SECURITIES AND EXCHANGE COMMISSION

                          Washington, D.C. 20549

                               Schedule 13G


                 Under the Securities Exchange Act of 1934
                            (Amendment No.   )*


                     GUILFORD PHARMACEUTICALS INC.
               _______________________________________
                          (Name of Issuer)


                            Common Stock
               _______________________________________
                    (Title of Class of Securities)


                            401829106
               _______________________________________
                          (CUSIP Number)


          Check the following box if a fee is being paid with this 
          statement [    ] .  (A fee is not required only if the filing 
          person: (1) has a previous statement on file reporting beneficial
          ownership of more than five percent of the class of securities
          described in Item 1; and (2) has filed no amendment subsequent
          thereto reporting beneficial ownership of five percent or less of
          such class.)  (See Rule 13d-7.)

          *The remainder of this cover page shall be filled out for a
          reporting person's initial filing on this form with respect to
          the subject class of securities, and for any subsequent amendment
          containing information which would alter the disclosures provided
          in a prior cover page.

          The information required in the remainder of this cover page
          shall not be deemed to be "filed" for the purpose of Section 18
          of the Securities Exchange Act of 1934 ("Act") or otherwise
          subject to the liabilities of that section of the Act but shall
          be subject to all other provisions of the Act (however, see the
          Notes).



CUSIP NO. 401829 10 6           			  13G      			 Page 2 of 4 Pages

         1  Name of Reporting Person
             S.S. or I.R.S. Identification No. of Above Person
            
             SCIOS INC. (formerly Scios Nova Inc.)
             95-3701481

          2  Check the Appropriate Box if a Member of a Group*

             NOT APPLICABLE          (a) ____
 				                                (b) ____

          3  SEC Use Only

             ______________________________

          4  Citizenship or Place of Organization

              DELAWARE
          
          Number of     	 5  Sole Voting Power         			  
          Shares     			     1,450,000     
          Beneficially  	 6  Shared Voting Power            			 
          Owned By Each   		 -0-
          Reporting    	  7  Sole Dispositive Power
          Person          		 1,450,000
          With          		 8 Shared Dispositive Power
                      			    -0-

          9  Aggregate Amount Beneficially Owned by Each Reporting Person
            	1,450,000  

          10 Check Box if the Aggregate Amount in Row (9) Excludes Certain
                Shares*
             NOT APPLICABLE

          11 Percent of Class Represented by Amount in Row 9
             10.4%

          12 Type of Reporting Person*
             CO

                   *SEE INSTRUCTION BEFORE FILLING OUT


CUSIP NO. 401829106           			  13G      			 Page 3 of 4 Pages

Item 1(a).  Name of Issuer
Guilford Pharmaceuticals Inc.

Item 1(b).  Address of Issuer's Principal Executive Offices
6611 Tributary Street
Baltimore, MD  21224

Item 2(a).  Name of Person Filing
Scios Inc. (formerly Scios Nova Inc.)

Item 2(b).  Address of Principal Business Office
2450 Bayshore Parkway
Mountain View, CA 94043

Item 2(c).  Citizenship
Delaware

Item 2(d).  Title of Class of Securities
Common Stock

Item 2(e).  CUSIP No.
401829 10 6

Item 3.  If This Statement Is Filed Pursuant to Rules 13d-1(b) or 13d-2(b)
Not applicable

Item 4.  Ownership
 (a) Amount Beneficially Owned:
     1,450,000
 (b) Percent of Class:
     10.4%
 (c) Number of shares as to which such person has:
     (i) 	sole power to vote or to direct the vote: 1,450,000
     (ii)	shared power to vote or to direct the vote: None
     (iii)  sole power to dispose or to direct the disposition of: 1,450,000
     (iv)	shared power to dispose or to direct the disposition of: None

Item 5.  Ownership of Five Percent or Less of a Class
Not applicable

Item 6.  Ownership of More Than Five Percent on Behalf of Another Person
Not applicable

Item 7.  Identification and Classification of the Subsidiary Which Acquired 
         the Security Being Reported on by the Parent Holding Company
Not applicable



CUSIP NO. 401829106           			  13G      			 Page 4 of 4 Pages

Item 8.  Identification and Classification of Members of the Group
Not applicable

Item 9.  Notice of Dissolution of Group
Not applicable

Item 10.  Certification
Not applicable



                                	SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I 
certify that the information set forth in this statement is true, complete 
and correct.

Date: 	February 12, 1997


SCIOS INC.

/s/ John H. Newman
By:_____________________________
John H. Newman
Vice President of Legal Affairs,
General Counsel and Secretary