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Stockholders' Equity (Deficit) (Tables)
6 Months Ended
Jun. 30, 2019
Equity [Abstract]  
Schedule of allocation of stock-based compensation expense
   Three Months Ended
June 30,
   Six Months Ended
June 30,
 
   2019   2018   2019   2018 
Research and development  $8   $23   $17   $54 
General and administrative  $32   $1   $73   $14 
Director and consultant options  $8   $2   $17   $7 
Total stock-based compensation expense  $48   $26   $107   $75 
Schedule of option activity under the Company's plans
   2019   2018 
Options  Shares   Weighted
Average
Exercise Price
Per Share
   Weighted
Average
Remaining
Contractual
Life (Years)
   Aggregate
Intrinsic
Value
   Shares   Weighted
Average
Exercise Price
Per Share
   Weighted
Average
Remaining
Contractual
Life (Years)
   Aggregate
Intrinsic
Value
 
Outstanding at January 1,   1,037   $1.65       $    736   $3.65        $  − 
Granted   40   $0.50    

   $       $        $

 
Forfeited or expired      $    

   $    (10)  $79.80        $

 
Outstanding at June 30   1,077   $1.61    5.50   $    726   $2.56    5.94   $

 
Vested and expected to vest at June 30   1,070   $1.61    5.50   $    696   $2.69    5.93   $

 
Exercisable at June 30   489   $2.77    5.16   $

    213   $7.50    5.32   $

 
Schedule of significant ranges of outstanding and exercisable options
   Options Outstanding   Options Exercisable 
Range of Exercise Prices  Number Outstanding   Weighted
Average
Remaining Contractual Term
(in years)
   Weighted
Average
Exercise Price
per share
   Number
Outstanding
   Weighted
Average
Exercise Price
per Share
 
$0.01 – $0.50   655    5.27   $0.50    361   $0.50 
$0.51 – $625.00   422    5.85   $3.33    128   $9.20 
Total   1,077    5.50   $1.61    489   $2.77 
Schedule of the company's non-vested shares
Non-vested Shares  Shares   Weighted Average
Grant-Date
Fair Value
per share
 
Non-vested at January 1, 2019   718   $0.54 
Granted   40   $0.50 
Vested   (170)  $0.63 
Non-vested at June 30, 2019   588   $0.64 
Schedule of warrant activity
   2019   2018 
   Shares   Weighted
Average
Exercise Price
Per Share
   Shares   Weighted
Average
Exercise Price
Per Share
 
Outstanding at beginning of period   1,828   $2.08    1,878   $2.46 
Issued   985   $0.50    

   $ 
Expired   

   $

    (39)  $15.63 
Outstanding at end of period   2,813   $1.53    1,839   $1.58 
Exercisable at end of period   2,813   $1.53    1,839   $1.58 
Schedule of warrants outstanding and exercisable
Number of Warrants  Weighted
Average
Remaining
Life (years)
   Weighted
Average
Exercise Price
per share
 
         
1,550   1.91   $2.18 
278   0.26   $1.63 
985   2.64   $0.50 
2,813   2.00   $1.53