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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
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 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 NMg14IYiTC++9b1HS+/FHM2BbQU66P6s3ysL5PNL41PRkRt+pZg52+0zxb+XgqfW
 cT2LfemfACfzPje/Oio5/g==

<SEC-DOCUMENT>0001209191-03-012096.txt : 20030716
<SEC-HEADER>0001209191-03-012096.hdr.sgml : 20030716
<ACCEPTANCE-DATETIME>20030716122303
ACCESSION NUMBER:		0001209191-03-012096
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20030714
FILED AS OF DATE:		20030716

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			GRANNER DARYL K
		CENTRAL INDEX KEY:			0001238974

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-15190
		FILM NUMBER:		03788721

	MAIL ADDRESS:	
		STREET 1:		OSI PHARMACEUTICALS INC
		STREET 2:		58 S SERVICE RD STE 110
		CITY:			MELVILLE
		STATE:			NY
		ZIP:			11747

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			OSI PHARMACEUTICALS INC
		CENTRAL INDEX KEY:			0000729922
		STANDARD INDUSTRIAL CLASSIFICATION:	IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES [2835]
		IRS NUMBER:				133159796
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			0930

	BUSINESS ADDRESS:	
		STREET 1:		58 SOUTH SERVICE RD.
		STREET 2:		SUITE 110
		CITY:			MELVILLE
		STATE:			NY
		ZIP:			11747
		BUSINESS PHONE:		631-962-2000

	MAIL ADDRESS:	
		STREET 1:		58 SOUTH SERVICE RD.
		STREET 2:		SUITE 110
		CITY:			MELVILLE
		STATE:			NY
		ZIP:			11747

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ONCOGENE SCIENCE INC
		DATE OF NAME CHANGE:	19920703
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>doc4.xml
<DESCRIPTION>FORM 4 SUBMISSION
<TEXT>
<XML>
<?xml version="1.0"?><ownershipDocument><schemaVersion>X0101</schemaVersion>    <documentType>4</documentType><periodOfReport>2003-07-14</periodOfReport><notSubjectToSection16>0</notSubjectToSection16><issuer><issuerCik>0000729922</issuerCik><issuerName>OSI PHARMACEUTICALS INC</issuerName>        <issuerTradingSymbol>OSIP</issuerTradingSymbol></issuer><reportingOwner><reportingOwnerId><rptOwnerCik>0001238974</rptOwnerCik><rptOwnerName>GRANNER DARYL K</rptOwnerName></reportingOwnerId><reportingOwnerAddress><rptOwnerStreet1>  </rptOwnerStreet1><rptOwnerStreet2>  </rptOwnerStreet2><rptOwnerCity>  </rptOwnerCity><rptOwnerState>  </rptOwnerState><rptOwnerZipCode>  </rptOwnerZipCode></reportingOwnerAddress><reportingOwnerRelationship><isDirector>1</isDirector><isOfficer>0</isOfficer><isTenPercentOwner>0</isTenPercentOwner><isOther>0</isOther></reportingOwnerRelationship></reportingOwner><nonDerivativeSecurity><securityTitle><value>Common Stock</value></securityTitle><transactionDate><value>2003-07-14</value></tran
sactionDate><transactionCoding><transactionFormType>4</transactionFormType><transactionCode>M</transactionCode><equitySwapInvolved>0</equitySwapInvolved></transactionCoding><transactionTimeliness><value></value></transactionTimeliness><transactionAmounts><transactionShares><value>5000</value></transactionShares><transactionValue><value>5.25</value></transactionValue><transactionAcquiredDisposedCode><value>A</value></transactionAcquiredDisposedCode></transactionAmounts><postTransactionAmounts><sharesOwnedFollowingTransaction><value>9993</value></sharesOwnedFollowingTransaction></postTransactionAmounts><ownershipNature><directOrIndirectOwnership><value>D</value></directOrIndirectOwnership></ownershipNature></nonDerivativeSecurity><nonDerivativeSecurity><securityTitle><value>Common Stock</value></securityTitle><transactionDate><value>2003-07-14</value></transactionDate><transactionCoding><transactionFormType>4</transactionFormType><transactionCode>S</transactionCode><equitySwapInvolved>0</equitySwapInvolved></t
ransactionCoding><transactionTimeliness><value></value></transactionTimeliness><transactionAmounts><transactionShares><value>5000</value></transactionShares><transactionValue><value>35</value></transactionValue><transactionAcquiredDisposedCode><value>D</value></transactionAcquiredDisposedCode></transactionAmounts><postTransactionAmounts><sharesOwnedFollowingTransaction><value>4993</value></sharesOwnedFollowingTransaction></postTransactionAmounts><ownershipNature><directOrIndirectOwnership><value>D</value></directOrIndirectOwnership></ownershipNature></nonDerivativeSecurity><derivativeSecurity><securityTitle><value>Stock Option (Right to Buy)</value></securityTitle><conversionOrExercisePrice><value>5.25</value></conversionOrExercisePrice><transactionDate><value>2003-07-14</value></transactionDate><transactionCoding><transactionFormType>4</transactionFormType><transactionCode>M</transactionCode><equitySwapInvolved>0</equitySwapInvolved></transactionCoding><transactionTimeliness><value></value></transactionTime
liness><transactionAmounts><transactionShares><value>5000</value></transactionShares><transactionValue><value>0</value><footnoteId id="F2" /></transactionValue><transactionAcquiredDisposedCode><value>D</value></transactionAcquiredDisposedCode></transactionAmounts><exerciseDate><value>1999-06-18</value><footnoteId id="F1" /></exerciseDate><expirationDate><value>2008-06-17</value><footnoteId id="F2" /></expirationDate><underlyingSecurity><underlyingSecurityTitle><value>Common Stock</value></underlyingSecurityTitle><underlyingSecurityShares><value>5000</value></underlyingSecurityShares></underlyingSecurity><postTransactionAmounts><sharesOwnedFollowingTransaction><value>5000</value></sharesOwnedFollowingTransaction></postTransactionAmounts><ownershipNature><directOrIndirectOwnership><value>D</value><footnoteId id="F3" /></directOrIndirectOwnership></ownershipNature></derivativeSecurity><footnotes><footnote id="F1">One third of the stock option became exercisable on 6/18/1999 and the remainder vested ratably on a
 monthly basis over the succeeding 24 months.</footnote><footnote id="F2">The stock option was granted pursuant to the Issuer's 1997 Incentive and Non-Qualified Stock Option Plan and is exempt under Rule 16b-3.</footnote><footnote id="F3">Includes only options with the same termination date.</footnote></footnotes><ownerSignature><signatureName>Robert L. Van Nostrand by Power of Attorney</signatureName><signatureDate>2003-07-16</signatureDate></ownerSignature></ownershipDocument>

</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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