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Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($)
$ in Thousands
9 Months Ended
Sep. 30, 2017
Sep. 30, 2016
Cash flows from operating activities:    
Net loss $ (26,789) $ (19,615)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation 212 219
Amortization of debt discount and issuance costs 2,829 3,277
Interest expense added to loan principal 6,884 6,399
Interest expense added to lease liability 718 543
Loss on debt conversion 56
Loss on early extinguishment of debt 3,501 2,250
Compensation charge for stock and share option awards 2,027 974
Changes in operating assets and liabilities:    
(Increase) decrease in accounts receivable (17) 121
Decrease (increase) in prepaid expenses and other 2,866 (3,146)
(Increase) in other assets (214) (214)
(Decrease) increase in accounts payable (53) 350
(Decrease) increase in accrued liabilities (3,493) 2,432
Increase in warrant liabilities 3,747
Net cash used in operating activities (7,726) (6,410)
Cash flows from investing activities:    
Additions to property, plant and equipment (671)
Net cash used in investing activities (671)
Cash flows from financing activities:    
Up-front payment related to lease liability 11,509
Net proceeds from the issuance of long-term debt 57,190 7,600
Debt issuance costs (97)
Principal payments on long-term debt (44,910) (11,399)
Net cash provided by financing activities 12,280 7,613
Net increase in cash and cash equivalents 3,883 1,203
Cash and cash equivalents, beginning of period 12,172 2,690
Cash and cash equivalents, end of period $ 16,055 $ 3,893