Exhibit 31.1

CERTIFICATION OF CHIEF EXECUTIVE OFFICER

Rule 13a-14a/15d-14a Certfication

I, Jeffrey F. O’Donnell, certify that:

(1) I have reviewed this annual report on Form 10-K of PhotoMedex, Inc.;

(2) Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;

Dated: May 8, 2008	By:	/s/ Jeffrey F. O'Donnell
	Jeffrey F. O'Donnell
	Chief Executive Officer