UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

Form 13F-NT

FORM 13F COVER PAGE

Report for the Calendar Year or Quarter Ended: March 31, 2006

Check here if Amendment [  ];          Amendment Number:______
This Amendment (Check only one.): [  ] is a restatement.
                                  [  ] adds new holdings entries.
Institutional Investment Manager Filing this Report:


Name:    MERRILL LYNCH, PIERCE, FENNER AND SMITH INC.
Address: 4 World Financial Center
         New York, NY 10080

13F File Number: 028-00962

The institutional investment manager filing this report and the person by
whom it is signed hereby represent that the person signing the report is
authorized to submit it, that all information contained herein is true,
correct and complete, and that it is understood that all required items,
statements, schedules, and tables, are considered integral parts of this
form.

Person Signing this Report on Behalf of Reporting Manager:

Name:  Michael LamMaina
Title: Assistant Secretary
Phone: (212) 670-0426

Signature, Place and Date of Signing:


__________________________
/s/ Michael LaMaina
New York, NY
May 08, 2006

Report Type (Check only one.):

[ ]      13F HOLDINGS REPORT.

[X]      13F NOTICE.

[ ]      13F COMBINATION REPORT.


List of Other Managers Reporting for this Manager

Form 13F File Number    Name
- --------------------    --------------------------
     028-03554          MERRILL LYNCH AND CO., INC.