Revenue (Summary of Revenue Recognized) (Details) - USD ($) $ in Millions	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Disaggregation of Revenue [Line Items]
Revenues	$ 28,318.4	$ 24,539.8	$ 22,319.5
Net product revenue
Disaggregation of Revenue [Line Items]
Revenues	25,957.9	22,694.8	20,377.3
Collaboration and other revenue
Disaggregation of Revenue [Line Items]
Revenues	2,360.5	1,845.0	1,942.2
Collaboration and other revenue associated with prior period transfers of intellectual property
Disaggregation of Revenue [Line Items]
Revenues	$ 175.0	$ 135.6	$ 301.5