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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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<SEC-DOCUMENT>0001225208-09-021692.txt : 20091104
<SEC-HEADER>0001225208-09-021692.hdr.sgml : 20091104
<ACCEPTANCE-DATETIME>20091104210325
ACCESSION NUMBER:		0001225208-09-021692
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20091103
FILED AS OF DATE:		20091104
DATE AS OF CHANGE:		20091104

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			JACOBSON HARRY R
		CENTRAL INDEX KEY:			0001255835

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-03305
		FILM NUMBER:		091159242

	MAIL ADDRESS:	
		STREET 1:		836 GLEN LEVEN DRIVE
		CITY:			NASHVILLE
		STATE:			TN
		ZIP:			37204

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			MERCK SHARP & DOHME CORP.
		CENTRAL INDEX KEY:			0000064978
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				221109110
		STATE OF INCORPORATION:			NJ
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		ONE MERCK DR
		STREET 2:		P O BOX 100
		CITY:			WHITEHOUSE STATION
		STATE:			NJ
		ZIP:			08889-0100
		BUSINESS PHONE:		9084231688

	MAIL ADDRESS:	
		STREET 1:		ONE MERCK DR
		STREET 2:		PO BOX 100 WS3AB-05
		CITY:			WHITEHOUSE STATION
		STATE:			NJ
		ZIP:			08889-0100

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	MERCK & CO INC
		DATE OF NAME CHANGE:	19920703
</SEC-HEADER>
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<TYPE>4
<SEQUENCE>1
<FILENAME>doc4.xml
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<ownershipDocument>

    <schemaVersion>X0303</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2009-11-03</periodOfReport>

    <notSubjectToSection16>1</notSubjectToSection16>

    <issuer>
        <issuerCik>0000064978</issuerCik>
        <issuerName>MERCK SHARP &amp; DOHME CORP.</issuerName>
        <issuerTradingSymbol>MRK</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001255835</rptOwnerCik>
            <rptOwnerName>JACOBSON HARRY R</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>D-3300 MEDICAL CENTER NORTH</rptOwnerStreet1>
            <rptOwnerStreet2>GARLAND AVENUE</rptOwnerStreet2>
            <rptOwnerCity>NASHVILLE</rptOwnerCity>
            <rptOwnerState>TN</rptOwnerState>
            <rptOwnerZipCode>37232</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
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            <securityTitle>
                <value>Common Stock</value>
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            <transactionDate>
                <value>2009-11-03</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>D</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
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                </transactionShares>
                <transactionPricePerShare>
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        </derivativeTransaction>
        <derivativeTransaction>
            <securityTitle>
                <value>Stock Option (right to buy)</value>
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            <conversionOrExercisePrice>
                <value>38.04</value>
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                <value>2009-11-03</value>
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                <transactionAcquiredDisposedCode>
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            <exerciseDate>
                <value>2009-04-30</value>
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            <expirationDate>
                <value>2018-04-29</value>
            </expirationDate>
            <underlyingSecurity>
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        <derivativeTransaction>
            <securityTitle>
                <value>Stock Option (right to buy)</value>
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            <conversionOrExercisePrice>
                <value>24.3</value>
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            <transactionDate>
                <value>2009-11-03</value>
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            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>D</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
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            <transactionAmounts>
                <transactionShares>
                    <value>5000</value>
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                <transactionPricePerShare>
                    <value>0</value>
                    <footnoteId id="F3"/>
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                <transactionAcquiredDisposedCode>
                    <value>D</value>
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            </transactionAmounts>
            <exerciseDate>
                <value>2010-05-01</value>
                <footnoteId id="F3"/>
            </exerciseDate>
            <expirationDate>
                <value>2019-04-30</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>5000</value>
                </underlyingSecurityShares>
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            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>0</value>
                </sharesOwnedFollowingTransaction>
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            <ownershipNature>
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                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeTransaction>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">Disposal of upon the completion of and pursuant to the transactions contemplated by the Agreement and Plan of Merger with, inter alia, Schering-Plough Corporation (the &quot;Transactions&quot;) under which Schering-Plough Corporation (renamed as Merck &amp; Co., Inc.) survives (the &quot;Surviving Corporation&quot;) and becomes the sole shareholder of Merck &amp; Co., Inc. (renamed Merck Sharp &amp; Dohme Corp.) (&quot;Old Merck&quot;).  Such shares of Old Merck common stock are being exchanged pursuant to the Transactions for an equivalent amount of whole and fractional shares of Surviving Corporation common stock.  On the effective date of the Transactions, the closing price of Old Merck common stock was $30.67 per share and the closing price of Schering-Plough Corporation common stock was $28.15 per share.</footnote>
        <footnote id="F2">Each share of phantom stock is the economic equivalent of one share of Old Merck common stock, and was granted under the Plan for Deferred Payment of Directors Compensation.  The Plan for Deferred Payment of Directors Compensation will be continued after the Transactions and each share of phantom stock will have the economic equivalent of one share of Surviving Corporation Common Stock.</footnote>
        <footnote id="F3">This option to purchase shares of Old Merck common stock, which vesting in three equal annual installments beginning one year from date of grant, was assumed by the Surviving Corporation in the Transactions and continued on the same terms and conditions as an option to purchase an equivalent number of shares of Surviving Corporation Common Stock at the same exercise price as applied prior to the Transactions.</footnote>
    </footnotes>

    <remarks></remarks>

    <ownerSignature>
        <signatureName>Debra A. Bollwage as Attorney-in-Fact for Harry R. Jacobson</signatureName>
        <signatureDate>2009-11-04</signatureDate>
    </ownerSignature>
</ownershipDocument>
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</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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