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Note 5 - Revenue (Details Textual) - USD ($)
3 Months Ended
Mar. 31, 2022
Mar. 31, 2021
Revenue from Contract with Customer, Including Assessed Tax $ 85,000 $ 506,000
Income Tax Expense (Benefit), Total $ 20,000 38,000
Foreign Tax Authority [Member] | National Tax Agency, Japan [Member]    
Royalty Withholding Tax 5.00%  
Income Tax Expense (Benefit), Total $ 4,000 25,000
Royalty [Member] | Daiichi Sankyo Collaberation and License Agreement [Member]    
Royalty Percentage 4.00%  
Revenue from Contract with Customer, Including Assessed Tax $ 0 0
Non Cash Royalty Revenue [Member]    
Revenue from Contract with Customer, Including Assessed Tax 85,000 493,000
Non Cash Royalty Revenue [Member] | Daiichi Sankyo Collaberation and License Agreement [Member]    
Revenue from Contract with Customer, Including Assessed Tax $ 85,000 $ 493,000