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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 Foe/ENyaqF6BUZ9rO1EopExzlqGpa1Udns+20m8alX0lHMy+WuuD02k3tSKpWOot
 xLUs2OH9riJ1dmcW+w2r0A==

<SEC-DOCUMENT>0001225208-08-005138.txt : 20080318
<SEC-HEADER>0001225208-08-005138.hdr.sgml : 20080318
<ACCEPTANCE-DATETIME>20080318162050
ACCESSION NUMBER:		0001225208-08-005138
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20080315
FILED AS OF DATE:		20080318
DATE AS OF CHANGE:		20080318

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			MINE SAFETY APPLIANCES CO
		CENTRAL INDEX KEY:			0000066570
		STANDARD INDUSTRIAL CLASSIFICATION:	ORTHOPEDIC, PROSTHETIC & SURGICAL APPLIANCES & SUPPLIES [3842]
		IRS NUMBER:				250668780
		STATE OF INCORPORATION:			PA
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		121 GAMMA DR
		STREET 2:		OHARA TOWNSHIP
		CITY:			PITTSBURGH
		STATE:			PA
		ZIP:			15238
		BUSINESS PHONE:		4129673000

	MAIL ADDRESS:	
		STREET 1:		P O BOX 426
		CITY:			PITTSBURGH
		STATE:			PA
		ZIP:			15230

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			BIGLER JOSEPH A
		CENTRAL INDEX KEY:			0001187321

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-15579
		FILM NUMBER:		08696620

	BUSINESS ADDRESS:	
		STREET 1:		P O BOX 426
		CITY:			PITTSBURGH
		STATE:			PA
		ZIP:			15230-0426
		BUSINESS PHONE:		4129673000
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>doc4.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2008-03-15</periodOfReport>

    <issuer>
        <issuerCik>0000066570</issuerCik>
        <issuerName>MINE SAFETY APPLIANCES CO</issuerName>
        <issuerTradingSymbol>MSA</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001187321</rptOwnerCik>
            <rptOwnerName>BIGLER JOSEPH A</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>121 GAMMA DRIVE</rptOwnerStreet1>
            <rptOwnerStreet2>RIDC INDUSTRIAL PARK</rptOwnerStreet2>
            <rptOwnerCity>PITTSBURGH</rptOwnerCity>
            <rptOwnerState>PA</rptOwnerState>
            <rptOwnerZipCode>15238</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isOfficer>1</isOfficer>
            <officerTitle>Vice President</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock, no par value</value>
            </securityTitle>
            <transactionDate>
                <value>2008-03-15</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>S</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>279</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>41.58</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>53638</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <derivativeTable></derivativeTable>

    <footnotes></footnotes>

    <remarks></remarks>

    <ownerSignature>
        <signatureName>Douglas K. McClaine, Attorney in Fact</signatureName>
        <signatureDate>2008-03-18</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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