Stockholders' Equity (Tables)

9 Months Ended

Sep. 30, 2022

Stock-Based Compensation Expense

The following table presents stock-based compensation expense in the Company’s consolidated statements of comprehensive income:

	Three Months Ended September 30,				Nine Months Ended September 30,
	2022		2021		2022		2021
	(Amounts in thousands)
Cost of product revenue	$	610	$	489	$	1,847	$	1,444
Research and development		534		698		1,955		2,209
Selling, general and administrative		5,010		5,605		17,252		16,823
Total stock-based compensation	$	6,154	$	6,792	$	21,054	$	20,476

Summary of Option Activity

Information regarding option activity for the nine months ended September 30, 2022 under the Plans is summarized below:

	Shares			Weighted average exercise price		Weighted- Average Remaining Contractual Term (in Years)		Aggregate Intrinsic Value (in Thousands)
Options outstanding at December 31, 2021		625,107		$	54.15		6.29	$	131,707
Granted		47,838		$	180.82
Exercised		(61,006	)	$	45.64
Forfeited/expired/cancelled		(8,000	)	$	193.86
Options outstanding at September 30, 2022		603,939		$	63.19		5.89	$	75,626
Options exercisable at September 30, 2022		341,192		$	46.89		5.28	$	48,042
Vested and expected to vest at September 30, 2022(1)		589,320					5.88	$	73,832

(1)Represents the number of vested options as of September 30, 2022 plus the number of unvested options expected to vest as of September 30, 2022 based on the unvested outstanding options at September 30, 2022 adjusted for estimated forfeiture rates of 8% for awards granted to non-executive level employees and 3% for awards granted to executive level employees.

Summary of Restricted Stock Unit Activity

Information regarding stock unit activity, which includes activity for RSUs and performance stock units, for the nine months ended September 30, 2022 under the Plans is summarized below:

	Shares			Weighted- Average Remaining Contractual Term (in Years)		Aggregate Intrinsic Value (in Thousands)
Unvested at December 31, 2021		606,685			3.07	$	160,674
Awarded		159,117
Vested		(190,152	)
Forfeited/expired/cancelled		(43,394	)
Unvested at September 30, 2022		532,256			2.93	$	99,590
Vested and expected to vest at September 30, 2022(1)		516,326			2.48	$	96,610

Represents the number of vested stock units as of September 30, 2022 plus the number of unvested stock units expected to vest as of September 30, 2022 based on the unvested outstanding stock units at September 30, 2022 adjusted for estimated forfeiture rates of 8% for awards granted to non-executive level employees and 3% for awards granted to executive level employees.