Share-Based Compensation (Tables)

12 Months Ended

Dec. 31, 2012

Schedule of Stock-Based Compensation by Expense Category

The following table summarizes stock-based compensation related to the above plans by expense category for the years ended December 31, 2012, 2011 and 2010:

	Year Ended December 31,
	2012		2011		2010
	(In thousands)
Research and development	$	1,383	$	1,607	$	3,339
Selling, general and administrative		5,549		6,293		4,445
Total non-cash compensation expense related to share-based compensation included in operating expenses	$	6,932	$	7,900	$	7,784

Schedule of Unvested Stock Option Awards

The Company’s non-vested restricted stock, including RSU’s, at December 31, 2012 and 2011, and changes during the year ended December 31, 2012, are presented below:

	Number of Shares			Weighted-Average Grant Date Fair Value Per Share
	(Shares in thousands)
Unvested at December 31, 2011		811		$	8.75
Granted		1,854			1.83
Vested		(371	)		6.68
Forfeited		(464	)		6.45
Unvested at December 31, 2012		1,830		$	2.74

Stock Option

Schedule of Weighted-Average Key Assumptions Used in Determining Fair Value of Stock Option Awards

The weighted-average key assumptions used in determining the fair value of options granted for the years ended December 31, 2012, 2011 and 2010, are as follows:

	Year Ended December 31,
	2012			2011			2010
Weighted-average volatility		96	%		88	%		80	%
Weighted-average risk-free interest rate		0.9	%		2.1	%		2.3	%
Weighted-average expected term in years		5.5			4.4			6.5
Dividend yield		0.0	%		0.0	%		0.0	%
Weighted-average grant date fair value per share	$	1.31		$	5.05		$	8.52

Schedule of Stock Option Activity

The Company’s stock options at December 31, 2012 and 2011, and changes during the year ended December 31, 2012, are presented below:

	Number of Shares			Weighted- Average Exercise Price Per Share		Weighted- Average Remaining Contractual Term (In years)		Aggregate Intrinsic Value of In-the-Money Options
	(In thousands, except weighted-average data)
Outstanding at December 31, 2011		3,648		$	7.98		7.81	$	—
Granted		1,806			1.75		—		—
Exercised		—			—		—		—
Cancelled		(1,427	)		8.22		—		—
Outstanding at December 31, 2012		4,027		$	5.16		7.76	$	208
Exercisable at December 31, 2012		2,047		$	6.10		6.58	$	88

Stock Options That Contain Performance And Market-Based Conditions

Schedule of Weighted-Average Key Assumptions Used in Determining Fair Value of Stock Option Awards

The weighted-average key assumptions used in determining the fair value of performance options granted for the years ended December 31, 2012, 2011 and 2010, are as follows:

	Year Ended December 31,
	2012			2011			2010
Weighted-average volatility		97	%		88	%		80	%
Weighted-average risk-free interest rate		0.7	%		2.6	%		2.0	%
Weighted-average expected life in years		5.0			6.6			6.3
Dividend yield		0.0	%		0.0	%		0.0	%
Weighted-average grant date fair value per share	$	0.62		$	7.43		$	8.43

Schedule of Stock Option Activity

The Company’s performance options at December 31, 2012 and 2011, and changes during the year ended December 31, 2012, are presented below:

	Number of Shares			Weighted- Average Exercise Price Per Share		Weighted- Average Remaining Contractual Term (In years)		Aggregate Intrinsic Value of In-the-Money Options
	(In thousands, except weighted-average data)
Outstanding at December 31, 2011		440		$	9.75		9.07	$	—
Granted		830			2.07		—		—
Exercised		—			—		—		—
Cancelled		(317	)		7.75		—		—
Outstanding at December 31, 2012		953		$	3.73		9.30	$	74
Exercisable at December 31, 2012		40		$	13.81		6.91	$	—