-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
 MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen
 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 Ndg+7AvheEqvSsQrV58sQhFt/PKFADy7LPVdQ2iHzX0lbsyc7UjfGOp9LL+2lMj7
 21rv5tEU4EfjccBLIHOYtg==

<SEC-DOCUMENT>0000895345-06-000891.txt : 20061115
<SEC-HEADER>0000895345-06-000891.hdr.sgml : 20061115
<ACCEPTANCE-DATETIME>20061115154757
ACCESSION NUMBER:		0000895345-06-000891
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20061109
FILED AS OF DATE:		20061115
DATE AS OF CHANGE:		20061115

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			FOXHOLLOW TECHNOLOGIES, INC.
		CENTRAL INDEX KEY:			0001217688
		STANDARD INDUSTRIAL CLASSIFICATION:	SURGICAL & MEDICAL INSTRUMENTS & APPARATUS [3841]
		IRS NUMBER:				943252085
		STATE OF INCORPORATION:			DE

	BUSINESS ADDRESS:	
		STREET 1:		740 BAY ROAD
		CITY:			REDWOOD CITY
		STATE:			CA
		ZIP:			94063-2469
		BUSINESS PHONE:		650-421-8400

	MAIL ADDRESS:	
		STREET 1:		740 BAY ROAD
		CITY:			REDWOOD CITY
		STATE:			CA
		ZIP:			94063-2469

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	FOX HOLLOW TECHNOLOGIES INC
		DATE OF NAME CHANGE:	20030206

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			MERCK & CO INC
		CENTRAL INDEX KEY:			0000064978
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		STATE OF INCORPORATION:			NJ
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-50998
		FILM NUMBER:		061219912

	BUSINESS ADDRESS:	
		STREET 1:		ONE MERCK DR
		STREET 2:		P O BOX 100
		CITY:			WHITEHOUSE STATION
		STATE:			NJ
		ZIP:			08889-0100
		BUSINESS PHONE:		9084231688

	MAIL ADDRESS:	
		STREET 1:		ONE MERCK DR
		STREET 2:		PO BOX 100 WS3AB-05
		CITY:			WHITEHOUSE STATION
		STATE:			NJ
		ZIP:			08889-0100
</SEC-HEADER>
<DOCUMENT>
<TYPE>3
<SEQUENCE>1
<FILENAME>ds3-foxhollow_merckex.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2006-11-09</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001217688</issuerCik>
        <issuerName>FOXHOLLOW TECHNOLOGIES, INC.</issuerName>
        <issuerTradingSymbol>FOXH</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0000064978</rptOwnerCik>
            <rptOwnerName>MERCK &amp; CO INC</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>ONE MERCK DRIVE</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>WHITEHOUSE STATION</rptOwnerCity>
            <rptOwnerState>NJ</rptOwnerState>
            <rptOwnerZipCode>08889-0100</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>3206318</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <ownerSignature>
        <signatureName>/s/ Mark E. McDonough, Assistant Treasurer</signatureName>
        <signatureDate>2006-11-09</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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