UNITED STATES
                             SECURITIES AND EXCHANGE COMMISSION
                                   Washington, D.C. 20549


                                        SCHEDULE 13G
                         Under the Securities Exchange Act of 1934
                                     (Amendment No. 1)*

                                Alexion Pharmaceuticals

                                    (Name of Issuer)

                                      Common Stock

                             (Title of Class of Securities)

                                       015351109

                                     (CUSIP Number)
                                        12/31/02

                (Date of Event Which Requires Filing of this Statement)



Check the appropriate box to designate the rule pursuant to which this Schedule is filed:
[X]      Rule 13d-1(b)
[  ]     Rule 13d-1(c)
[  ]     Rule 13d-1(d)

*The remainder of this cover page shall be filled out for a reporting person's initial
filing on this form with respect to the subject class of securities, and for any subsequent
amendment containing information which would alter the disclosures provided in a prior
cover page.

The information required in the remainder of this cover page shall not be deemed to be
"filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 ("Act") or
otherwise subject to the liabilities of that section of the Act but shall be subject to all
other provisions of the Act (however, see the Notes).












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  CUSIP No.: 015351109

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       1.       Names of Reporting Persons
                IRS Identification No:

                OppenheimerFunds, Inc.
                IRS No. 13-2527171
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       2.        Check the Appropriate Box if a Member of a Group (See Instructions):
                 Joint Filing
                (a)
                (b)
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       3.       SEC Use Only
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       4.       Citizenship or Place of Organization:
                Colorado
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   Number of
     Shares     5.    Sole Voting Power:
  Beneficially       0
    Owned by
      Each
   Reporting
  Person With
 ------------------------------------------------------------------------------------------
 ------------------------------------------------------------------------------------------

                6.    Shared Voting Power:
                     0
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 ------------------------------------------------------------------------------------------

                7.    Sole Dispositive Power:
                     0
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 ------------------------------------------------------------------------------------------

                8.    Shared Dispositive Power:
                     2,500,000
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       9.       Aggregate Amount Beneficially Owned by Each Reporting Person:
                2,500,000 (beneficial ownership disclaimed pursuant to Rule 13d-4 of the
                Exchange Act of 1934)
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 ------------------------------------------------------------------------------------------

      10.       Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See
                Instructions)
                [  ]
 ------------------------------------------------------------------------------------------
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      11.       Percent of Class Represented by Amount in Row (11):
                13.73%
 ------------------------------------------------------------------------------------------
 ------------------------------------------------------------------------------------------

      12.       Type of Reporting Person (See Instructions):
                IA
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 ------------------------------------------------------------------------------------------
  CUSIP No.: 015351109

 ------------------------------------------------------------------------------------------
 ------------------------------------------------------------------------------------------

       1.       Names of Reporting Persons
                IRS Identification No: 93-1036175

                Oppenheimer Global Growth & Income Fund
 ------------------------------------------------------------------------------------------
 ------------------------------------------------------------------------------------------

       2.        Check the Appropriate Box if a Member of a Group (See Instructions):
                 Joint Filing
                (a)
                (b)
 ------------------------------------------------------------------------------------------
 ------------------------------------------------------------------------------------------

       3.       SEC Use Only
 ------------------------------------------------------------------------------------------
 ------------------------------------------------------------------------------------------

       4.       Citizenship or Place of Organization:
                Massachusetts
 ------------------------------------------------------------------------------------------
 ------------------------------------------------------------------------------------------
   Number of
     Shares     5.      Sole Voting Power:
  Beneficially       2,500,000
    Owned by
      Each
   Reporting
  Person With
 ------------------------------------------------------------------------------------------
 ------------------------------------------------------------------------------------------

                6.       Shared Voting Power:
                     0
 ------------------------------------------------------------------------------------------
 ------------------------------------------------------------------------------------------

                7.    Sole Dispositive Power:
                     0
 ------------------------------------------------------------------------------------------
 ------------------------------------------------------------------------------------------

                8.    Shared Dispositive Power:
                     2,500,000
 ------------------------------------------------------------------------------------------
 ------------------------------------------------------------------------------------------

       9.       Aggregate Amount Beneficially Owned by Each Reporting Person:
                2,500,000
 ------------------------------------------------------------------------------------------
 ------------------------------------------------------------------------------------------

      10.       Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See
                Instructions)
                [  ]
 ------------------------------------------------------------------------------------------
 ------------------------------------------------------------------------------------------

      11.       Percent of Class Represented by Amount in Row (11):
                13.73%
 ------------------------------------------------------------------------------------------
 ------------------------------------------------------------------------------------------

      12.       Type of Reporting Person (See Instructions):
                IV
 ------------------------------------------------------------------------------------------


 ---------------------------------------------------------------------------------------
 Item:
 ---------------------------------------------------------------------------------------






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     1(a)     Name of Issuer:
              Alexion Pharmaceuticals
 ---------------------------------------------------------------------------------------
 ---------------------------------------------------------------------------------------

     1(b)     Address of Issuer's Principal Executive Offices:
              352 Knotter Drive
              Cheshire, CT  06410
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     2(a)     Name of Person Filing:
              (i)   OppenheimerFunds, Inc.
              (ii)  Oppenheimer Global Growth & Income Fund
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     2(b)     Address of Principal Business Office or, if none, Residence:
              (i)  498 Seventh Avenue
                    New York, NY 10018
              (ii)  6803 S. Tucson Way
                    Englewood, CO  80112

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     2(c)     Citizenship:
              (i)  Colorado
              (ii) Massachusetts
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     2(d)     Title of Class of Securities:
              Common Stock
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     2(e)     CUSIP Number:
              015351109
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      3       If this statement is filed pursuant toss.240.13d-1(b) orss.240.13d-2(b) or
              (c), check whether the person filing is a:
              [X] An investment adviser in accordance withss.240.13d-1(b)(1)(ii)(E)
              [X]  Investment company registered under section 8 of the Investment
              Company Act of 1940
                      (15 U.S.C. 80a-8)
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     4(a)     Amount beneficially owned:
              (i)  2,500,000 (beneficial ownership disclaimed pursuant to Rule 13d-4
              of the Exchange Act of 1934)
              (ii) 2,500,000
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     4(b)     Percent of class:
              (i)  13.73%  (reflects ownership reported in 4(b)(ii) below)
              (ii) 13.73%
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      4(c)    Number of shares as to which the person has:

         (i)  Sole power to vote or to direct the vote:
              (a)   0
              (b)   2,500,000
         (ii) Shared power to vote or to direct the vote:
              (a)   0
              (b)   0
       (iii)  Sole power to dispose or to direct the disposition of:
              (a)   0
              (b)   0
        (iv)  Shared power to dispose or to direct the disposition of:
              (a)   2,500,000
              (b)     2,500,000
 ---------------------------------------------------------------------------------------
 ---------------------------------------------------------------------------------------

      5.      Ownership of Five Percent or Less of a Class: [  ]
 ---------------------------------------------------------------------------------------
 ---------------------------------------------------------------------------------------

      6.      Ownership of More than Five Percent on Behalf of Another Person.:
              See Exhibit A hereto.
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 ---------------------------------------------------------------------------------------

      7.      Identification and Classification of the Subsidiary Which Acquired the
              Security Being Reported on By the Parent Holding Company:
              N/A
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 ---------------------------------------------------------------------------------------

      8.      Identification and Classification of Members of the Group:
              N/A
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      9.      Notice of Dissolution of Group:
              N/A
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     10.      Certification:
              By signing below I certify that, to the best of my knowledge and belief,
              the securities referred to above were acquired and are held in the
              ordinary course of business and were not acquired and are not held for
              the purpose of or with the effect of changing or influencing the control
              of the issuer of the securities and were not acquired and are not held
              in connection with or as a participant in any transaction having that
              purpose or effect.

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                                         SIGNATURE
After reasonable inquiry and to the best of my knowledge and belief, I certify that the
information set forth in this statement is true, complete and correct.

                                                             02/12/03
                                                            Date

                                                      /s/ Philip T. Masterson
                                                            Signature

                                                  Philip T. Masterson, Vice President
                                                            Name/Title






                                         EXHIBIT A

      The respective Boards of Directors or Trustees of the registered investment companies
managed by OppenheimerFunds, Inc. ("OFI") that own shares of the issuer can direct the
disposition of dividends received by such funds and can dispose of such securities.
Additionally, OFI shares the power to dispose of such securities with the Board of
Directors or Trustees of such funds; however, the Boards of Directors or Trustees of such
funds have delegated this responsibility to OFI as the funds' investment advisor under the
respective investment advisory agreements. OFI has an interest relating to five (5%)
percent or more of such securities as disclosed on Page 2 hereof, by virtue of the interest
of five percent (5%) or more of such securities by Oppenheimer Global Growth & Income Fund
as disclosed on pages 3 and 4 hereof. OFI disclaims ownership of such securities, except as
expressly stated herein.






                                         EXHIBIT B

      The undersigned investment company hereby acknowledges and agrees that a report on
Schedule 13G filed by OppenheimerFunds, Inc. on or about the date hereof, relating to the
common stock of Alexion Pharmaceuticals is filed on behalf of the undersigned.

Dated:  February 12, 2003

                                                Oppenheimer Global Growth & Income Fund



                                                By:   /s/ Philip T. Masterson

                                                      Philip T. Masterson
                                                      Assistant Secretary