SC 13G 1 0001.txt SCHEDULE 13G UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 Bio-Technology General Corp. ---------------------------- (Name of Issuer) Common Stock ---------------------------- (Title of Class of Securities) 090578105 ------------ (CUSIP Number) August 16, 2000 ----------------------------------------------------- (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which this Schedule is filed: [ ] Rule 13d-1(b) [X] Rule 13d-1(c) [ ] Rule 13d-1(d) *The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page. The information required in the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes). CUSIP No. 090578105 1. Names of Reporting Persons. I.R.S. Identification Nos. of above persons (entities only). OrbiMed Advisers Inc. 2. Check the Appropriate Box if a Member Of a Group (See Instructions) [ ] (a) [ ] (b) 3. SEC Use Only 4. Citizenship or Place of Organization British Virgin Islands Number of 5. Sole Voting Power 0 Shares Beneficially 6. Shared Voting Power 2,794,000 Owned by Each Reporting 7. Sole Dispositive Power 0 Person With 8. Shared Dispositive Power 2,794,000 9. Aggregate Amount Beneficially Owned by Each Reporting Person 2,794,000 10. Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) 11. Percent of Class Represented by Amount in Row (9) 5.12% 12. Type of Reporting Person (See Instructions) IA ------------------------ CUSIP No. 090578105 1. Names of Reporting Persons. I.R.S. Identification Nos. of above persons (entities only). OrbiMed Advisors LLC 2. Check the Appropriate Box if a Member of a Group (See Instructions) [ ] (a) [ ] (b) 3. SEC Use Only 4. Citizenship or Place of Organization Delaware Number of 5. Sole Voting Power 0 Shares Beneficially 6. Shared Voting Power 2,794,000 Owned by Each Reporting 7. Sole Dispositive Power 0 Person With 8. Shared Dispositive Power 2,794,000 9. Aggregate Amount Beneficially Owned by Each Reporting Person 2,794,000 10. Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) 11. Percent of Class Represented by Amount in Row (9) 5.12% 12. Type of Reporting Person (See Instructions) CO ------------------------ CUSIP No. 090578105 1. Names of Reporting Persons. I.R.S. Identification Nos. of above persons (entities only). Caduceus Capital Trust 2. Check the Appropriate Box if a Member of a Group (See Instructions) [ ] (a) [ ] (b) 3. SEC Use Only 4. Citizenship or Place of Organization Bermuda Number of 5. Sole Voting Power 0 Shares Beneficially 6. Shared Voting Power 2,794,000 Owned by Each Reporting 7. Sole Dispositive Power 0 Person With 8. Shared Dispositive Power 2,794,000 9. Aggregate Amount Beneficially Owned by Each Reporting Person 2,794,000 10. Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) 11. Percent of Class Represented by Amount in Row (9) 5.12% 12. Type of Reporting Person (See Instructions) OO ------------------------ CUSIP No. 090578105 1. Names of Reporting Persons. I.R.S. Identification Nos. of above persons (entities only). Caduceus Capital II, L.P. 2. Check the Appropriate Box if a Member of a Group (See Instructions) [ ] (a) [ ] (b) 3. SEC Use Only 4. Citizenship or Place of Organization Delaware Number of 5. Sole Voting Power 0 Shares Beneficially 6. Shared Voting Power 2,794,000 Owned by Each Reporting 7. Sole Dispositive Power 0 Person With 8. Shared Dispositive Power 2,794,000 9. Aggregate Amount Beneficially Owned by Each Reporting Person 2,794,000 10. Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) 11. Percent of Class Represented by Amount in Row (9) 5.12% 12. Type of Reporting Person (See Instructions) PN ------------------------ CUSIP No. 090578105 1. Names of Reporting Persons. I.R.S. Identification Nos. of above persons (entities only). PaineWebber Eucalyptus Fund, LLC 2. Check the Appropriate Box if a Member of a Group (See Instructions) [ ] (a) [ ] (b) 3. SEC Use Only 4. Citizenship or Place of Organization Delaware Number of 5. Sole Voting Power 0 Shares Beneficially 6. Shared Voting Power 2,794,000 Owned by Each Reporting 7. Sole Dispositive Power 0 Person With 8. Shared Dispositive Power 2,794,000 9. Aggregate Amount Beneficially Owned by Each Reporting Person 2,794,000 10. Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) 11. Percent of Class Represented by Amount in Row (9) 5.12% 12. Type of Reporting Person (See Instructions) IV ------------------------ CUSIP No. 090578105 1. Names of Reporting Persons. I.R.S. Identification Nos. of above persons (entities only). PaineWebber Eucalyptus Fund, Ltd. 2. Check the Appropriate Box if a Member of a Group (See Instructions) [ ] (a) [ ] (b) 3. SEC Use Only 4. Citizenship or Place of Organization Cayman Islands Number of 5. Sole Voting Power 0 Shares Beneficially 6. Shared Voting Power 2,794,000 Owned by Each Reporting 7. Sole Dispositive Power 0 Person With 8. Shared Dispositive Power 2,794,000 9. Aggregate Amount Beneficially Owned by Each Reporting Person 2,794,000 10. Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) 11. Percent of Class Represented by Amount in Row (9) 5.12% 12. Type of Reporting Person (See Instructions) IV ------------------------ CUSIP No. 090578105 1. Names of Reporting Persons. I.R.S. Identification Nos. of above persons (entities only). Finsbury Worldwide Pharmaceutical Trust PLC 2. Check the Appropriate Box if a Member of a Group (See Instructions) [ ] (a) [ ] (b) 3. SEC Use Only 4. Citizenship or Place of Organization United Kingdom Number of 5. Sole Voting Power 0 Shares Beneficially 6. Shared Voting Power 2,794,000 Owned by Each Reporting 7. Sole Dispositive Power 0 Person With 8. Shared Dispositive Power 2,794,000 9. Aggregate Amount Beneficially Owned by Each Reporting Person 2,794,000 10. Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) 11. Percent of Class Represented by Amount in Row (9) 5.12% 12. Type of Reporting Person (See Instructions) CO ------------------------ CUSIP No. 090578105 1. Names of Reporting Persons. I.R.S. Identification Nos. of above persons (entities only). PHARMA/wHEALTH 2. Check the Appropriate Box if a Member of a Group (See Instructions) [ ] (a) [ ] (b) 3. SEC Use Only 4. Citizenship or Place of Organization Luxembourg Number of 5. Sole Voting Power 0 Shares Beneficially 6. Shared Voting Power 2,794,000 Owned by Each Reporting 7. Sole Dispositive Power 0 Person With 8. Shared Dispositive Power 2,794,000 ` 9. Aggregate Amount Beneficially Owned by Each Reporting Person 2,794,000 10. Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) 11. Percent of Class Represented by Amount in Row (9) 5.12% 12. Type of Reporting Person (See Instructions) OO ------------------------ CUSIP No. 090578105 1. Names of Reporting Persons. I.R.S. Identification Nos. of above persons (entities only). Eaton Vance Worldwide Health Services Fund 2. Check the Appropriate Box if a Member of a Group (See Instructions) [ ] (a) [ ] (b) 3. SEC Use Only 4. Citizenship or Place of Organization Massachusetts Number of 5. Sole Voting Power 0 Shares Beneficially 6. Shared Voting Power 2,794,000 Owned by Each Reporting 7. Sole Dispositive Power 0 Person With 8. Shared Dispositive Power 2,794,000 9. Aggregate Amount Beneficially Owned by Each Reporting Person 2,794,000 10. Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) 11. Percent of Class Represented by Amount in Row (9) 5.12% 12. Type of Reporting Person (See Instructions) IV -------------------------------------------------------------------------------- Item 1. (a) Issuer: Bio-Technology General Corp. (b) Address: 70 Wood Avenue South Iselin, NJ 08830 Item 2. (a) Name of Person Filing: OrbiMed Advisers Inc. OrbiMed Advisors LLC Caduceus Capital Trust Caduceus Captital II, L.P. PaineWebber Eucalyptus Fund, LLC PaineWebber Eucalyptus Fund, Ltd. Finsbury Worldwide Pharmaceutical Trust PLC PHARMA/wHEALTH Eaton Vance Worldwide Health Sciences Fund (b) Address of Principal Business Offices: c/o OrbiMed Advisors LLC 767 Third Avenue, 6th Floor New York, New York 10010 (c) Citizenship: Please refer to Item 4 on each cover sheet for each filing person (d) Title of Class of Securities Common stock (e) CUSIP Number: 090578105 Item 3. Not Applicable Item 4. Ownership Please see Items 5 - 9 and 11 for each cover sheet for each filing separately Item 5. Ownership of Five Percent or Less of a Class Not Applicable Item 6. Ownership of More than Five Percent on Behalf of Another Person. Not Applicable Item 7. Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company Not Applicable Item 8. Identification and Classification of Members of the Group Not Applicable Item 9. Notice of Dissolution of Group Not Applicable Item 10. Certification By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect. SIGNATURE After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct. Date: September 19, 2000 OrbiMed Advisers Inc. By: /s/ Samuel D. Isaly ---------------------------- Name: Samuel D. Isaly Title: President OrbiMed Advisors LLC By: /s/ Samuel D. Isaly ---------------------------- Name: Samuel D. Isaly Title: Managing Member Caduceus Capital Trust By: /s/ Samuel D. Isaly ---------------------------- Name: Samuel D. Isaly Title: Portfolio Manager Caduceus Captital II, L.P. By: /s/ Samuel D. Isaly ---------------------------- Name: Samuel D. Isaly Title: Portfolio Manager PaineWebber Eucalyptus Fund, LLC By: /s/ Samuel D. Isaly ---------------------------- Name: Samuel D. Isaly Title: Portfolio Manager PaineWebber Eucalyptus Fund, Ltd. By: /s/ Samuel D. Isaly ---------------------------- Name: Samuel D. Isaly Title: Portfolio Manager Finsbury Worldwide Pharmaceutical Trust PLC By: /s/ Samuel D. Isaly ---------------------------- Name: Samuel D. Isaly Title: Portfolio Manager PHARMA/wHEALTH By: /s/ Samuel D. Isaly ---------------------------- Name: Samuel D. Isaly Title: Portfolio Manager Eaton Vance Worldwide Health Sciences Fund By: /s/ Samuel D. Isaly ---------------------------- Name: Samuel D. Isaly Title: Portfolio Manager