Summary of Significant Accounting Policies (Details 4) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Derivative [Line Items]
Product revenues	$ 1,889,065	$ 1,848,399	$ 1,534,033
Foreign currency exchange forward contracts | Maximum
Derivative [Line Items]
Maximum typical term of foreign currency forward exchange contracts (in days)	90 days