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Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($)
$ in Thousands
6 Months Ended
Jun. 30, 2017
Jun. 30, 2016
Cash flows from operating activities:    
Net loss $ (20,797) $ (14,440)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation 143 146
Amortization of debt discount and issuance costs 1,835 2,574
Interest expense added to loan principal 4,534 4,188
Interest expense added to lease liability 471 330
Gain on debt conversion 55
Loss on early extinguishment of debt 3,501 2,250
Compensation charge for stock and share option awards 1,921 759
Changes in operating assets and liabilities:    
(Increase) decrease in accounts receivable (11) 129
Decrease (increase) in prepaid expenses and other 2,875 (22)
Increase in other assets (243) (357)
Increase (decrease) in accounts payable 40 (63)
Increase (decrease) in accrued liabilities 1,464 (315)
(Decrease) in other long-term liabilities (655)
Net cash used in operating activities (4,867) (4,821)
Cash flows from investing activities:    
Additions to property, plant and equipment (161)
Net cash used in investing activities (161)
Cash flows from financing activities:    
Up-front payment related to lease liability 11,509
Net Proceeds from the issuance of long-term debt 57,190 7,600
Debt issuance costs (102)
Principal payments on long-term debt (44,900) (10,958)
Net cash provided by financing activities 12,290 8,049
Net increase in cash and cash equivalents 7,262 3,228
Cash and cash equivalents, beginning of period 12,172 2,690
Cash and cash equivalents, end of period $ 19,434 $ 5,918