EX-1 2 a2031159zex-1.txt EXHIBIT 1 Directors of Genzyme -------------------- Set forth below is the name, present principal occupation or employment and the name, principal business and address of any corporation or other organization in which such employment is conducted of each director of Genzyme. Unless otherwise indicated, each director is a citizen of the United States. Henri A. Termeer Chairman of the Board, President and Chief Executive Officer Genzyme Corporation One Kendall Square Cambridge, Massachusetts 02139 Constantine E. Anagnostopoulos Managing General Partner Gateway Associates (venture capital firm) 8000 Maryland Avenue, Suite 1190 Clayton, MO 63105 Douglas A. Berthiaume Chairman, President and Chief Executive Officer Waters Corporation (high technology manufacturer of products used for analysis and purification) 34 Maple Street Milford, Massachusetts 01757 Henry E. Blair President and Chief Executive Officer Dyax Corp. (bioseparation, pharmaceutical discovery and development company) One Kendall Square, Building 600, 5th Floor Cambridge, Massachusetts 02139 Robert J. Carpenter Chairman GelTex Pharmaceuticals, Inc. (pharmaceutical development company) 153 Second Avenue Waltham, Massachusetts 02451 Charles L. Cooney Professor of Chemical and Biochemical Engineering Massachusetts Institute of Technology 25 Ames Street Building 66-Room 352 Cambridge, Massachusetts 02139 Victor J. Dzau Professor of the Theory and Practice of Physic Harvard Medical School 25 Shattuck Street Boston, Massachusetts 02115 (Page 11 of 12 pages) Executive Officers of Genzyme ----------------------------- Set forth below is the name and present principal occupation of each of the executive officers of Genzyme. Unless otherwise indicated, each executive officer is a citizen of the United States and has as his principal business address One Kendall Square, Cambridge, Massachusetts 02139. Henri A. Termeer Chairman of the Board, President and Chief Executive Officer Earl M. Collier, Jr. Executive Vice President, President, Genzyme Surgical Products Division Zoltan A. Csimma Senior Vice President, Human Resources David D. Fleming Group Senior Vice President, Diagnostic Products Richard A. Moscicki, M.D. Senior Vice President, Clinical, Medical and Regulatory Affairs; Chief Medical Officer Alan E. Smith, Ph.D. Senior Vice President, Research; Chief Scientific Officer Citizenship: United Kingdom G. Jan van Heek Executive Vice President, Therapeutics and Genetics Citizenship: The Netherlands Peter Wirth Executive Vice President; Chief Legal Officer; Clerk Michael S. Wyzga Senior Vice President, Finance; Chief Financial Officer; Corporate Controller; Chief Accounting Officer (Page 12 of 12 pages)