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Stockholders' Equity (Tables)
 9 Months Ended
Sep. 30, 2019
Stock-Based Compensation Expense The following table presents stock-based compensation expense in the Company’s consolidated statements of comprehensive income (loss):
                                 
 
Three Months Ended
September 30,
   
Nine Months Ended
September 30,
 
 
2019
 
  
2018
 
  
2019
 
  
2018
 
 
(Amounts in thousands)
 
Cost of product revenue
  $
375
 
 
 
 
 
 
 
 $
277
 
 
 
 
 
 
 
 $
992
 
 
 
 
 
 
 
 $
777
 
Research and development
   
351
     
253
     
992
     
650
 
Selling, general and administrative
   
2,449
     
2,249
     
7,475
     
6,245
 
                                 
Total stock-based compensation
  $
 
 
3,175
    $
 
 
2,779
    $
9,459
    $
7,672
 
                                 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Estimated Weighted Average Assumptions
Information regarding option activity for the nine months ended September 30, 2019 under the Plans is summarized below:
                                 
 
Shares
 
  
Weighted
average
exercise
price
 
  
Weighted-
Average
Remaining
Contractual
Term
(in Years)
 
  
Aggregate
Intrinsic Value
(in Thousands)
 
Options outstanding at December 31, 2018
   
998,226
    $
27.54
     
     
 
Granted
   
44,996
    $
61.98
     
     
 
Exercised
   
(83,306
 )   $
12.70
     
     
 
Forfeited/expired/cancelled
   
—  
     $
—  
      
     
 
                                 
Options outstanding at September 30, 2019
   
959,916
    $
30.44
     
6.93
    $
44,396
 
                                 
Options exercisable at September 30, 2019
   
503,934
    $
24.18
     
5.64
    $
26,464
 
                                 
Vested and expected to vest at September 30, 2019
(1)
    
923,962
     
     
6.87
    $
42,961
 
                                 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
(1) Represents the number of vested options as of September 30, 2019 plus the number of unvested options expected to vest as of September 30, 2019 based on the unvested outstanding options at September 30, 2019 adjusted for estimated forfeiture rates of 8% for awards granted to
non-executive
level employees and 3% for awards granted to executive level employees.
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Summary of Restricted Stock Unit Activity
Information regarding RSU activity for the nine months ended September 30, 2019 under the Plans is summarized below:
                         
 
Shares
 
  
Weighted-
Average
Remaining
Contractual
Term
(in Years)
 
  
Aggregate
Intrinsic Value
(in Thousands)
 
Unvested at December 31, 2018
   
707,413
     
     
 
Awarded
   
297,086
     
     
 
Vested
   
(228,103
 )    
     
 
Forfeited/expired/cancelled
   
(36,183
 )    
     
 
                         
Unvested at September 30, 2019
   
740,213
     
3.85
    $
56,767