Exhibit 23.1

Consent of Independent Registered Public Accounting Firm

We consent to the incorporation by reference in the Registration Statements (Form S-3 Nos. 333-01071, 333-04323, 333-15483, 333-39759, 333-66269, 333-87038, 333-104954, 333-110158 and 333-124779, and Form S-8 Nos. 333-06771, 333-06765, 333-19465, 333-59164, 333-88544, 333-116662, 333-147258 and 333-161264) of Cypress Bioscience, Inc. and in the related Prospectus of our reports dated March 30, 2010 with respect to the consolidated financial statements of Cypress Bioscience, Inc., and the effectiveness of internal control over financial reporting of Cypress Bioscience, Inc., included in this Annual Report (Form 10-K) for the year ended December 31, 2009.

/s/ Ernst & Young LLP

San Diego, California
March 30, 2010