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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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 dp33586Zx6lxx4OYcaU/8A==

<SEC-DOCUMENT>0001225208-10-025379.txt : 20101122
<SEC-HEADER>0001225208-10-025379.hdr.sgml : 20101122
<ACCEPTANCE-DATETIME>20101122162630
ACCESSION NUMBER:		0001225208-10-025379
CONFORMED SUBMISSION TYPE:	4/A
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20091103
FILED AS OF DATE:		20101122
DATE AS OF CHANGE:		20101122

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			MERCK SHARP & DOHME CORP.
		CENTRAL INDEX KEY:			0000064978
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				221109110
		STATE OF INCORPORATION:			NJ
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		ONE MERCK DR
		STREET 2:		P O BOX 100
		CITY:			WHITEHOUSE STATION
		STATE:			NJ
		ZIP:			08889-0100
		BUSINESS PHONE:		9084231688

	MAIL ADDRESS:	
		STREET 1:		ONE MERCK DR
		STREET 2:		PO BOX 100 WS3AB-05
		CITY:			WHITEHOUSE STATION
		STATE:			NJ
		ZIP:			08889-0100

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	MERCK & CO INC
		DATE OF NAME CHANGE:	19920703

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			REPRESAS CARLOS E
		CENTRAL INDEX KEY:			0001216083

	FILING VALUES:
		FORM TYPE:		4/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-03305
		FILM NUMBER:		101209034

	MAIL ADDRESS:	
		STREET 1:		C/O NESTLE S.A.,
		STREET 2:		55 AVENUE NESTLE
		CITY:			1800 VEVEY
		STATE:			V8
		ZIP:			00000
</SEC-HEADER>
<DOCUMENT>
<TYPE>4/A
<SEQUENCE>1
<FILENAME>doc4a.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0303</schemaVersion>

    <documentType>4/A</documentType>

    <periodOfReport>2009-11-03</periodOfReport>

    <dateOfOriginalSubmission>2009-11-04</dateOfOriginalSubmission>

    <notSubjectToSection16>1</notSubjectToSection16>

    <issuer>
        <issuerCik>0000064978</issuerCik>
        <issuerName>MERCK SHARP &amp; DOHME CORP.</issuerName>
        <issuerTradingSymbol>MRK</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001216083</rptOwnerCik>
            <rptOwnerName>REPRESAS CARLOS E</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>GRUPO NESTLE MEXICO</rptOwnerStreet1>
            <rptOwnerStreet2>AV. EJERCITO NACIONAL NO. 453</rptOwnerStreet2>
            <rptOwnerCity>11520 MEXICO, D.F.</rptOwnerCity>
            <rptOwnerState>O5</rptOwnerState>
            <rptOwnerZipCode></rptOwnerZipCode>
            <rptOwnerStateDescription>MEXICO</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2009-11-03</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>J</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>1000.0000</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0.0000</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>0.0000</value>
                    <footnoteId id="F1"/>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>By Trust</value>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <derivativeTable></derivativeTable>

    <footnotes>
        <footnote id="F1">This amended Form 4 is being filed to report a family trust inadvertently omitted on the original filing.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>Katie Fedosz as Attorney-in-Fact for Carlos E. Represas</signatureName>
        <signatureDate>2010-11-22</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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