe that Genzyme General's available cash, investments and cash flow from operations will be sufficient to fund its planned operations and capital requirements for the foreseeable future. Although Genzyme General currently has substantial cash resources and positive cash flow, it intends to use substantial portions of its available cash for:

•: product development and marketing;
•: expanding existing and constructing new facilities;
•: expanding staff;
•: working capital, including satisfaction of our obligations under capital and operating leases; and
•: strategic business initiatives.

Genzyme General's cash resources will be reduced to the extent that we are required to use cash allocated to Genzyme General to settle the liabilities of Genzyme Biosurgery or Genzyme Molecular Oncology. In addition, Genzyme General's cash reserves will be further reduced to pay principal and interest on the $575.0 million in principal under our 3% convertible subordinated debentures due May 15, 2021, which may be converted into shares of Genzyme General Stock. Holders of the debentures may require us to repurchase all or part of their debentures for cash on May 15, 2006, 2011 or 2016, at a price equal to 100% of the principal amount of the debentures plus accrued interest through the date prior to the date of repurchase. Additionally, if certain fundamental changes occur, each holder may require us to repurchase, for cash, all or a portion of the holder's debentures. On or after May 20, 2004, we may redeem for cash all or part of the debentures that have not previously been converted or repurchased. The redemption price would be 100.75% of the principal amount if redeemed from May 20, 2004 through May 14, 2005, and 100% of the principal amount thereafter.

To satisfy these and other commitments, we may have to obtain additional financing for Genzyme General. We cannot guarantee that we will be able to obtain any additional financing, extend any existing financing arrangement, or obtain either on favorable terms.

Competition Appeal Tribunal, receiving an automatic stay of the fine, and seeking a stay of the order on Cerezyme pricing. Hearings were held on April 16, 2003 and May 1, 2003 regarding the stay of the OFT's decision. On May 6, 2003, the Tribunal issued an order that stays the OFT's decision but which requires Genzyme Limited to provide one supplier a modest discount during the pendancy of the appeal process. We are confident that we will prevail on appeal and believe it probable that we will not have to pay a material fine or permanently modify our Cerezyme pricing structure. Genzyme General has not accrued any amounts in connection with this contingency.

Subsequent Events

Fabrazyme Enzyme

•: completing the ongoing phase 4 study in its placebo-controlled form and taking steps to preserve the integrity of this trial. This study is fully enrolled and currently includes more than 70 patients. The trial is evaluating the effectiveness of Fabrazyme in the time to clinically significant deterioration in any of the following: renal function, cardiac function, CNS disease, or death;
•: after completing the phase 4 verification study, regularly evaluating the creatinine levels of those patients through an open-label extension study;
•: obtaining long-term clinical status information on the Fabry population through the Fabry Registry we established two years ago to track the natural history and clinical outcomes of patients with Fabry disease; and
•: completing our ongoing safety and pharmacodynamic study of Fabrazyme in pediatric patients.

Aldurazyme Enzyme

•: completing our study that was initiated in December 2002 to evaluate the safety and pharmacokinetics of Aldurazyme in patients less than 5 years of age;
•: conducting an open-label dose optimization study in approximately 32 patients, and continue the phase 3 extension study for a total of 4 years from study initiation; and
•: in a registry setting, obtaining long-term information related to the natural history of MPS I and the safety and efficacy of Aldurazyme.

GENZYME BIOSURGERY
A Division of Genzyme Corporation

At March 31, 2003, Genzyme Biosurgery had cash and cash equivalents of $22.0 million, a decrease of $10.8 million from December 31, 2002.

Genzyme Biosurgery's operating activities used $12.2 million of cash for the three months ended March 31, 2003, as compared to $16.0 million for the same period of 2002. Net cash used by operating activities was impacted by:

•: Genzyme Biosurgery's division net loss of $14.1 million; and
•: a net increase in certain working capital accounts of $7.5 million.

These items impacting operating activities were offset by $9.3 million provided by depreciation and amortization, of which, $1.5 million resulted from the depreciation of property, plant and equipment and $7.8 million resulted from the amortization of intangible assets, including intangible assets acquired in connection with our acquisitions of Biomatrix and Focal.

Genzyme Biosurgery's investing activities used $1.2 million in cash for the three months ended March 31, 2003, as compared to $0.8 million for the same period of 2002.

Genzyme Biosurgery's financing activities provided $2.7 million in cash for the three months ended March 31, 2003, as compared to $9.7 million for the same period of 2002. primarily due to bank overdrafts.

In connection with our acquisition of Biomatrix, we assumed a 6.9% convertible subordinated note due May 14, 2003, in favor of UBS Warburg LLC. The $10.0 million principal of this note remains outstanding and was included in current portion of long-term debt, convertible notes and capital lease obligations in Genzyme Biosurgery's combined balance sheet at March 31, 2003.

Genzyme Biosurgery has access to our $350.0 million revolving credit facility, all of which matures in December 2003. At March 31, 2003, $284.0 million was outstanding under this facility, all of which was allocated to Genzyme Biosurgery. Borrowings under this facility bear interest at LIBOR plus an applicable margin, which was, in aggregate, 2.5% at March 31, 2003. We intend to refinance our revolving credit facility prior to its expiration in December 2003.

In March 2003, we entered into a collaboration with Excigen, a recently created biotechnology company in Baltimore, Maryland focused on developing gene therapies for treating cardiac arrhythmias. In connection with the collaboration, we acquired 1,440,000 shares of the convertible preferred stock of Excigen and a warrant to acquire an additional 865,882 shares of convertible preferred stock, in exchange for our commitment to provide Excigen with up to $2.3 million in funding and $2.3 million worth of research, clinical, regulatory and manufacturing services, which services are to be provided by Genzyme Biosurgery. We provided the initial $0.4 million of the cash commitment in March 2003, with the balance of $1.9 million to be paid in future installments. We allocate our ownership interest in Excigen to Genzyme Biosurgery.

The disclosure of payments we have committed to make under contractual obligations using cash allocated to Genzyme Biosurgery is set forth under the heading "Management's Discussion and Analysis of Genzyme Biosurgery's Financial Condition and Results of Operations—Liquidity and Capital Resources" in Exhibit 13.3 to our 2002 Form 10-K. Excluding the agreements with Excigen

described above, there have been no material changes to the contractual obligations allocated to Genzyme Biosurgery since December 31, 2002.

We anticipate that Genzyme Biosurgery's cash resources, together with amounts available from the following sources, will be sufficient to finance its planned operations and capital requirements through at least the end of 2003:

•: revenues generated from sales of its products and sales under distribution agreements;
•: the $3.0 million remaining available under the interdivisional financing arrangement with Genzyme General; and
•: amounts available to Genzyme Biosurgery under our revolving credit facility.

Genzyme Biosurgery intends to use substantial portions of its available cash for:

•: repayment of the 6.9% convertible subordinated note due in May 2003;
•: research and development;
•: product development and marketing;
•: improving manufacturing efficiency;
•: enforcing patent and other intellectual property rights;
•: transactional activity related to acquiring and disposing of assets;
•: consolidating facilities and related relocation activities; and
•: working capital.

Genzyme Biosurgery's cash needs may differ from those planned as a result of many factors, including the:

•: results of research and development efforts;
•: ability to establish and maintain strategic alliance;
•: ability to enter into licensing arrangements and additional distribution arrangements;
•: ability to share costs of product development with research and marketing partners;
•: costs involved in enforcing patent claims and other intellectual property rights;
•: costs involved in defending or settling post-closing acquired liabilities in connection with our sale of the Snowden-Pencer line of surgical instruments;
•: market acceptance of novel approaches and therapies;
•: success of its initiatives to reduce expenses and streamline its operations;
•: development of competitive products; and
•: ability to satisfy regulatory requirements of the FDA and other governmental authorities.

Genzyme Biosurgery will require significant additional financing to continue operations at anticipated levels. We cannot guarantee that we will be able to obtain any additional financing, extend any existing financing arrangement, or obtain either on terms that we consider favorable. If Genzyme Biosurgery has insufficient funds or is unable to raise additional funds, it may delay, scale back or eliminate certain of its programs or collaborations with third parties. Genzyme Biosurgery may also have to give third parties rights to commercialize technologies or products that it would otherwise have sought to commercialize itself.

On April 17, 2002, SPI initiated dispute resolution procedures alleging that we breached representations and warranties and committed fraud and intentional conduct relating to the sale of our Snowden-Pencer line of surgical instruments to SPI in November 2001. On April 7, 2003, SPI filed a notice of arbitration with the American Arbitration Association. An arbitration hearing is anticipated to take place within the next 60-90 days. We believe the claims made by SPI are without merit and intend to vigorously defend the claims. Based on the advice of counsel, management does not believe that it is probable that we will be required to pay a material amount in connection with this claim. Genzyme Biosurgery has not accrued any amounts in connection with this contingency.

GENZYME MOLECULAR ONCOLOGY
A Division of Genzyme Corporation

At March 31, 2003, Genzyme Molecular Oncology had cash, cash equivalents and short-term investments of $6.8 million, a decrease of $6.4 million from December 31, 2002.

Genzyme Molecular Oncology's operating activities used $6.4 million of cash for the three months ended March 31, 2003, as compared to $8.6 million for the same period of 2002. Operating activities were impacted by Genzyme Molecular Oncology's division net loss of $4.8 million for the three months ended March 31, 2003 and by $1.6 million attributable to a net increase in certain working capital accounts in the same period.

Genzyme Molecular Oncology's investing activities provided $5.0 million of cash for the three months ended March 31, 2003, as compared to utilizing $12.6 million in the same period of 2002. Net cash provided by investing activities was attributable to the sales and maturities of investments.

Genzyme Molecular Oncology's financing activities for the three months ended March 31, 2003 provided $0.1 million of allocated proceeds from the issuance of Molecular Oncology Stock under our stock purchase program.

Genzyme Molecular Oncology has access to our $350.0 million revolving credit facility that matures in December 2003, of which $66.0 million remained available for borrowing at March 31, 2003. We intend to refinance our revolving credit facility prior to its expiration in December 2003.

Our board of directors has made $30.0 million of Genzyme General's cash available to Genzyme Molecular Oncology. Under this arrangement, Genzyme Molecular Oncology is able to draw down funds as needed in exchange for Molecular Oncology designated shares based on the fair market value (as defined in our charter) of Molecular Oncology Stock at the time of the draw. At March 31, 2003, $11.0 million remained available to Genzyme Molecular Oncology under this arrangement.

We anticipate that Genzyme Molecular Oncology's current cash resources, together with amounts available from the following sources, will be sufficient to fund its anticipated operations through the end of 2003:

•: committed and anticipated research funding and licensing income from collaborators;
•: the $11.0 million remaining available under the interdivisional financing arrangement with Genzyme General; and
•: amounts available to Genzyme Molecular Oncology under our revolving credit facility.

Genzyme Molecular Oncology plans to spend substantial amounts of funds on, among other things:

•: research and development;
•: preclinical and clinical testing;
•: pursuing regulatory approvals; and
•: working capital.

Genzyme Molecular Oncology's cash needs may differ from those planned as a result of many factors, including the:

•: results of research and development and clinical testing;
•: achievement of milestones under existing licensing arrangements;
•: ability to establish and maintain additional strategic collaborations and licensing arrangements;

•: costs involved in enforcing patent claims and other intellectual property rights;
•: market acceptance of novel approaches and therapies;
•: development of competing products and services; and
•: ability to satisfy the regulatory requirements of the FDA and other government authorities.

The disclosure of payments we have committed to make under contractual obligations using cash allocated to Genzyme Molecular Oncology is set forth under the heading "Management's Discussion and Analysis of Genzyme Molecular Oncology's Financial Condition and Results of Operations—Liquidity and Capital Resources" in Exhibit 13.4 to our 2002 Form 10-K. There have been no material changes to the contractual obligations allocated to Genzyme Molecular Oncology since December 31, 2002.

Genzyme Molecular Oncology will require significant additional financing to continue operations at anticipated levels. We cannot guarantee that Genzyme Molecular Oncology will be able to obtain any additional financing, extend any existing financing arrangement, or obtain either on terms that we consider favorable. To this end, management is managing its cash reserves closely by focusing its research and development spending on programs that it believes have the greatest potential for successful commercialization or valuable collaboration. If Genzyme Molecular Oncology has insufficient funds or is unable to raise additional funds, it may delay, reduce or eliminate certain of its programs. Genzyme Molecular Oncology may also have to sell or give to third parties rights to commercialize technologies or products that it would otherwise have sought to commercialize itself.

ITEM 3. QUANTITATIVE AND QUALITATIVE ANALYSIS OF MARKET RISK

We are exposed to potential loss from financial market risks that may occur as a result of changes in interest rates, equity prices and foreign currency exchange rates. Our exposure to these risks has not materially changed since December 31, 2002.

We incorporate by reference our disclosure related to market risk which is set forth under the heading "Management's Discussion and Analysis of Genzyme Corporation and Subsidiaries' Financial Condition and Results of Operations—Market Risk," "—Interest Rate Risk," "—Foreign Exchange Risk" and "—Equity Price Risk" in Exhibit 13.1 to our 2002 Form 10-K.

ITEM 4. CONTROLS AND PROCEDURES

Our chief executive officer and our chief financial officer evaluated the effectiveness of our disclosure controls and procedures (as defined in Rules 13(a)-14 and 15(d)-14 under the Securities Exchange Act of 1934) as of a date (the "Evaluation Date") within 90 days before the filing date of this quarterly report. Based upon that evaluation, our chief executive officer and our chief financial officer have concluded that, as of the Evaluation Date, our disclosure controls and procedures were effective in ensuring that they received, in a timely manner, the information that we and our consolidated subsidiaries are required to disclose in the reports filed or submitted by us under the Securities Exchange Act of 1934. There were no significant changes in our internal controls or in other factors that could significantly affect our disclosure controls and procedures subsequent to the Evaluation Date.

PART II. OTHER INFORMATION

ITEM 2. CHANGES IN SECURITIES

ITEM 6. EXHIBITS AND REPORTS ON FORM 8-K

(a): Exhibits

See the Exhibit Index immediately following the signature page to this report on Form 10-Q.

(b): Reports on Form 8-K

On January 10, 2003, we filed a Current Report on Form 8-K dated January 10, 2003 to provide information relating to the adjusted voting rights for Biosurgery Stock and Molecular Oncology Stock as of January 1, 2003 as required under our Restated Articles of Organization, as amended.

On April 16, 2003, we filed a Current Report on Form 8-K dated April 16, 2003 to include press releases to be issued on that date relating to the anticipated results of operations for each of our operating divisions—Genzyme General, Genzyme Biosurgery and Genzyme Molecular Oncology. We submitted these press releases to the SEC pursuant to Item 9 (Regulation FD Disclosure) and Item 12 (Results of Operations and Financial Condition).

GENZYME CORPORATION AND SUBSIDIARIES
FORM 10-Q, MARCH 31, 2003

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.

		GENZYME CORPORATION
		By:		/s/ MICHAEL S. WYZGA Michael S. Wyzga Senior Vice President, Finance, Chief Financial Officer, and Chief Accounting Officer

DATE: May 7, 2003

100

CERTIFICATION

I, Henri A. Termeer, certify that:

1. I have reviewed this quarterly report on Form 10-Q of Genzyme Corporation (the "Registrant");

2. Based on my knowledge, this quarterly report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this quarterly report;

3. Based on my knowledge, the financial statements, and other financial information included in this quarterly report, fairly present in all material respects the financial condition, results of operations and cash flows of the Registrant as of, and for, the periods presented in this quarterly report;

4. The Registrant's other certifying officer and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-14 and 15d-14) for the Registrant and we have:

a) designed such disclosure controls and procedures to ensure that material information relating to the Registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this quarterly report is being prepared;

b) evaluated the effectiveness of the Registrant's disclosure controls and procedures as of a date within 90 days prior to the filing date of this quarterly report (the "Evaluation Date"); and

c) presented in this quarterly report our conclusions about the effectiveness of the disclosure controls and procedures based on our evaluation as of the Evaluation Date;

5. The Registrant's other certifying officer and I have disclosed, based on our most recent evaluation, to the Registrant's auditors and the audit committee of Registrant's board of directors (or persons performing the equivalent function):

a) all significant deficiencies in the design or operation of internal controls which could adversely affect the Registrant's ability to record, process, summarize and report financial data and have identified for the Registrant's auditors any material weaknesses in internal controls; and

b) any fraud, whether or not material, that involves management or other employees who have a significant role in the Registrant's internal controls; and

6. The Registrant's other certifying officer and I have indicated in this quarterly report whether or not there were significant changes in internal controls or in other factors that could significantly affect internal controls subsequent to the date of our most recent evaluation, including any corrective actions with regard to significant deficiencies and material weaknesses.

Date: May 7, 2003

/s/ HENRI A. TERMEER

Henri A. Termeer
Chief Executive Officer

101

CERTIFICATION

I, Michael S. Wyzga, certify that:

1. I have reviewed this quarterly report on Form 10-Q of Genzyme Corporation (the "Registrant");

b) evaluated the effectiveness of the Registrant's disclosure controls and procedures as of a date within 90 days prior to the filing date of this quarterly report (the "Evaluation Date"); and

c) presented in this quarterly report our conclusions about the effectiveness of the disclosure controls and procedures based on our evaluation as of the Evaluation Date;

b) any fraud, whether or not material, that involves management or other employees who have a significant role in the Registrant's internal controls; and

Date: May 7, 2003

/s/ MICHAEL S. WYZGA

Michael S. Wyzga
Chief Financial Officer

102

GENZYME CORPORATION AND SUBSIDIARIES
FORM 10-Q, MARCH 31, 2003

EXHIBIT INDEX

Exhibit No.		Description
*3.1		Restated Articles of Organization of Genzyme Corporation, as amended. Filed as Exhibit 3 to Genzyme's Form 8-K filed on June 6, 2001.
*3.2		By laws of Genzyme, as amended. Filed as Exhibit 3.2 to Genzyme's Form 10-Q for the quarter ended September 30, 1999.
99.1		Written Statement of the Chief Executive Officer. Filed herewith.
99.2		Written Statement of the Chief Financial Officer. Filed herewith.

*: Indicates an exhibit previously filed with the SEC under Commission File No. 0-14680 and incorporated herein by reference.