-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 CBo4jpb5SCjPBjF24U/0Y8dqFR4exW/+IJh1GdKCt7Sid5WtaMPM2peHB8KpAj11
 EUP0EqXWMpeNUZM5u6SyPQ==

<SEC-DOCUMENT>0000950162-05-000083.txt : 20050119
<SEC-HEADER>0000950162-05-000083.hdr.sgml : 20050119
<ACCEPTANCE-DATETIME>20050119185513
ACCESSION NUMBER:		0000950162-05-000083
CONFORMED SUBMISSION TYPE:	4/A
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20050107
FILED AS OF DATE:		20050119
DATE AS OF CHANGE:		20050119

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			SIGMA TAU FINANZIARIA SPA
		CENTRAL INDEX KEY:			0001092601
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		4/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-15070
		FILM NUMBER:		05537356

	MAIL ADDRESS:	
		STREET 1:		VIA SUDAFRICA 20
		STREET 2:		00144
		CITY:			ROME ITALY

	FORMER NAME:	
		FORMER CONFORMED NAME:	SIGMA TAU FINANZIARIA
		DATE OF NAME CHANGE:	19990805

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			REGENERX BIOPHARMACEUTICALS INC
		CENTRAL INDEX KEY:			0000707511
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				521253406
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		3 BETHESDA METRO CENTER
		STREET 2:		SUITE 700
		CITY:			BETHESDA
		STATE:			MD
		ZIP:			20814
		BUSINESS PHONE:		3019611992

	MAIL ADDRESS:	
		STREET 1:		3 BETHESDA METRO CENTER
		STREET 2:		SUITE 700
		CITY:			BETHESDA
		STATE:			MD
		ZIP:			20814

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ALPHA 1 BIOMEDICALS INC
		DATE OF NAME CHANGE:	19950719
</SEC-HEADER>
<DOCUMENT>
<TYPE>4/A
<SEQUENCE>1
<FILENAME>sigmatauform4-011405_ex.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>4/A</documentType>

    <periodOfReport>2005-01-07</periodOfReport>

    <dateOfOriginalSubmission>2005-01-05</dateOfOriginalSubmission>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0000707511</issuerCik>
        <issuerName>REGENERX BIOPHARMACEUTICALS INC</issuerName>
        <issuerTradingSymbol>RGRX.OB</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001092601</rptOwnerCik>
            <rptOwnerName>SIGMA TAU FINANZIARIA SPA</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>SIGMA-TAU FINANZIARIA SPA</rptOwnerStreet1>
            <rptOwnerStreet2>VIA SUDAFRICA, 20</rptOwnerStreet2>
            <rptOwnerCity>ROME</rptOwnerCity>
            <rptOwnerState>L6</rptOwnerState>
            <rptOwnerZipCode>00144</rptOwnerZipCode>
            <rptOwnerStateDescription>ITALY</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2005-01-07</value>
                <footnoteId id="F1"/>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>P</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>0</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>9875152</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2005-01-07</value>
                <footnoteId id="F5"/>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>P</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
                <footnoteId id="F5"/>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>0</value>
                    <footnoteId id="F5"/>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0</value>
                    <footnoteId id="F5"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                    <footnoteId id="F5"/>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>9875152</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                    <footnoteId id="F2"/>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>I</value>
                    <footnoteId id="F2"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <derivativeTable>
        <derivativeTransaction>
            <securityTitle>
                <value>Warrants</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>4.06</value>
            </conversionOrExercisePrice>
            <transactionDate>
                <value>2005-01-07</value>
                <footnoteId id="F1"/>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>J</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
                <footnoteId id="F3"/>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>246154</value>
                </transactionShares>
                <transactionPricePerShare>
                    <footnoteId id="F5"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <exerciseDate>
                <footnoteId id="F4"/>
            </exerciseDate>
            <expirationDate>
                <value>2008-01-07</value>
                <footnoteId id="F1"/>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>246154</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>246154</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeTransaction>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">This amendment is being filed to amend the transaction date from January 3, 2005 to January 7, 2005 and the expiration date
for the warrants from January 3, 2008 to January 7, 2008.</footnote>
        <footnote id="F2">The Shares are owned directly by Defiante Farmaceutica L.D.A., which is 58% directly owned by Sigma Tau Finanzaria S.p.A.
(&quot;Sigma Tau&quot;) and 42% directly owned by Sigma Tau's wholly-owned subsidiary, Sigma Tau International S.A.</footnote>
        <footnote id="F3">The Warrants were issued by the Issuer to the Reporting Person in consideration of the Reporting Person's purchase of Common
Stock.</footnote>
        <footnote id="F4">Immediately.</footnote>
        <footnote id="F5">N/A.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Antonio Nicolai, Antonio Nicolai, Director</signatureName>
        <signatureDate>2005-01-19</signatureDate>
    </ownerSignature>
</ownershipDocument>

</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----