Filed by: Old National Bancorp

(Commission File No.: 001-15817)

Pursuant to Rule 425 under the Securities Act of 1933, as amended

and deemed filed pursuant to Rule 14a-12

of the Securities Exchange Act of 1934, as amended

Subject Company: First Midwest Bancorp, Inc.

(Commission File No.: 001-39320)

July 20, 2021

The following excerpts relating to the pending business combination between First Midwest Bancorp, Inc. (“First Midwest”) and Old National Bancorp (“Old National”) are from the presentation materials in connection with Old National’s announcement of its financial results for the quarter ended June 30, 2021.