STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2016	Sep. 30, 2015	Sep. 30, 2016	Sep. 30, 2015
Revenues:
Product sales	$ 2	$ 76	$ 145	$ 76
Licensing and royalty revenues	22	16	62	49
Total revenues	24	92	207	125
Costs and expenses:
Research and development	7,531	6,499	22,948	19,356
Sales, general and administrative	9,308	4,332	25,983	11,953
Amortization	3	3	8	8
Depreciation	598	465	1,745	1,194
Total costs and expenses	17,440	11,299	50,684	32,511
Loss from operations	(17,416)	(11,207)	(50,477)	(32,386)
Interest expense and other	0	(1)	0	(3)
Foreign currency exchange gain (loss)	(42)	1	(115)	1
Interest and dividend income	159	21	353	53
Total other income	117	21	238	51
Net loss	$ (17,299)	$ (11,186)	$ (50,239)	$ (32,335)
Basic and diluted net loss per share (dollars per share)	$ (0.34)	$ (0.25)	$ (0.98)	$ (0.72)
Weighted average shares outstanding (shares)	51,239	44,727	51,216	44,685
Other comprehensive loss:
Net loss	$ (17,299)	$ (11,186)	$ (50,239)	$ (32,335)
Net unrealized (loss) gain on available-for-sale investments	(70)	(1)	11	(4)
Foreign currency translation adjustment	(8)	(2)	(8)	(2)
Comprehensive loss	$ (17,377)	$ (11,189)	$ (50,236)	$ (32,341)