February 22, 2019

Steven Babinski
Assistant General Counsel
First Midwest Bancorp, Inc.
8750 West Bryn Mawr Avenue
Suite 1300
Chicago, Illinois 60631

       Re: First Midwest Bancorp, Inc.
           Registration Statement on Form S-4
           Filed February 14, 2019
           File No. 333-229674

Dear Mr. Babinski:

       This is to advise you that we have not reviewed and will not review your
registration
statement.

        Please refer to Rules 460 and 461 regarding requests for acceleration.
We remind you
that the company and its management are responsible for the accuracy and
adequacy of their
disclosures, notwithstanding any review, comments, action or absence of action
by the staff.

       Please contact Erin Purnell at 202-551-3454 with any questions.



                                                            Sincerely,

                                                            Division of
Corporation Finance
                                                            Office of Financial
Services