-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
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 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 GbXGjDRDQjAs0GSWcpzk7RXQKsUkOZIPntiR3AcMSE2P39qF+QKVbnvCR0CdN+Iw
 9CVtbaMJh0LOXe67fZJVbw==

<SEC-DOCUMENT>0000725058-04-000010.txt : 20040415
<SEC-HEADER>0000725058-04-000010.hdr.sgml : 20040415
<ACCEPTANCE-DATETIME>20040415161758
ACCESSION NUMBER:		0000725058-04-000010
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20040414
FILED AS OF DATE:		20040415

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			LYTLE THOMAS S
		CENTRAL INDEX KEY:			0001285609

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-14879
		FILM NUMBER:		04736090

	MAIL ADDRESS:	
		STREET 1:		C/O CYTOGEN CORP
		STREET 2:		650 COLLEGE ROAD EAST
		CITY:			PRINCETON
		STATE:			NJ
		ZIP:			08540

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			CYTOGEN CORP
		CENTRAL INDEX KEY:			0000725058
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				222322400
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		650 COLLEGE RD EAST STE 3100
		CITY:			PRINCETON
		STATE:			NJ
		ZIP:			08540
		BUSINESS PHONE:		6099878200

	MAIL ADDRESS:	
		STREET 1:		650 COLLEGE RD EAST STE 3100
		CITY:			PRINCETON
		STATE:			NJ
		ZIP:			08540
</SEC-HEADER>
<DOCUMENT>
<TYPE>3
<SEQUENCE>1
<FILENAME>form3_lytle031404ex.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0201</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2004-04-14</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0000725058</issuerCik>
        <issuerName>CYTOGEN CORP</issuerName>
        <issuerTradingSymbol>CYTO</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001285609</rptOwnerCik>
            <rptOwnerName>LYTLE THOMAS S</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O CYTOGEN CORPORATION</rptOwnerStreet1>
            <rptOwnerStreet2>650 COLLEGE ROAD EAST CN-5308</rptOwnerStreet2>
            <rptOwnerCity>PRINCETON</rptOwnerCity>
            <rptOwnerState>NJ</rptOwnerState>
            <rptOwnerZipCode>08540</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>Senior VP, Sales and Marketing</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <derivativeTable>
        <derivativeHolding>
            <securityTitle>
                <value>Options to Purchase Common Stock</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>11.045</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <value>2005-04-14</value>
                <footnoteId id="F1"/>
            </exerciseDate>
            <expirationDate>
                <value>2014-04-14</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock, $0.01 par value per share</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>30000</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">Such options were granted to Mr. Lytle upon his commencement of employment with the Company, and vest, subject to certain criteria, as follows:  (i) 10,000 on 04/14/05; (ii) 10,000 on 04/14/06; and (iii) 10,000 on 04/14/07.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Thomas Lytle</signatureName>
        <signatureDate>2004-04-14</signatureDate>
    </ownerSignature>
</ownershipDocument>

</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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