Summary of Significant Accounting Policies (Details 4) - USD ($) $ in Thousands	3 Months Ended								12 Months Ended
	Dec. 31, 2021	Sep. 30, 2021	Jun. 30, 2021	Mar. 31, 2021	Dec. 31, 2020	Sep. 30, 2020	Jun. 30, 2020	Mar. 31, 2020	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Derivative [Line Items]
Product revenues	$ 462,100	$ 470,400	$ 468,700	$ 447,300	$ 431,500	$ 416,600	$ 365,600	$ 320,400	$ 1,848,399	$ 1,534,033	$ 1,204,369
Foreign currency exchange forward contracts | Maximum
Derivative [Line Items]
Maximum typical term of foreign currency forward exchange contracts (in days)									90 days