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Note 10 - Secured Promissory Note Payable to Oxford Finance (Details Textual) - USD ($)
12 Months Ended
Nov. 04, 2019
Dec. 22, 2016
Dec. 31, 2019
Dec. 31, 2018
Feb. 13, 2018
Debt Conversion, Converted Instrument, Amount     $ 35,577,000  
Amortization of Debt Issuance Costs $ 98,000        
Legal Fees $ 2,000        
Warrants in Connection with Loan Agreement [Member]          
Class of Warrant or Right, Number of Securities Called by Warrants or Rights   7,563     10,914
Class of Warrant or Right, Exercise Price of Warrants or Rights   $ 33.11     $ 22.99
Warrants Not Settleable in Cash, Fair Value Disclosure   $ 134,000     $ 70,000
Loan Agreement [Member] | Oxford Finance [Member]          
Long-term Debt, Gross   $ 5,000,000      
Debt Instrument, Term   4 years      
Debt Instrument, Periodic Payment Terms, Balloon Payment to be Paid   $ 325,000      
Debt Conversion, Converted Instrument, Amount   $ 250,000      
Debt Instrument, Interest Rate, Effective Percentage         10.50%
Interest Expense, Debt, Total     311,000 526,000  
Interest Paid, Including Capitalized Interest, Operating and Investing Activities, Total     $ 223,000 $ 356,000  
Loan Agreement [Member] | Oxford Finance [Member] | London Interbank Offered Rate (LIBOR) [Member]          
Debt Instrument, Basis Spread on Variable Rate   6.17%