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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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<SEC-DOCUMENT>0000732485-03-000065.txt : 20031022
<SEC-HEADER>0000732485-03-000065.hdr.sgml : 20031022
<ACCEPTANCE-DATETIME>20031022141250
ACCESSION NUMBER:		0000732485-03-000065
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20031020
FILED AS OF DATE:		20031022

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			GENZYME CORP
		CENTRAL INDEX KEY:			0000732485
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				061047163
		STATE OF INCORPORATION:			MA
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		ONE KENDALL SQ
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02139
		BUSINESS PHONE:		6172527500

	MAIL ADDRESS:	
		STREET 1:		ONE KENDALL SQUARE
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02139

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			TERMEER HENRI A
		CENTRAL INDEX KEY:			0001021038
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		STATE OF INCORPORATION:			MA
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	333-90510
		FILM NUMBER:		03951596

	BUSINESS ADDRESS:	
		STREET 1:		C/O GENZYME CORP
		STREET 2:		ONE KENDALL SQ
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02139
		BUSINESS PHONE:		6172527500

	MAIL ADDRESS:	
		STREET 1:		ONE KENDALL SQUARE
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02139
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>ter91.xml
<TEXT>
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        <issuerName>GENZYME CORP</issuerName>
        <issuerTradingSymbol>GENZ</issuerTradingSymbol>
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            <rptOwnerName>TERMEER HENRI A</rptOwnerName>
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            <rptOwnerStreet2>ONE KENDALL SQUARE</rptOwnerStreet2>
            <rptOwnerCity>CAMBRIDGE</rptOwnerCity>
            <rptOwnerState>MA</rptOwnerState>
            <rptOwnerZipCode>021391562</rptOwnerZipCode>
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			<isDirector>1</isDirector>
			<isOfficer>1</isOfficer>
			<isTenPercentOwner>0</isTenPercentOwner>
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			<officerTitle>Chmn, President and CEO</officerTitle>
		</reportingOwnerRelationship>
	</reportingOwner>
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			<transactionAmounts>
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				<transactionPricePerShare>
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				</transactionPricePerShare>
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				<transactionPricePerShare>
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		<nonDerivativeTransaction>
			<securityTitle>
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			</securityTitle>
			<transactionDate>
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			</transactionDate>
			<deemedExecutionDate>
			</deemedExecutionDate>
			<transactionCoding>
				<transactionFormType>4</transactionFormType>
				<transactionCode>S</transactionCode>
				<equitySwapInvolved>0</equitySwapInvolved>
			</transactionCoding>
			<transactionAmounts>
				<transactionShares>
					<value>100000</value>
				</transactionShares>
				<transactionPricePerShare>
					<value>49.00</value>
				</transactionPricePerShare>
				<transactionAcquiredDisposedCode>
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			</transactionAmounts>
			<postTransactionAmounts>
				<sharesOwnedFollowingTransaction>
					<value>686129</value>
					<footnoteId id="F1"/>
				</sharesOwnedFollowingTransaction>
			</postTransactionAmounts>
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				<directOrIndirectOwnership>
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					<value/>
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			</securityTitle>
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				<sharesOwnedFollowingTransaction>
					<value>16438</value>
				</sharesOwnedFollowingTransaction>
			</postTransactionAmounts>
			<ownershipNature>
				<directOrIndirectOwnership>
					<value>I</value>
				</directOrIndirectOwnership>
				<natureOfOwnership>
					<value>By 401(k)</value>
				</natureOfOwnership>
			</ownershipNature>
		</nonDerivativeHolding>
		<nonDerivativeHolding>
			<securityTitle>
				<value>Genzyme General common stock (GENZ)</value>
			</securityTitle>
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				</sharesOwnedFollowingTransaction>
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				</natureOfOwnership>
			</ownershipNature>
		</nonDerivativeHolding>
		<nonDerivativeHolding>
			<securityTitle>
				<value>Genzyme General common stock (GENZ)</value>
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				</sharesOwnedFollowingTransaction>
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					<value>I</value>
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					<value>By Trust</value>
				</natureOfOwnership>
			</ownershipNature>
		</nonDerivativeHolding>
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	<derivativeTable>
		<derivativeTransaction>
			<securityTitle>
				<value>Genzyme General NQ stock option (right to buy)</value>
			</securityTitle>
			<conversionOrExercisePrice>
				<value>7.27</value>
			</conversionOrExercisePrice>
			<transactionDate>
				<value>2003-10-20</value>
			</transactionDate>
			<deemedExecutionDate>
			</deemedExecutionDate>
			<transactionCoding>
				<transactionFormType>4</transactionFormType>
				<transactionCode>M</transactionCode>
				<equitySwapInvolved>0</equitySwapInvolved>
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			<transactionAmounts>
				<transactionShares>
					<value>182100</value>
				</transactionShares>
				<transactionPricePerShare>
					<value>0</value>
				</transactionPricePerShare>
				<transactionAcquiredDisposedCode>
					<value>D</value>
				</transactionAcquiredDisposedCode>
			</transactionAmounts>
			<exerciseDate>
				<value>2003-06-30</value>
			</exerciseDate>
			<expirationDate>
				<value>2003-12-08</value>
			</expirationDate>
			<underlyingSecurity>
				<underlyingSecurityTitle>
					<value>Genzyme General common stock (GENZ)</value>
				</underlyingSecurityTitle>
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					<value>182100</value>
				</underlyingSecurityShares>
			</underlyingSecurity>
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					<value>117900</value>
				</sharesOwnedFollowingTransaction>
			</postTransactionAmounts>
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				<directOrIndirectOwnership>
					<value>D</value>
				</directOrIndirectOwnership>
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					<value/>
				</natureOfOwnership>
			</ownershipNature>
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		<derivativeTransaction>
			<securityTitle>
				<value>Genzyme General NQ stock option (right to buy)</value>
			</securityTitle>
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				<value>7.27</value>
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			</transactionDate>
			<deemedExecutionDate>
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				<transactionCode>M</transactionCode>
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					<value>0</value>
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	<footnotes>
		<footnote id="F1">The exercise of this stock option included a distribution of an additional 74 shares of Genzyme common stock.  These stock options were entitled to receive a distribution of shares of Tissue Repair common stock that was paid on July 22, 1997 to Genzyme General Division stockholders at a rate of 0.015.  In connection with the formation of Genzyme Biosurgery in December 2000, shares of Genzyme Tissue Repair were converted into shares of Genzyme Biosurgery at a rate of 0.3352.  In connection with the exchange of Genzyme Biosurgery stock into Genzyme General stock on June 30, 2003, distributions of the Genzyme Biosurgery stock are exchanged into Genzyme General stock at a rate of 0.04945.</footnote>
	</footnotes>
	<remarks>
	</remarks>
	<ownerSignature>
		<signatureName>By: Susan P. Cogswell, Attorney-in-Fact</signatureName>
		<signatureDate>2003-10-22</signatureDate>
	</ownerSignature>
</ownershipDocument>

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</SEC-DOCUMENT>
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