Commitments and Contingencies - Additional Information (Detail) (USD $)	12 Months Ended				12 Months Ended			1 Months Ended		12 Months Ended			12 Months Ended
	Dec. 31, 2012 M Y D Employee sqft	Dec. 31, 2011	Dec. 31, 2010	Jan. 23, 2012 sqft	Dec. 31, 2012 Bio-Technology General (Israel) Ltd	Dec. 31, 2012 Sigma-Tau PharmaSource, Inc	Dec. 31, 2012 NOF Corporation	Jan. 31, 2013 NOF Corporation Reserve for Inventory Purchase and Other Contractual Commitments	Dec. 31, 2013 NOF Corporation Reserve for Inventory Purchase and Other Contractual Commitments	Dec. 31, 2012 Mountain View Pharmaceuticals And Duke University	Dec. 31, 2012 Mountain View Pharmaceuticals And Duke University Minimum	Dec. 31, 2012 Mountain View Pharmaceuticals And Duke University Maximum	Dec. 31, 2012 Stock Retention Awards	Dec. 31, 2012 During 2013	Dec. 31, 2012 During 2013 Retention Agreement	Dec. 31, 2012 During 2014 Retention Agreement
Commitments and Contingencies Disclosure [Line Items]
Severance costs	$ 700,000
Potential commitment of retention awards														1,100,000	800,000	800,000
Office space under lease, square feet	53,000			48,000
New lease term, months	123
Number of lease renewal options	2
Number of years lease agreement, renewal option	5
Aggregate minimum lease commitment	15,200,000
Letter of credit to secure obligations under lease	1,600,000
Tenant improvement allowance	2,000,000
Average annual rental expense	1,900,000
Rental agreement expiration date	March 2013
Rent expense charged to operations	2,600,000	2,000,000	1,900,000
Number of senior officers with employment agreements	8
Annual employee benefits compensation committed	3,100,000
Number of years employment agreement renewed, period	One year
Term of employment agreement, in years	3
Retention awards vesting percentage of award on specific dates	50.00%
Award vesting period, years	2 years
Stock compensation expense	6,932,000	7,900,000	7,784,000										800,000
Stock compensation expected to be recognized in 2013													900,000
Minimum percentage of purchase committed					80.00%
Initial advance notice period beginning, date	2015-12
Initial advance notice period ending, date	2018-12
Notice required to terminate supply agreement, in years	3
Termination of agreement after any written notice, maximum number of days required	30
Notice required for termination of service agreement, in days	45
Minimum percentage of supply to be made by supplier							75.00%
Percentage of minimum purchase obligation payable on termination							50.00%
Percentage of minimum purchase obligation payable on breach of purchase contract							50.00%
Minimum purchase obligation through 2017									4,800,000
Advance notice period for termination of contract prior expiration of term, month						24	24
Percentage of minimum purchase obligation for 2013 prepaid								50.00%
Maximum period for royalty payments, days										60
Percent of royalty rate payable on net sales											8.00%	12.00%
Aggregate payment to be made on attaining sales target										1,000,000
Percent of royalty payable on any revenue or other consideration receives from sub-licensees										20.00%
Funding received from OCS and BIRD	2,600,000
Royalty payment to BIRD	$ 600,000
Annual product worldwide manufacturing requirement percentage	100.00%