FILED UNDER RULE 424(b)(3) OF REGULATION C
                                                      SEC FILE NUMBER: 333-53157

PROSPECTUS SUPPLEMENT
(TO PROSPECTUS DATED JULY 2, 1998)

                                CENTOCOR, INC.

              $460,000,000 PRINCIPAL AMOUNT OF 4 3/4% CONVERTIBLE
                       SUBORDINATED DEBENTURES DUE 2005
                 (INTEREST PAYABLE AUGUST 15 AND FEBRUARY 15)
                         ----------------------------
                            9,338,015 COMMON SHARES
                          ($.01 PAR VALUE PER SHARE)
                        ------------------------------

     The information in this Prospectus Supplement concerning the Selling 
Securityholders supplements the statement set forth under the caption "Selling
Securityholders" in the Prospectus, as supplemented on July 9, 1998 and July
16, 1998. Capitalized terms used and not defined herein shall have the meanings
given to them in the Prospectus.

                            SELLING SECURITYHOLDERS

     The information set forth under the caption "Selling Securityholders" in 
the Prospectus, as supplemented on July 9, 1998 and July 16, 1998, is 
supplemented to add the following:



                                                                                  NUMBER OF
                                                                                 CONVERSION
NAME OF SELLING         AMOUNT OF DEBENTURES             PERCENT OF              SHARES THAT
SECURITYHOLDER(1)        BENEFICIALLY OWNED        OUTSTANDING DEBENTURES       MAY BE SOLD(2)
- -----------------       --------------------       ----------------------       --------------
                                                                       
NationsBanc
Montgomery
Securities LLC              $10,770,000                    2.34                     218,631

- ------------------------
(1) The information set forth herein is as of July 29, 1998 and will be updated 
    as required.
(2) Assumes conversion of the full amount of Debentures held by such holder at 
    the initial conversion price of $49.261 per share of Common Stock. Under the
    terms of the Indenture, fractional shares will not be issued upon conversion
    of the Debentures; cash will be paid in lieu of any fractional shares.

The date of this Prospectus Supplement is July 29, 1998.