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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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<SEC-DOCUMENT>0000732485-03-000028.txt : 20030709
<SEC-HEADER>0000732485-03-000028.hdr.sgml : 20030709
<ACCEPTANCE-DATETIME>20030709104418
ACCESSION NUMBER:		0000732485-03-000028
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20030630
FILED AS OF DATE:		20030709

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			GENZYME CORP
		CENTRAL INDEX KEY:			0000732485
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				061047163
		STATE OF INCORPORATION:			MA
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		ONE KENDALL SQ
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02139
		BUSINESS PHONE:		6172527500

	MAIL ADDRESS:	
		STREET 1:		ONE KENDALL SQUARE
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02139

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			WIRTH PETER
		CENTRAL INDEX KEY:			0001021041
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		STATE OF INCORPORATION:			MA
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-14680
		FILM NUMBER:		03779382

	BUSINESS ADDRESS:	
		STREET 1:		C/O GENZYME CORP
		STREET 2:		ONE KENDALL SQ
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02139
		BUSINESS PHONE:		6172527500

	MAIL ADDRESS:	
		STREET 1:		ONE KENDALL SQUARE
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02139
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>wir58.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>
    <schemaVersion>X0101</schemaVersion>

    <documentType>4</documentType>
	<periodOfReport>2003-06-30</periodOfReport>
	<notSubjectToSection16>0</notSubjectToSection16>
    <issuer>
        <issuerCik>0000732485</issuerCik>
        <issuerName>GENZYME CORP</issuerName>
        <issuerTradingSymbol>GENZ</issuerTradingSymbol>
	</issuer>
	<reportingOwner>
		<reportingOwnerId>
            <rptOwnerCik>0001021041</rptOwnerCik>
            <rptOwnerName>WIRTH PETER</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>  </rptOwnerStreet1>
            <rptOwnerStreet2>  </rptOwnerStreet2>
            <rptOwnerCity>  </rptOwnerCity>
            <rptOwnerState>  </rptOwnerState>
            <rptOwnerZipCode>  </rptOwnerZipCode>
        </reportingOwnerAddress>
            <reportingOwnerRelationship>
			<isDirector>0</isDirector>
			<isOfficer>1</isOfficer>
			<isTenPercentOwner>0</isTenPercentOwner>
			<isOther>0</isOther>
			<officerTitle>Executive Vice President</officerTitle>
		</reportingOwnerRelationship>
	</reportingOwner>
	<derivativeSecurity>
		<securityTitle>
			<value>Biosurgery ISO stock option (right to buy)</value>
		</securityTitle>
		<conversionOrExercisePrice>
			<value>52.21</value>
		</conversionOrExercisePrice>
		<transactionDate>
			<value>2003-06-30</value>
		</transactionDate>
		<transactionCoding>
			<transactionFormType>4</transactionFormType>
			<transactionCode>J</transactionCode>
			<equitySwapInvolved>0</equitySwapInvolved>
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		<transactionAmounts>
			<transactionShares>
				<value>4190</value>
				<footnoteId id="F1"/>
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			<transactionValue>
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			<transactionAcquiredDisposedCode>
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		<exerciseDate>
			<value>1995-12-15</value>
			<footnoteId id="F2"/>
		</exerciseDate>
		<expirationDate>
			<value>2006-01-02</value>
		</expirationDate>
		<underlyingSecurity>
			<underlyingSecurityTitle>
				<value>Genzyme Biosurgery common stock (GZBX)</value>
			</underlyingSecurityTitle>
			<underlyingSecurityShares>
				<value>4190</value>
			</underlyingSecurityShares>
		</underlyingSecurity>
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			<natureOfOwnership>
				<value/>
			</natureOfOwnership>
		</ownershipNature>
	</derivativeSecurity>
	<derivativeSecurity>
		<securityTitle>
			<value>Biosurgery NQ stock option (right to buy)</value>
		</securityTitle>
		<conversionOrExercisePrice>
			<value>52.21</value>
		</conversionOrExercisePrice>
		<transactionDate>
			<value>2003-06-30</value>
		</transactionDate>
		<transactionCoding>
			<transactionFormType>4</transactionFormType>
			<transactionCode>J</transactionCode>
			<equitySwapInvolved>0</equitySwapInvolved>
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		<transactionAmounts>
			<transactionShares>
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				<footnoteId id="F1"/>
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			<transactionValue>
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			<transactionAcquiredDisposedCode>
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		<exerciseDate>
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		</exerciseDate>
		<expirationDate>
			<value>2005-12-15</value>
		</expirationDate>
		<underlyingSecurity>
			<underlyingSecurityTitle>
				<value>Genzyme Biosurgery common stock (GZBX)</value>
			</underlyingSecurityTitle>
			<underlyingSecurityShares>
				<value>7448</value>
			</underlyingSecurityShares>
		</underlyingSecurity>
		<postTransactionAmounts>
			<sharesOwnedFollowingTransaction>
				<value>0</value>
			</sharesOwnedFollowingTransaction>
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		<ownershipNature>
			<directOrIndirectOwnership>
				<value>D</value>
			</directOrIndirectOwnership>
			<natureOfOwnership>
				<value/>
			</natureOfOwnership>
		</ownershipNature>
	</derivativeSecurity>
	<derivativeSecurity>
		<securityTitle>
			<value>Genzyme General ISO stock option (right to buy)</value>
		</securityTitle>
		<conversionOrExercisePrice>
			<value>0.00</value>
			<footnoteId id="F3"/>
		</conversionOrExercisePrice>
		<transactionDate>
			<value>2003-06-30</value>
		</transactionDate>
		<transactionCoding>
			<transactionFormType>4</transactionFormType>
			<transactionCode>J</transactionCode>
			<equitySwapInvolved>0</equitySwapInvolved>
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		<transactionAmounts>
			<transactionShares>
				<value>207</value>
				<footnoteId id="F1"/>
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			<transactionValue>
				<value>0</value>
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			<transactionAcquiredDisposedCode>
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		<exerciseDate>
			<value>1995-12-15</value>
			<footnoteId id="F2"/>
		</exerciseDate>
		<expirationDate>
			<value>2006-01-02</value>
		</expirationDate>
		<underlyingSecurity>
			<underlyingSecurityTitle>
				<value>Genzyme General common stock (GENZ)</value>
			</underlyingSecurityTitle>
			<underlyingSecurityShares>
				<value>207</value>
			</underlyingSecurityShares>
		</underlyingSecurity>
		<postTransactionAmounts>
			<sharesOwnedFollowingTransaction>
				<value>207</value>
			</sharesOwnedFollowingTransaction>
		</postTransactionAmounts>
		<ownershipNature>
			<directOrIndirectOwnership>
				<value>D</value>
			</directOrIndirectOwnership>
			<natureOfOwnership>
				<value/>
			</natureOfOwnership>
		</ownershipNature>
	</derivativeSecurity>
	<derivativeSecurity>
		<securityTitle>
			<value>Genzyme General NQ stock option (right to buy)</value>
		</securityTitle>
		<conversionOrExercisePrice>
			<value>0.00</value>
			<footnoteId id="F3"/>
		</conversionOrExercisePrice>
		<transactionDate>
			<value>2003-06-30</value>
		</transactionDate>
		<transactionCoding>
			<transactionFormType>4</transactionFormType>
			<transactionCode>J</transactionCode>
			<equitySwapInvolved>0</equitySwapInvolved>
		</transactionCoding>
		<transactionAmounts>
			<transactionShares>
				<value>368</value>
				<footnoteId id="F1"/>
			</transactionShares>
			<transactionValue>
				<value>0</value>
			</transactionValue>
			<transactionAcquiredDisposedCode>
				<value>A</value>
			</transactionAcquiredDisposedCode>
		</transactionAmounts>
		<exerciseDate>
			<value>2005-06-30</value>
		</exerciseDate>
		<expirationDate>
			<value>2005-12-15</value>
		</expirationDate>
		<underlyingSecurity>
			<underlyingSecurityTitle>
				<value>Genzyme General common stock (GENZ)</value>
			</underlyingSecurityTitle>
			<underlyingSecurityShares>
				<value>368</value>
			</underlyingSecurityShares>
		</underlyingSecurity>
		<postTransactionAmounts>
			<sharesOwnedFollowingTransaction>
				<value>368</value>
			</sharesOwnedFollowingTransaction>
		</postTransactionAmounts>
		<ownershipNature>
			<directOrIndirectOwnership>
				<value>D</value>
			</directOrIndirectOwnership>
			<natureOfOwnership>
				<value/>
			</natureOfOwnership>
		</ownershipNature>
	</derivativeSecurity>
	<footnotes>
		<footnote id="F1">On June 30, 2003 in relation to the elimination of Genzyme's tracking stock structure, all stock options of Genzyme Biosurgery and Genzyme Molecular were exchanged for stock options of Genzyme General.  The exchange ratio was based on the closing prices of all three stocks on 6/30/03.  Genzyme Biosurgery options were exchanged at a rate of .04945 and Genzyme Molecular Oncology options were exchanged at a rate of .05614.</footnote>
		<footnote id="F2">Options vest in 20% annual increments beginning on the original date of grant.</footnote>
		<footnote id="F3">These options have a converted exercise price of $1,055.82 per share.</footnote>
	</footnotes>
	<ownerSignature>
		<signatureName>By: Susan P. Cogswell, Attorney-in-Fact</signatureName>
		<signatureDate>2003-07-02</signatureDate>
	</ownerSignature>
</ownershipDocument>

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</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----