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Revenue (Summary of Revenue Recognized) (Details) - USD ($)
$ in Millions
3 Months Ended 6 Months Ended
Jun. 30, 2019
Jun. 30, 2018
Jun. 30, 2019
Jun. 30, 2018
Disaggregation of Revenue [Line Items]        
Revenue $ 5,636.7 $ 5,585.0 $ 10,728.9 $ 10,548.8
Net product revenue        
Disaggregation of Revenue [Line Items]        
Revenue 5,168.7 5,129.4 9,861.0 9,735.3
Collaboration and other revenue        
Disaggregation of Revenue [Line Items]        
Revenue 468.0 455.6 867.9 813.5
Royalty        
Disaggregation of Revenue [Line Items]        
Revenue $ 59.6 $ 133.6 $ 95.1 $ 183.7