-----BEGIN PRIVACY-ENHANCED MESSAGE----- Proc-Type: 2001,MIC-CLEAR Originator-Name: webmaster@www.sec.gov Originator-Key-Asymmetric: MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB MIC-Info: RSA-MD5,RSA, HwKStIaoUwHMtA9OBCFmb0LS/Z/HSyelvOpGHIHX3Y0s+NwSXygL/LmOHdzWl0Kn nQbz8V8aSMqim4pEdyJcaQ== 0001104659-07-018535.txt : 20070313 0001104659-07-018535.hdr.sgml : 20070313 20070313130324 ACCESSION NUMBER: 0001104659-07-018535 CONFORMED SUBMISSION TYPE: 8-K PUBLIC DOCUMENT COUNT: 5 CONFORMED PERIOD OF REPORT: 20070308 ITEM INFORMATION: Results of Operations and Financial Condition ITEM INFORMATION: Other Events ITEM INFORMATION: Financial Statements and Exhibits FILED AS OF DATE: 20070313 DATE AS OF CHANGE: 20070313 FILER: COMPANY DATA: COMPANY CONFORMED NAME: LIPID SCIENCES INC/ CENTRAL INDEX KEY: 0000071478 STANDARD INDUSTRIAL CLASSIFICATION: BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836] IRS NUMBER: 430433090 STATE OF INCORPORATION: AZ FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: 8-K SEC ACT: 1934 Act SEC FILE NUMBER: 000-00497 FILM NUMBER: 07689914 BUSINESS ADDRESS: STREET 1: 7068 KOLL CENTER PARKWAY STREET 2: SUITE 401 CITY: PLEASANTON STATE: CA ZIP: 94566 BUSINESS PHONE: 925-249-4000 MAIL ADDRESS: STREET 1: 7068 KOLL CENTER PARKWAY STREET 2: SUITE 401 CITY: PLEASANTON STATE: CA ZIP: 94566 FORMER COMPANY: FORMER CONFORMED NAME: NZ CORP DATE OF NAME CHANGE: 20000810 FORMER COMPANY: FORMER CONFORMED NAME: NEW MEXICO & ARIZONA LAND CO DATE OF NAME CHANGE: 19920703 8-K 1 a07-7610_18k.htm 8-K

 

 

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549


 

FORM 8-K

CURRENT REPORT

Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

Date of Report (Date of earliest event reported)March 8, 2007

LIPID SCIENCES, INC.

(Exact name of registrant as specified in its charter)


 

Delaware

 

0-497

 

43-0433090

(State or other jurisdiction of incorporation)

 

(Commission File Number)

 

(I.R.S Employer Identification No.)

 

7068 Koll Center Parkway, Suite 401, Pleasanton, California

 

94566

(Address of principal executive offices)

 

(Zip Code)

 

Registrant’s telephone number, including area code:  (925) 249-4000

(Former name or former address, if changed since last report.)  N/A


 

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instruction A.2. below):

o  Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

o  Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

o  Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

o  Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

 




Item 2.02 Results of Operations and Financial Condition.

On March 13, 2007, Lipid Sciences, Inc. issued a press release entitled “Lipid Sciences, Inc. Reports Financial Results for the Fourth Quarter and Year End 2006.”  A copy of the press release is furnished as Exhibit 99.1 to this report.

The information in this Item 2.02, including 99.1 exhibit hereto, is being furnished and shall not be deemed “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), or otherwise subject to the liabilities of that section.  In addition, the information in this Item 2.02 shall not be incorporated by reference into any document filed under the Securities Act of 1933, as amended, or the Exchange Act, regardless of any general incorporating language in such filing, except as shall be expressly set forth by specific reference in such filing.

Item 8.01 Other Events.

On March 8, 2007, Lipid Sciences, Inc. announced in a press release data presented at the Cardiovascular Revascularization Therapies: CRT 2007 Symposium highlighting the scientific basis for the Company’s proprietary HDL Selective Delipidation process.  In addition, Dr. Ron Waksman, Associate Director, Division of Cardiology, Washington Hospital Center, and Principal Investigator of the Company’s “first in man” clinical trial, reported that 82 patients had consented to be part of, and 14 patients had been enrolled in, the Company’s clinical trial “A Randomized, Single-Blind, Placebo-Controlled Study to Evaluate the Safety of the Lipid Sciences’ HDL Selective Delipidation System, PDS-2.” Dr. Waksman further commented that all plasma infusions had been well tolerated and the Data Safety and Monitoring Committee has authorized the continuation of the clinical trial after review of the patient safety data to date.  The Company announced that the current clinical trial is anticipated to conclude during the second half of 2007, followed by the initiation of a follow-on effectiveness trial in early 2008.  A copy of the press release is filed as Exhibit 99.2 to this report and incorporated herein by reference.

Item 9.01 Financial Statements and Exhibits.

(d) Exhibits.

Exhibit 99.1

 

Press release entitled “Lipid Sciences, Inc. Reports Financial Results for the Fourth Quarter and Year End 2006.”

Exhibit 99.2

 

Press release entitled “New Data Validating Lipid Sciences’ HDL Selective Delipidation Process Presented at CRT 2007.”

 

2




SIGNATURE

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

 

 

 

Lipid Sciences, Inc.

 

 

 

 

 

 

 

 

 

 

Date: March 13, 2007

 

By:

 

/s/ Sandra Gardiner

 

 

 

 

Sandra Gardiner

 

 

 

 

Chief Financial Officer

 

3




EXHIBIT INDEX

Exhibit

 

 

 

Description

Exhibit 99.1

 

Press release entitled “Lipid Sciences, Inc. Reports Financial Results for the Fourth Quarter and Year End 2006.”

Exhibit 99.2

 

Press release entitled “New Data Validating Lipid Sciences’ HDL Selective Delipidation Process Presented at CRT 2007.”

 

4



EX-99.1 2 a07-7610_1ex99d1.htm EX-99.1

Exhibit 99.1

FOR FURTHER INFORMATION CONTACT:

Deborah S. Lorenz

Vice President, Investor Relations and

Corporate Communications

Lipid Sciences, Inc.

925-249-4031

dlorenz@lipidsciences.com

 

FOR IMMEDIATE RELEASE:

MARCH 13, 2007

 

LIPID SCIENCES, INC. REPORTS FINANCIAL RESULTS

FOR THE FOURTH QUARTER AND YEAR-END 2006

 

New Data Validating Lipid Sciences’ HDL Selective Delipidation Process Presented at CRT 2007

PLEASANTON, Calif., March 13, 2007 — Lipid Sciences, Inc. (Nasdaq:LIPD) today reported financial results for the fourth quarter and year-ended December 31, 2006.  For the fourth quarter of 2006, the Company reported a net loss of $2.7 million, or $0.08 per share on a basic and diluted basis.  This compares with a net loss of $2.6 million, or $0.10 per share, on a basic and diluted basis, for the same period in 2005.

Operating expenses for the fourth quarter reflected a 3% decrease in research and development expenditures from the same period of the previous year.  This decrease is related to the clinical trial for HDL Selective Delipidation being conducted at the Washington Hospital Center, as the start-up costs of the trial were incurred in the fourth quarter of 2005 and were greater than the ongoing implementation costs.  The 17% increase in SG&A is due to the increase in non-cash stock compensation expense as a result of the Company’s adoption of FAS 123(R).  FAS 123(R) requires the recognition of the fair value of employee stock options in the income statement, rather than as a pro forma disclosure, as allowed in prior periods.

For the year ended December 31, 2006, the Company reported a net loss of $11.2 million, or $0.38 per share, on a basic and diluted basis.  This compares with a net loss of $10.2 million or $0.40 per share on a basic and diluted basis, for the prior fiscal year.

For the year ended December 31, 2006, operating expenses increased by 11% to $11.8 million up from $10.7 million in the previous year.  Research and development expenses, which accounted for 64% of the Company’s operating expenses for the year ended December 31, 2006, increased 5% to $7.6 million from $7.1 million for the same period in 2005.  The increase was primarily attributed to costs surrounding the launch and ongoing implementation of the clinical trial, legal fees related to protection and expansion of the Company’s patent portfolio, and non-cash stock compensation expense related to the implementation of FAS 123(R) in the first quarter of 2006.

At December 31, 2006, the Company had approximately $16.7 million in cash, cash equivalents, and short-term investments.  This total reflects gross proceeds of approximately $6.2 million from the Company’s private placement that closed in December 2006.  The Company anticipates that sufficient capital is available to fund its operations, including current development projects, to the second half of 2008.

Dr. S. Lewis Meyer, President and Chief Executive Officer, noted, “Compelling new data presented at the recent Cardiovascular Revascularization Therapies:  CRT 2007 Symposium highlighted that, in a clinical trial setting, Lipid Sciences’ HDL Selective Delipidation process consistently and reliably creates a high concentration of a modified form of HDL, or ‘good cholesterol’.  This modified form of HDL was shown to be significantly more effective in removing cholesterol from cells because it contained approximately 28 times more pre-beta, or scavenger, HDL than undelipidated plasma.  Based on this strong scientific data, we are highly confident that our HDL Selective Delipidation therapy could have a profound impact on the treatment regimen of cardiovascular disease in the critical Acute Coronary Syndrome (ACS) patient population.”




Dr. Meyer continued, “In our ‘first in man’ trial, currently underway at the Washington Hospital Center in Washington, D.C.,  82 patients consented to be part of this trial to date, and 14 met the stringent inclusion criteria and are enrolled.  The plasma infusions are well tolerated by all.  A total of 30 stable ACS patients will be recruited into this trial.  At the current rate of enrollment, we anticipate concluding this trial during the second half of 2007 and plan to initiate a follow-on effectiveness trial in early 2008.”

Selectively Delipidated HDL Significantly More Effective in Removing Cholesterol from Cells Than Naturally-Occurring HDL—New Data Presented at CRT 2007

New data was presented at the Cardiovascular Revascularization Therapies: CRT 2007 Symposium highlighting the scientific basis of Lipid Sciences’ proprietary HDL Selective Delipidation process that is currently being evaluated in a clinical trial setting at the Washington Hospital Center (WHC).

At the conclusion of his presentation, “The Torcetrapib Story: Do HDL Cholesterol-Raising Therapies Still Have a Future?” Dr. H. Bryan Brewer, Jr., Chief Scientific Director of Lipid Sciences commented, “With the recent setback in the clinical trial of the CETP inhibitor, Torcetrapib, the field of HDL Therapy is now wide open for novel solutions to address the significant unmet clinical need in the treatment of cardiovascular disease.  Statistics show that 80% of Acute Coronary Syndrome patients have one or more ruptured plaques in addition to the culprit lesion that brought them to the hospital initially.  Furthermore, more than 1 in 5 of these patients will experience a second coronary event within 24 months.  Lipid Sciences is well positioned to respond to this potential opportunity with the development of two new therapeutic tools for the cardiology community—a medical device and an HDL Mimetic Peptide—both intended to enhance the reverse cholesterol transport process with the goal of plaque regression in the cardiovascular system.”

For additional information about the data presented at CRT 2007, please read our press release dated March 8, 2007 which can be found on our website at www.lipidsciences.com.

Lipid Sciences, Inc. is a development-stage biotechnology company engaged in the research and development of products and processes intended to treat major medical indications, in which lipids, or fat components, play a key role.  The Company’s HDL Therapy platform (HDL Selective Delipidation and HDL Mimetic Peptides)  aims to develop treatments to reverse atherosclerosis, a systemic disease of the blood vessels caused by the build-up of cholesterol-filled plaques in the vascular system and, most critically, in the coronary arteries. Regression of such plaques may have a major impact on reducing the risk of acute coronary events.  The Company’s Viral Immunotherapy platform focuses on the removal of the lipid coatings from lipid-enveloped viruses and other lipid-containing infectious agents by applying Lipid Sciences’ proprietary delipidation technologies.  The Company believes that removing the virus’ protective lipid coating enhances the processing and presentation of viral proteins to stimulate the body’s immune system to effectively fight the disease.  Conditions that could potentially be impacted by these technologies include HIV, Hepatitis B and Hepatitis C, West Nile, SARS, influenza, and a broad range of animal health applications.

Forward-Looking Statements:  This release contains forward-looking statements concerning plans, objectives, goals, strategies, study results, anticipations, expectations, future events or performance as well as all other statements that are not statements of historical fact.  The forward-looking statements contained in this release reflect our current beliefs and expectations on the date of this release.  Actual results, performance or outcomes may differ materially from what is expressed in the forward-looking statements.  Readers are referred to the documents filed by us with the SEC, specifically the most recent reports on Form 10-K and Form 10-Q which identify important risk factors that could cause actual results to differ from those contained in the forward-looking statements.  In addition to those risk factors, other factors that could cause actual results to differ materially include the following:  Our inability to obtain adequate funds; the significant losses we have incurred to date, and our expectation that we will incur substantial losses in the future; the failure of our technologies to prove safe or effective; our inability to obtain regulatory approval for our technologies, which is only in the clinical development stage; delay or failure to complete clinical studies; our dependence on our license agreement with Aruba International B.V.; our reliance on collaborations with strategic partners and consultants; competition in our industry, including the development of new products by others that may provide alternative or better therapies; failure to secure and enforce our intellectual property rights; risks associated with use of biological and hazardous materials; acceptance of our potential products by healthcare providers and patients; our exposure to product liability claims; and our dependence on key personnel.

This release should be read in conjunction with the consolidated financial statements and notes thereto included in our most recent reports on Form 10-K and Form 10-Q.  Copies are available through the SEC’s Electronic Data Gathering Analysis and Retrieval system (EDGAR) at www.sec.gov.  Lipid Sciences assumes no obligation to update the forward-looking statements included in this document.

Press releases for Lipid Sciences, Inc. are available on our website: www.lipidsciences.com.  If you would like to receive our press releases via email, please contact: info@lipidsciences.com.




Lipid Sciences, Inc.

(A Development Stage Company)

Condensed Consolidated Statements of Operations

 

 

 

Three Months Ended

 

Twelve Months Ended

 

Period from
Inception
(May 21,
1999) to

 

 

 

December 31,

 

December 31,

 

December 31,

 

(In thousands, except per share amounts)

 

2006

 

2005

 

2006

 

2005

 

2006

 

Grant Revenue

 

$

21

 

$

8

 

$

59

 

$

9

 

$

100

 

Operating expenses:

 

 

 

 

 

 

 

 

 

 

 

Research and development (1)

 

1,828

 

1,887

 

7,559

 

7,170

 

59,807

 

Selling, general and administrative (2)

 

1,041

 

891

 

4,254

 

3,508

 

27,318

 

Total operating expenses

 

2,869

 

2,778

 

11,813

 

10,678

 

87,125

 

Operating loss

 

(2,848

)

(2,770

)

(11,754

)

(10,669

)

(87,025

)

Interest and other income

 

164

 

165

 

577

 

455

 

4,160

 

Loss from continuing operations

 

(2,684

)

(2,605

)

(11,177

)

(10,214

)

(82,865

)

Income tax benefit

 

 

 

 

 

8,004

 

Net loss from continuing operations

 

(2,684

)

(2,605

)

(11,177

)

(10,214

)

(74,861

)

Discontinued operations:

 

 

 

 

 

 

 

 

 

 

 

Income from discontinued operations

 

 

 

 

 

582

 

Income tax expense

 

 

 

 

 

(179

)

Income from discontinued operations - net

 

 

 

 

 

403

 

Net loss

 

$

(2,684

)

$

(2,605

)

$

(11,177

)

$

(10,214

)

$

(74,458

)

 

 

 

 

 

 

 

 

 

 

 

 

Loss per share — basic and diluted:

 

 

 

 

 

 

 

 

 

 

 

Net loss per share continuing operations

 

$

(0.08

)

$

(0.10

)

$

(0.38

)

$

(0.40

)

 

 

Income per share discontinued operations

 

$

0.00

 

$

0.00

 

$

0.00

 

$

0.00

 

 

 

Net loss per share

 

$

(0.08

)

$

(0.10

)

$

(0.38

)

$

(0.40

)

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Weighted average number of common shares outstanding — basic and diluted

 

33,020

 

27,359

 

29,501

 

25,529

 

 

 

Non-cash stock option compensation expense/(income) included in operating expenses:

 

 

 

 

 

 

 

 

 

 

 

(1)  Research and development

 

22

 

86

 

300

 

186

 

 

 

(2)  Selling, general and administrative

 

111

 

 

562

 

 

 

 

 




Lipid Sciences, Inc.

(A Development Stage Company)

Consolidated Balance Sheets
December 31

(In thousands, except share amounts)

 

2006

 

2005

 

ASSETS

 

 

 

 

 

Current assets:

 

 

 

 

 

Cash and cash equivalents

 

$

16,691

 

$

1,752

 

Short-term investments

 

 

12,836

 

Prepaid expenses

 

273

 

355

 

Other current assets

 

79

 

18

 

Total current assets

 

17,043

 

14,961

 

Property and equipment

 

374

 

419

 

Long-term lease deposits

 

19

 

19

 

Total assets

 

$

17,436

 

$

15,399

 

LIABILITIES AND STOCKHOLDERS’ EQUITY

 

 

 

 

 

Current liabilities:

 

 

 

 

 

Accounts payable and accrued liabilities

 

$

1,511

 

$

1,292

 

Accrued related party royalties

 

250

 

250

 

Accrued compensation

 

680

 

390

 

Total current liabilities

 

2,441

 

1,932

 

Deferred rent

 

16

 

9

 

Total liabilities

 

2,457

 

1,941

 

 

 

 

 

 

 

Stockholders’ equity:

 

 

 

 

 

Preferred stock, $0.001 par value; 10,000,000 shares authorized and issuable; no shares outstanding

 

 

 

Common stock, $0.001 par value; 75,000,000 shares authorized; 37,120,139 and 27,359,267 shares issued and outstanding at December 31, 2006 and 2005, respectively

 

37

 

27

 

Additional paid-in capital

 

89,400

 

76,712

 

Deficit accumulated in the development stage

 

(74,458

)

(63,281

)

Total stockholders’ equity

 

14,979

 

13,458

 

Total liabilities and stockholders’ equity

 

$

17,436

 

$

15,399

 

 



EX-99.2 3 a07-7610_1ex99d2.htm EX-99.2

Exhibit 99.2

FOR FURTHER INFORMATION CONTACT:

Deborah S. Lorenz

Vice President, Investor Relations and

Corporate Communications

Lipid Sciences, Inc.

925-249-4031

dlorenz@lipidsciences.com

FOR IMMEDIATE RELEASE:

March 8, 2007

NEW DATA VALIDATING LIPID SCIENCES’ HDL SELECTIVE DELIPIDATION PROCESS

PRESENTED AT CRT 2007

Delipidated HDL Significantly More Effective in Removing Cholesterol From Cells Than

Naturally-Occurring HDL

Proprietary Process Increases “Scavenger” HDL by 28X

Doctors Brewer and Waksman Present at

Cardiovascular Revascularization Therapies (CRT) 2007 Symposium

PLEASANTON, Calif., March 8, 2007 — Lipid Sciences, Inc. (Nasdaq:LIPD) announced today that new data presented at Cardiovascular Revascularization Therapies: CRT 2007 Symposium highlighted the scientific basis of Lipid Sciences’ proprietary HDL Selective Delipidation process that is currently being evaluated in a clinical trial setting at the Washington Hospital Center (WHC).  The data demonstrated that Lipid Sciences’ proprietary “Selective Delipdation” process applied to samples of human plasma can consistently create a high concentration of a modified form of HDL, or “good cholesterol”, that is known to be more effective in reverse cholesterol transport—the body’s natural process for removing lipids from arterial plaque.  The HDL Selective Delipidation process, as applied in this study, successfully transformed the more common alpha HDL into a form known as pre-beta HDL.  Pre-beta HDL has been shown to selectively remove lipids from lipid-filled cells commonly found in arterial plaque associated with atherosclerosis.  The delipidated plasma was shown to contain approximately 28 times more pre-beta HDL than the undelipidated (control) plasma.  The plasma processing was performed at the Washington Hospital Center, Washington, D.C.

The Selective Delipidation process reproducibly removed lipids from only the targeted HDL particles without significantly affecting or altering LDL or any other plasma lipoproteins.  This new and novel process transforms the less active alpha HDL into the scavenger, or pre-beta, HDL with no significant impact observed on other lipoproteins’ composition or metabolism.  Consistent with previous data, 78% of the HDL cholesterol was removed from the plasma samples, and 95% of the critical apolipoprotein A-I was preserved.  The delipidated HDL created was shown to be significantly more effective in removing cholesterol from cells than the unprocessed plasma, even exceeding the efflux capability of apolipoprotein A-I.




John J.P. Kastelein, M.D., Ph.D., Professor of Medicine at the University of Amsterdam and a member of the Lipid Sciences’ Scientific Advisory Board commented, “The results presented at the CRT 2007 Symposium clearly validate the concept of HDL Selective Delipidation.  The ability to remove cholesterol from the HDL particle while preserving the critical apolipoprotein A-I is clearly consistent with the finding that pre-beta HDL is increased by approximately 28 times in the processed plasma.  The in vitro demonstration of the markedly enhanced cholesterol efflux by selectively delipidated plasma provides further evidence of the utility of delipidated HDL in enhancing reverse cholesterol transport.  I am very encouraged that these data validating HDL Selective Delipidation show great promise as a powerful treatment for cardiovascular disease.”

Lipid Sciences is currently conducting a clinical trial at the WHC “A Randomized, Single-Blind, Placebo-Controlled Study to Evaluate the Safety of the Lipid Sciences’ HDL Selective Depilidation System, PDS-2, in Subjects with Acute Coronary Syndrome (ACS).”  The trial will consist of a total of 30 stable ACS patients, 15 of which will receive delipidation treatments in a series of 7 weekly plasma infusions.  The primary endpoint is the safety and feasibility of conducting the procedure; the exploratory endpoint is the intravascular ultrasound (IVUS) evaluation of the target coronary artery plaques both before and after treatment.

Dr. Ron Waksman, Associate Director, Division of Cardiology, Washington Hospital Center, and Principal Investigator of Lipid Sciences’ “first in man” clinical trial, discussed the trial’s progress in a presentation entitled, “HDL Therapy and Delipidation for Acute Coronary Syndrome.”  Dr. Waksman reported, “To date, 82 patients have consented to be part of this trial and 14 patients have met the stringent inclusion criteria and have been enrolled.  All plasma infusions have been well tolerated and the Data Safety and Monitoring Committee has authorized the continuation of the clinical trial after review of the patient safety data to date.”

Dr. S. Lewis Meyer, President and Chief Executive Officer of Lipid Sciences added, “At the current rate of enrollment in our clinical trial, we anticipate concluding this trial during the second half of 2007 and plan to initiate a follow-on effectiveness trial in early 2008.”  He continued, “Statistics show that 80% of Acute Coronary Syndrome patients have one or more ruptured plaques in addition to the culprit lesion that brought them to the hospital initially.  Furthermore, more than 1 in 5 of these patients will experience a second coronary event within 24 months.  Lipid Sciences’ HDL Selective Delipidation therapy could have a profound impact on the treatment regimen of cardiovascular disease in this critical patient population.”

Dr. H. Bryan Brewer, Jr., Chief Scientific Director of Lipid Sciences, commented at the conclusion of his presentation, “With the recent setback in the clinical trial of the CETP inhibitor, Torcetrapib, the field of HDL Therapy is now wide open for novel solutions to address the significant unmet clinical need in the treatment of cardiovascular disease.  Lipid Sciences is well positioned to respond to this potential opportunity with the development of two new therapeutic tools for the cardiology community — a medical device and an HDL Mimetic Peptide — both intended to enhance the reverse cholesterol transport process with the goal of plaque regression in the coronary arteries.”

Lipid Sciences’ HDL Selective Delipidation technology is a potentially radical approach to treating heart disease.  It is a systemic treatment designed to change the composition of the patient’s own HDL and to prevent the rupture of vulnerable plaque to stop the patient’s next heart attack or stroke.  Lipid Sciences has also begun work on the next generation of HDL therapy, an HDL Mimetic Peptide program.  The target market for this therapy is also the ACS patient.  This synthetic “HDL in a bottle” is expected to enhance the body’s naturally-occurring reverse cholesterol transport process.  If successful, it will mimic the biological activity of HDL to regress plaque and reduce inflammation.  Lipid Sciences’ HDL Mimetic Peptide is designed for cost-effective delivery as an infusion therapy.

Data supporting this CRT 2007 presentation is posted in the Investor Relations section of our website at www.lipidsciences.com.  In addition, an animated version of Lipid Sciences’ HDL Selective Delipidation process can be viewed in the Technology section of the website.




About CRT 2007

CRT 2007 is an international multi-modular symposium that covers a variety of evidence-based medical disciplines in the field of cardiovascular medicine and intervention.  A renowned faculty of international experts who are leaders in their field discuss mechanistic issues, clinical controversies and current experiences both in animal models and in clinical patient treatment settings.

Lipid Sciences, Inc. is a development-stage biotechnology company engaged in the research and development of products and processes intended to treat major medical indications, in which lipids, or fat components, play a key role.  The Company’s HDL Therapy platform (HDL Selective Delipidation and HDL Mimetic Peptides)  aims to develop treatments to reverse atherosclerosis, a systemic disease of the blood vessels caused by the build-up of cholesterol-filled plaques in the vascular system and, most critically, in the coronary arteries. Regression of such plaques may have a major impact on reducing the risk of acute coronary events.  The Company’s Viral Immunotherapy platform focuses on the removal of the lipid coatings from lipid-enveloped viruses and other lipid-containing infectious agents by applying Lipid Sciences’ proprietary delipidation technologies.  The Company believes that removing the virus’ protective lipid coating enhances the processing and presentation of viral proteins to stimulate the body’s immune system to effectively fight the disease.  Conditions that could potentially be impacted by these technologies include HIV, Hepatitis B and Hepatitis C, West Nile, SARS, influenza, and a broad range of animal health applications.

Forward-Looking Statements:  This release contains forward-looking statements concerning plans, objectives, goals, strategies, study results, anticipations, expectations, future events or performance as well as all other statements that are not statements of historical fact.  The forward-looking statements contained in this release reflect our current beliefs and expectations on the date of this release.  Actual results, performance or outcomes may differ materially from what is expressed in the forward-looking statements.  Readers are referred to the documents filed by us with the SEC, specifically the most recent reports on Form 10-K and Form 10-Q which identify important risk factors that could cause actual results to differ from those contained in the forward-looking statements.  In addition to those risk factors, other factors that could cause actual results to differ materially include the following:  Our inability to obtain adequate funds; the significant losses we have incurred to date, and our expectation that we will incur substantial losses in the future; the failure of our technology to prove safe or effective; our inability to obtain regulatory approval for our technology, which is only in the clinical development stage; delay or failure to complete clinical studies; our dependence on our license agreement with Aruba International B.V.; our reliance on collaborations with strategic partners and consultants; competition in our industry, including the development of new products by others that may provide alternative or better therapies; failure to secure and enforce our intellectual property rights; risks associated with use of biological and hazardous materials; acceptance of our potential products by healthcare providers and patients; our exposure to product liability claims; and our dependence on key personnel.

This release should be read in conjunction with the consolidated financial statements and notes thereto included in our most recent reports on Form 10-K and Form 10-Q.  Copies are available through the SEC’s Electronic Data Gathering Analysis and Retrieval system (EDGAR) at www.sec.gov.  Lipid Sciences assumes no obligation to update the forward-looking statements included in this document.

Press releases for Lipid Sciences, Inc. are available on our website: www.lipidsciences.com.  If you would like to receive our press releases via email, please contact: info@lipidsciences.com.



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