FILED UNDER RULE 424(b)(3) OF REGULATION C
                                                      SEC FILE NUMBER: 333-53157

PROSPECTUS SUPPLEMENT
(TO PROSPECTUS DATED JULY 2, 1998)


                                 CENTOCOR, INC.

              $460,000,000 PRINCIPAL AMOUNT OF 4 3/4% CONVERTIBLE
                        SUBORDINATED DEBENTURES DUE 2005
                  (INTEREST PAYABLE AUGUST 15 AND FEBRUARY 15)
                     -------------------------------------
                            9,338,015 COMMON SHARES
                           ($.01 PAR VALUE PER SHARE)
                            ------------------------

     The information in this Prospectus Supplement concerning the Selling
Securityholders supplements the statement set forth under the caption "Selling
Securityholders" in the Prospectus, as supplemented on July 9, 1998, July 16,
1998, July 29, 1998, August 4, 1998, August 11, 1998, August 18, 1998, August
24, 1998, September 1, 1998, September 3, 1998 and September 15, 1998.
Capitalized terms used and not defined herein shall have the meanings given to
them in the Prospectus.

                            SELLING SECURITYHOLDERS

     The information set forth under the caption "Selling Securityholders" in
the Prospectus, as supplemented on July 9, 1998, July 16, 1998, July 29, 1998,
August 4, 1998, August 11, 1998, August 18, 1998, August 24, 1998, September 1,
1998, September 3, 1998, and September 15, 1998, is supplemented to add the
following:

 
 
                                                                         NUMBER OF
                                                                         CONVERSION
NAME OF SELLING      AMOUNT OF DEBENTURES           PERCENT OF           SHARES THAT
SECURITYHOLDER(1)     BENEFICIALLY OWNED      OUTSTANDING DEBENTURES    MAY BE SOLD(2)
- -----------------    --------------------     ----------------------    --------------
                                                                 
PaineWebber
  Incorporated            $500,000                     .11%                 10,150
 ____________________________
 
(1)  The information set forth herein is as of September 21, 1998 and will be
     updated as required.

(2)  Assumes conversion of the full amount of Debentures held by such holder at
     the initial conversion price of $49.261 per share of Common Stock.  Under
     the terms of the Indenture, fractional shares will not be issued upon
     conversion of the Debentures; cash will be paid in lieu of any fractional
     shares.

The date of this Prospectus Supplement is September 21, 1998.