-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
 MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen
 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 MvyQ6ZeGEdNlEcUHmZXoo7lM5kKpTxQLRfZc9Adj1jmVcln06zQdvKkx0pTO/dED
 4GUh3ktSskDgmnuVMzulFQ==

<SEC-DOCUMENT>0000702325-08-000122.txt : 20080821
<SEC-HEADER>0000702325-08-000122.hdr.sgml : 20080821
<ACCEPTANCE-DATETIME>20080821185831
ACCESSION NUMBER:		0000702325-08-000122
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20080820
FILED AS OF DATE:		20080821
DATE AS OF CHANGE:		20080821

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			FIRST MIDWEST BANCORP INC
		CENTRAL INDEX KEY:			0000702325
		STANDARD INDUSTRIAL CLASSIFICATION:	NATIONAL COMMERCIAL BANKS [6021]
		IRS NUMBER:				363161078
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		ONE PIERCE PLACE
		STREET 2:		SUITE 1500
		CITY:			ITASCA
		STATE:			IL
		ZIP:			60143
		BUSINESS PHONE:		6308757450

	MAIL ADDRESS:	
		STREET 1:		ONE PIERCE PLACE
		STREET 2:		SUITE 1500
		CITY:			ITASCA
		STATE:			IL
		ZIP:			60143

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Boigegrain Barbara A
		CENTRAL INDEX KEY:			0001443274

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-10967
		FILM NUMBER:		081033100

	BUSINESS ADDRESS:	
		BUSINESS PHONE:		630 875 7345

	MAIL ADDRESS:	
		STREET 1:		ONE PIERCE PLACE
		STREET 2:		SUITE 1500
		CITY:			ITASCA
		STATE:			IL
		ZIP:			60143
</SEC-HEADER>
<DOCUMENT>
<TYPE>3
<SEQUENCE>1
<FILENAME>boi724.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0203</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2008-08-20</periodOfReport>

    <noSecuritiesOwned>1</noSecuritiesOwned>

    <issuer>
        <issuerCik>0000702325</issuerCik>
        <issuerName>FIRST MIDWEST BANCORP INC</issuerName>
        <issuerTradingSymbol>FMBI</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001443274</rptOwnerCik>
            <rptOwnerName>Boigegrain Barbara A</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>ONE PIERCE PLACE, SUITE 1500</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>ITASCA</rptOwnerCity>
            <rptOwnerState>IL</rptOwnerState>
            <rptOwnerZipCode>60143</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <footnotes></footnotes>

    <remarks>The Reporting Person is the GS and CEO of the Gen. Bd of Pen. &amp; Health Ben. of The UMC (?GB?). She is not a shareholder of the GB or have investment power over any FMBI stock owned by GB. Thus, this rpt. does not reflect any GB holdings in FMBI.</remarks>

    <ownerSignature>
        <signatureName>/s/ Boigegrain, Barbara A.</signatureName>
        <signatureDate>2008-08-20</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----