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Income Taxes - Schedule of Effective Income Tax Rate Reconciliation (Details)
12 Months Ended
Dec. 31, 2020
Dec. 31, 2019
Dec. 31, 2018
Income Tax Disclosure [Abstract]      
State taxes, net of federal benefit 2.80% (4.50%) 4.40%
Nondeductible expenses (0.20%) (0.30%) (0.60%)
Tax credits (including R&D) 4.50% 4.00% 4.60%
Expired tax credit 0.00% (1.30%) (3.90%)
Deferred tax adjustment 0.60% (4.80%) 0.00%
Stock based compensation 0.40% 1.90% 0.80%
Redemption of notes (2.90%) 0.00% 0.00%
Valuation allowance (19.60%) 3.20% (167.00%)
Contingent purchase revaluation 0.00% 0.00% (1.00%)
Other 1.00% (0.30%) (0.10%)
Total 7.60% 18.90% (141.80%)