Income Taxes (Tables)

12 Months Ended

Dec. 31, 2020

Income Tax Disclosure [Abstract]

Schedule of Components of Pretax Loss from Operations

The components of the pretax loss from operations for the years ended December 31 are as follows (in thousands):

	2020		2019		2018
U.S. Domestic	$	(66,482)	$	(70,452)	$	(67,508)
Foreign	(11,721)		(13,964)		(20,607)
Net loss before income taxes	$	(78,203)	$	(84,416)	$	(88,115)

Schedule of Provision for Income Taxes

The components of the provision for income taxes for the years ended December 31 is presented in the following table:

	2020		2019		2018
Current:
Federal	$	—	$	—	$	—
State	(1)		(8)		(14)
Foreign	(4)		119		(197)
Total (provision) benefit	(5)		111		(211)
Deferred:
Federal	—		—		—
State	—		—		—
Foreign	—		—		—
Total deferred provision	—		—		—
Total (provision) benefit	$	(5)	$	111	$	(211)

Deferred Income Tax Components

Significant components of the Company’s net deferred income taxes for the years ended December 31 are as follows (in thousands):

	2020		2019
Deferred tax assets:
Net operating loss carryforward	$	81,733	$	66,319
General business credit	15,484		11,306
Stock options	13,366		13,217
Operating lease liability	846		908
Property & equipment	206		403
Inventory	588		397
Intangible assets, definite-lived	55		38
Other	284		30
Total deferred tax assets	112,562		92,618
Valuation allowance	(104,585)		(81,946)
Deferred tax assets	$	7,977	$	10,672
Deferred tax liabilities:
Debt amortization	$	(7,229)	$	(9,793)
Right of use asset	$	(748)	$	(879)
Total deferred tax liabilities	$	(7,977)	$	(10,672)
Net deferred taxes	$	—	$	—

Effective Tax Rate

The difference between the U.S. federal statutory income tax rate and the Company’s effective tax rate for years ending December 31 is as follows:

	2020		2019		2018
U.S. federal statutory income tax rate	(21.00)	%	(21.00)	%	(21.00)	%
State taxes, net of federal tax benefit	(4.95)		(3.83)		(3.07)
Permanent and other differences	2.35		(0.25)		(0.26)
Change in tax rates	(0.05)		0.16		(0.41)
Tax rate differential	3.09		3.28		4.92
Unrecognized tax benefits	1.34		0.79		0.81
Nondeductible equity and other compensation	(3.38)		1.12		(0.17)
Credit for increased research activities	(6.29)		(2.80)		(3.12)
Change in valuation allowance	28.89		22.40		22.54
	—	%	(0.13)	%	0.24	%

Uncertain Tax Positions

The Company's uncertain tax positions at December 31 as follows (in thousands):

	2020		2019		2018
Balance at beginning of year	$	3,712	$	2,983	$	2,141
Increases for prior positions	—		7		70
Increases for current year positions	1,154		724		775
Other decreases	—		(2)		(3)
Balance at end of year	$	4,866	$	3,712	$	2,983