CONSOLIDATED STATEMENTS OF OPERATIONS (USD $) In Thousands, except Per Share data, unless otherwise specified	12 Months Ended
	Dec. 31, 2012	Dec. 31, 2011	Dec. 31, 2010
Revenues:
Product sales, net	$ 18,023	$ 9,565	$ 4,028
Cost and expenses:
Cost of goods sold	22,382	9,313	2,673
Research and development	26,238	24,790	32,358
Selling, general and administrative	88,501	90,898	24,981
Operating Expenses, Total	137,121	125,001	60,012
Operating loss	(119,098)	(115,436)	(55,984)
Investment income, net	164	150	116
Interest expense on debt	(23,892)	(16,357)
Gain on extinguishment of debt	21,800
Other income (expense), net	2,714	2,828	(17,250)
Loss before income taxes	(118,312)	(128,815)	(73,118)
Income tax benefit		(26,788)	(9)
Net loss	$ (118,312)	$ (102,027)	$ (73,109)
Loss per common share:
Basic and diluted	$ (1.67)	$ (1.46)	$ (1.08)
Weighted-average number of common shares:
Basic and diluted	70,819	70,117	67,435