<ARTICLE> 5
<LEGEND>
THIS SCHEDULE CONTAINS SUMMARY FINANCIAL INFORMATION EXTRACTED FROM THE
CONSOLIDATED FINANCIAL STATEMENTS OF MOLECULAR BIOSYSTEMS INC. DATED MARCH 31,
2000 AND IS QUALIFIED IN ITS ENTIRETY BY REFERENCE TO SUCH FINANCIAL STATEMENTS.

<MULTIPLIER> 1,000
<CURRENCY> U.S. DOLLARS

                             
<PERIOD-TYPE>                   YEAR
<FISCAL-YEAR-END>                          MAR-31-2000
<PERIOD-START>                             APR-01-1999
<PERIOD-END>                               MAR-31-2000
<EXCHANGE-RATE>                                      1
<CASH>                                           1,756
<SECURITIES>                                    10,287
<RECEIVABLES>                                    1,820
<ALLOWANCES>                                         0
<INVENTORY>                                        203
<CURRENT-ASSETS>                                14,270
<PP&E>                                          14,156
<DEPRECIATION>                                   7,572
<TOTAL-ASSETS>                                  22,644
<CURRENT-LIABILITIES>                           10,446
<BONDS>                                          3,529
<PREFERRED-MANDATORY>                                0
<PREFERRED>                                          0
<COMMON>                                           186
<OTHER-SE>                                       8,483
<TOTAL-LIABILITY-AND-EQUITY>                    22,644
<SALES>                                          1,525
<TOTAL-REVENUES>                                 8,525
<CGS>                                            (107)
<TOTAL-COSTS>                                   15,973
<OTHER-EXPENSES>                                     0
<LOSS-PROVISION>                                     0
<INTEREST-EXPENSE>                                 447
<INCOME-PRETAX>                                (7,168)
<INCOME-TAX>                                     (400)
<INCOME-CONTINUING>                            (7,568)
<DISCONTINUED>                                       0
<EXTRAORDINARY>                                      0
<CHANGES>                                            0
<NET-INCOME>                                   (7,568)
<EPS-BASIC>                                      (.40)
<EPS-DILUTED>                                    (.40)