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Proc-Type: 2001,MIC-CLEAR
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<SEC-DOCUMENT>0000732485-04-000005.txt : 20040210
<SEC-HEADER>0000732485-04-000005.hdr.sgml : 20040210
<ACCEPTANCE-DATETIME>20040210144957
ACCESSION NUMBER:		0000732485-04-000005
CONFORMED SUBMISSION TYPE:	4/A
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20030630
FILED AS OF DATE:		20040210

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			COLLIER EARL M JR
		CENTRAL INDEX KEY:			0001201254

	FILING VALUES:
		FORM TYPE:		4/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	333-90510
		FILM NUMBER:		04581470

	MAIL ADDRESS:	
		STREET 1:		GENZYME CORP
		STREET 2:		ONE KENDALL SQUARE
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02139

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			GENZYME CORP
		CENTRAL INDEX KEY:			0000732485
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				061047163
		STATE OF INCORPORATION:			MA
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		ONE KENDALL SQ
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02139
		BUSINESS PHONE:		6172527500

	MAIL ADDRESS:	
		STREET 1:		ONE KENDALL SQUARE
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02139
</SEC-HEADER>
<DOCUMENT>
<TYPE>4/A
<SEQUENCE>1
<FILENAME>col108.xml
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    <footnotes>
        <footnote id="F1">On June 30, 2003 all outstanding shares of Genzyme Biosurgery and Genzyme Molecular stock were exchanged for shares of Genzyme General Stock.  Genzyme Biosurgery shareholders received .04914 of a share of Genzyme General stock for each Biosurgery share and Genzyme Molecular Oncology shareholders received .05653 of a share of Genzyme General stock for each Molecular Oncology share.</footnote>
        <footnote id="F2">On June 30, 2003 in relation to the elimination of Genzyme's tracking stock structure, all stock options of Genzyme Biosurgery and Genzyme Molecular were exchanged for stock options of Genzyme General.  The exchange ratio was based on the closing prices of all three stocks on 6/30/03.  Genzyme Biosurgery options were exchanged at a rate of .04945 and Genzyme Molecular Oncology options were exchanged at a rate of .05614.</footnote>
        <footnote id="F3">Options vest in 20% annual increments beginning on the original date of grant.</footnote>
        <footnote id="F4">Options vest 20% on October 16, 1997 and in 20% annual increments beginning May 16, 1998.</footnote>
        <footnote id="F5">Options were granted with an exercise price 100% above fair market value, and vest in 1/3 increments on each of Janary 25, 2001, 2002 and 2003.</footnote>
        <footnote id="F6">Options vest 20% on August 26, 1999 and in 20% annual increments beginning May 26, 2000.</footnote>
        <footnote id="F7">Options vest in 25% annual increments on July 17, 2001, 2002, 2003 and 2004.</footnote>
    </footnotes>

    <remarks></remarks>

    <ownerSignature>
        <signatureName>By: Susan P. Cogswell, Attorney-in-Fact</signatureName>
        <signatureDate>2004-02-10</signatureDate>
    </ownerSignature>
</ownershipDocument>

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