Sept. 27, 2010

Securities and Exchange Commission
100 F Street, N.E.
Washington, D.C. 20549

ATTN: Ms. Patsy Mengiste
      Document Control - EDGAR

RE: RiverSource Large Cap Series, Inc.
       Columbia Large Core Quantitative Fund (formerly known as RiverSource
       Disciplined Equity Fund)
    Post-Effective Amendment No. 87
    File No. 2-38355/811-2111
    ACCESSION NUMBER: 0000950123-10-088831

Dear Ms. Mengiste:

Pursuant to Rule 497(j) under the Securities Act of 1933, as amended, please
accept this letter as certification that the prospectuses and Statement of
Additional Information for the above-referenced fund does not differ from that
contained in Registrant's Post-Effective Amendment No. 87 (Amendment). This
Amendment was filed electronically on Sept. 24, 2010.

If you have any questions regarding this filing, please contact either Andrew
Kirn at (612) 678-9052 or me at (212) 850-1703.

Sincerely,


/s/ Christopher O. Petersen
-------------------------------------
Christopher O. Petersen
Vice President and Chief Counsel
Ameriprise Financial, Inc.