QuickLinks -- Click here to rapidly navigate through this document

AGREEMENT TO MAKE A JOINT FILING

        The undersigned hereby agree to file a joint Schedule 13G with respect to the interests of the undersigned in Advanced Tissue Sciences, Inc. and that the Amendment to Schedule 13G to which this Agreement is attached has been filed on behalf of each of the undersigned.

Date: February 6, 2002
	MEDTRONIC, INC.
	By:	/s/  CAROL E. MALKINSON Carol E. Malkinson Senior Legal Counsel and Assistant Secretary
	MEDTRONIC INTERNATIONAL, LTD.
	By:	/s/  CAROL E. MALKINSON Carol E. Malkinson Assistant Secretary

Page 7 of 7 Pages

QuickLinks

AGREEMENT TO MAKE A JOINT FILING