FILED UNDER RULE 424(b)(3) OF REGULATION C
                                                      SEC FILE NUMBER: 333-53157
PROSPECTUS SUPPLEMENT
(TO PROSPECTUS DATED JULY 2, 1998)



                                CENTOCOR, INC.

              $460,000,000 PRINCIPAL AMOUNT OF 4 3/4% CONVERTIBLE
                       SUBORDINATED DEBENTURES DUE 2005
                 (INTEREST PAYABLE AUGUST 15 AND FEBRUARY 15)
                     -------------------------------------
                            9,338,015 COMMON SHARES
                          ($.01 PAR VALUE PER SHARE)
                           ------------------------

     The information in this Prospectus Supplement concerning the Selling
Securityholders supplements the statement set forth under the caption "Selling
Securityholders" in the Prospectus, as supplemented on July 9, 16 and 29, 1998,
August 4, 11, 18 and 24, 1998, September 1, 3, 15, 21 and 24, 1998, October 1,
13, 14 and 20, 1998 and November 9 and 12, 1998. Capitalized terms used and not
defined herein shall have the meanings given to them in the Prospectus.

                            SELLING SECURITYHOLDERS

     The information set forth under the caption "Selling Securityholders" in
the Prospectus, as supplemented on July 9, 16 and 29, 1998, August 4, 11, 18 and
24, 1998, September 1, 3, 15, 21 and 24, 1998, October 1, 13, 14 and 20, 1998
and November 9 and 12, 1998, is supplemented to add the following:


 
                                                                       NUMBER OF
                                                                       CONVERSION
NAME OF SELLING       AMOUNT OF DEBENTURES        PERCENT OF          SHARES THAT
SECURITYHOLDER(1)      BENEFICIALLY OWNED   OUTSTANDING DEBENTURES   MAY BE SOLD(2)
- --------------------  --------------------  -----------------------  --------------
                                                            
 
Teachers Insurance
and Annuity
Association of
America                    $3,000,000                 .652%              60,900
- ---------------


(1)  The information set forth herein is as of November 16, 1998 and will be
     updated as required.

(2)  Assumes conversion of the full amount of Debentures held by such holder at
     the initial conversion price of $49.261 per share of Common Stock.  Under
     the terms of the Indenture, fractional shares will not be issued upon
     conversion of the Debentures; cash will be paid in lieu of any fractional
     shares.

The date of this Prospectus Supplement is November 16, 1998.