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Stockholders' Deficit (Tables)
3 Months Ended
Mar. 31, 2021
Stockholders' Equity Note [Abstract]  
Schedule of stock-based compensation expense
   2021   2020 
Research and development  $   $3 
General and administrative   17    16 
Director   7    3 
Total stock-based compensation  $24   $22 
Schedule of option activity under the Company's plans
   2021   2020 
Options  Shares   Weighted
Average
Exercise
Price per
share
   Weighted
Average
Remaining
Contractual
Term
(Years)
   Aggregate
Intrinsic
Value
   Shares   Weighted
Average
Exercise
Price per
share
   Weighted
Average
Remaining
Contractual
Term
(Years)
   Aggregate
Intrinsic
Value
 
Outstanding at January 1   1,338   $0.87       $  –    1,077   $1.59                   – 
Granted      $               $         
Canceled      $              (10)  $56.10           
Outstanding at March 31   1,338   $0.87    4.35   $    1,067   $1.07    4.76     
Vested and expected to vest at March 31   1,320   $0.88    3.99   $    1,062   $1.59    4.92   $ 
Exercisable at March 31   1,018   $0.97    3.86   $    736   $1.25    4.60   $ 
Schedule of significant ranges of outstanding and exercisable options
   Options Outstanding   Options Exercisable 
Range of Exercise Prices  Number
Outstanding
  

Weighted
Average
Remaining
Contractual
Term 

(in years)

   Weighted
Average
Exercise
Price
   Number
Outstanding
  

Weighted
Average
Exercise

Price

 
$0.01 - $0.50   930    4.39   $0.50    675   $0.50 
$0.51 - $1.00   393    4.36   $0.78    328   $0.78 
$1.01 - $25.00   2    1.33   $15.94    2   $15.94 
$25.01 – $625.00   13    0.77   $28.12    13   $28.12 
Total   1,338    4.34   $0.87    1,018   $0.97 
Schedule of the company's non-vested shares
Non-vested Shares  Shares   Weighted
Average
Grant-Date
Fair Value
 
Non-vested at January 1, 2021   381   $0.57 
Vested   (60)  $0.57 
Non-vested at March 31, 2020   321   $0.56 
Schedule of warrant activity
   2021   2020 
   Shares   Weighted
Average
Exercise
Price
   Shares   Weighted
Average
Exercise
Price
 
Outstanding at beginning of period   3,001   $1.37    2536   $1.52 
Issued        $     30   $0.50 
Outstanding at end of period   3,001   $1.37    2,566   $1.51 
Exercisable at end of period   3,001   $1.37    2,566   $1.51 
Schedule of warrants outstanding and exercisable
Number of Shares   Weighted Average
Remaining Life
   Weighted Average
Exercise Price per
share
 
          
 1,551    0.13   $2.18 
 1,450    1.36   $0.50 
 3,001    0.73   $1.37