UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                   FORM 24F-2

                        Annual Notice of Securities Sold
                             Pursuant to Rule 24f-2

Read instructions at end of Form before preparing Form.

1.   Name and address of issuer:

     RiverSource Large Cap Series, Inc.
     200 Ameriprise Financial
     Minneapolis, MN 55474

2.   The name of each series or class of securities for which this Form is filed
     (if the Form is being filed for all series and classes of securities of the
     issuer, check the box but do not list series of classes):

     [X]

3.   Investment Company Act File Number:

     811-2111

     Securities Act File Number:

     2-38355

4(a). Last day of fiscal year for which this Form is filed:

     July 31, 2010

4(b). Check box if this Form is being file late (i.e., more than 90 calendar
     days after the end of the issuer's fiscal year).
     (See Instruction A.2)

     [ ]

     Note: If the Form is being filed late, interest must be paid on the
     registration fee due.

4(c). Check box if this is the last time the issuer will be filing this Form:

     [ ]

5.   Calculation of registration fee:

     (i)  Aggregate sale price of securities sold during the fiscal year
          pursuant to section 24(f):

                                                                 $308,895,602.34



     (ii) Aggregate price of securities redeemed or repurchased during the
          fiscal year:

                                                               $1,266,725,327.09

     (iii) Aggregate price of securities redeemed or repurchased during any
          prior fiscal year ending no earlier than October 11, 1995 that were
          not previously used to reduce registration fees payable to the
          Commission:

                                                                 $312,303,465.26

     (iv) Total available redemption credits [add Items 5(ii) and 5(iii)]:

                                                               $1,579,028,792.35

     (v)  Net sales - if Item 5(i) is greater than Item 5(iv) [subtract Item
          5(iv) from Item 5(i)]:

                                                                           $0.00

     (vi) Redemption credits available for use in future years if item 5(i) is
          less than Item 5(iv) [subtract Item 5(iv) from Item 5(i)]:

                                                             - $1,270,133,190.01

     (vii) Multiplier for determining registration fee (see Instruction C.9):

                                                                       0.0000713

     (viii)Registration fee due [multiply Item 5(v) by Item 5(vii)] (enter "0"
          if no fee is due):

                                                                           $0.00

6.   Prepaid Shares

     If the response to Item 5(i) was determined by deducting an amount of
     securities that were registered under the Securities Act of 1933 pursuant
     to rule 24e-2 as in effect before October 11, 1997, then report the amount
     of securites (number of shares or other units) deducted here:__. If there
     is a number of shares or other units that were registered pursuant to the
     rule 24e-2 remaining unsold at the end of the fiscal year for which this
     form is filed that are available for use by the issuer in future fiscal
     years, then state that number here: __.

7.   Interest Due - if this Form is being filed more than 90 days after the end
     of the issuer's fiscal year (see Instruction D):

                                                                           $0.00

8.   Total of the amount of the registration fee due plus any interest due [line
     5(viii) plus line 7]:

                                                                           $0.00

9.   Date the registration fee and any interest payment was sent to the
     Commission's lockbox depository:

     Method of Delivery:

     [ ]  Wire Transfer

     [ ]  Mail or other means



SIGNATURES

This report has been signed below by the following persons on behalf of the
issuer and in the capacities and on the dates indicated.


By (Signature and Title)* /s/ Jeffrey P. Fox
                          ------------------------------------------
                          Jeffrey P. Fox
                          Treasurer and Principal Financial Officer

Date October 21, 2010

*    Please print the name and the title of the signing officer below the
     signature.